SCRIPTAID

Product Name: SCRIPTAID
CAS No.: 287383-59-9
Chemical Name: SCRIPTAID
Synonyms: CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;Scriptaid, 10 mM in DMSO;Scriptaid, HDAC inhibitor;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
CBNumber: CB5504770
Molecular Formula: C18H18N2O4
Formula Weight: 326.35
MOL File: 287383-59-9.mol

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SCRIPTAID Property

Melting point:: 160-161 °C
Density: 1.338±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 4 mg/ml).
form: Yellow solid.
pka: 9.46±0.20(Predicted)
color: White
biological source: synthetic (organic)
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI: InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChIKey: JTDYUFSDZATMKU-UHFFFAOYSA-N
SMILES: C1(=O)C2=C3C(C=CC=C3C(=O)N1CCCCCC(NO)=O)=CC=C2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7817
Product name: Scriptaid
Purity: ≥95%, solid
Packaging: 1MG
Price: $145.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: S7817
Product name: Scriptaid
Purity: ≥95%, solid
Packaging: 5MG
Price: $520
Updated: 2025/07/31

Sigma-Aldrich

Product number: 565730
Product name: Scriptaid - CAS 287383-59-9 - Calbiochem
Purity: A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.
Packaging: 5MG
Price: $194
Updated: 2022/05/15

TCI Chemical

Product number: C4037
Product name: Scriptaid
Packaging: 100MG
Price: $366
Updated: 2025/07/31

Cayman Chemical

Product number: 10572
Product name: Scriptaid
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

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SCRIPTAID Chemical Properties,Usage,Production

Description

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.

Uses

Scriptaid has been used in post activation of oocytes and embryo culture.

Uses

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

Definition

ChEBI: 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

References

[1] G H SU. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.[J]. Cancer research, 2000, 60 12: 3137-3142.
[2] KELLY HUBER. Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.[J]. The Journal of Biological Chemistry, 2011: 22211-22218. DOI:10.1074/jbc.m110.180224
[3] EUN JU LEE. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells.[J]. International journal of oncology, 2008, 15 1: 767-776. DOI:10.3892/ijo\_00000063
[4] VITOR BRAGA RISSI. Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos.[J]. Reproduction, 2019, 157 2: 123-133. DOI:10.1530/rep-18-0366
[5] SONG HUANG. Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin.[J]. Journal of applied physiology, 2020: 276-285. DOI:10.1152/japplphysiol.00617.2019

SCRIPTAID Preparation Products And Raw materials

Raw materials

Preparation Products

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SCRIPTAID Suppliers

Canada 1 China 112 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 23 Global 141

VDM Biochemicals

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View Lastest Price from SCRIPTAID manufacturers

Career Henan Chemical Co

Product: 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide 287383-59-9
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

287383-59-9, SCRIPTAIDRelated Search:

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6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

GCK 1026; SCRIPTIDE; GCK1026; GCK-1026

CS-1136

GCK 1026

1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-

Scriptide

6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide

Scriptaid, Scriptide

Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

Scriptaid (GCK1026)

Scriptaid, HDAC inhibitor

Scriptaid, 10 mM in DMSO

N-?HYDROXY-?1,?3-?DIOXO-?1H-?BENZ[DE]ISOQUINOLINE-?2(3H)-?HEXANANMIDE

287383-59-9

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