4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester

Product Name: 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester
CAS No.: 158407-04-6
Chemical Name: 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester
Synonyms: tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate;4-BROMOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;CAS:158407-04-6;1-Boc-4-BromomethyL;1-Boc-4-broMoMethylpiperi...;1-BOC-4-BROMOMETHYLPIPERIDINE;N-BOC-4-BROMOMETHYL-PIPERIDINE;1-N-BOC-4-BROMOMETHYLPIPERIDINE;1-Boc-4-(bromoMmethyl)piperidine;4-Bromomethyl-1-(tert-butoxycarbonyl)piperidine
CBNumber: CB6404026
Molecular Formula: C11H20BrNO2
Formula Weight: 278.19
MOL File: 158407-04-6.mol

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4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 318.3±15.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: -1.91±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H20BrNO2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-8H2,1-3H3
InChIKey: YGJXBTRLYHCWGD-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(CBr)CC1

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Safety

Risk Statements: 36/37/38-36
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 796719
Product name: 4-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester
Purity: 95%
Packaging: 1g
Price: $240.8
Updated: 2025/07/31

TCI Chemical

Product number: B6510
Product name: tert-Butyl 4-(Bromomethyl)piperidine-1-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: B6510
Product name: tert-Butyl 4-(Bromomethyl)piperidine-1-carboxylate
Purity: min. 98.0 %
Packaging: 10G
Price: $261
Updated: 2025/07/31

Usbiological

Product number: 265791
Product name: 1-Boc-4-bromomethylpiperidine
Packaging: 500mg
Price: $340
Updated: 2021/12/16

TRC

Product number: T135603
Product name: tert-Butyl4-(Bromomethyl)piperidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process and chemical production process.

Synthesis

4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester. 4-N-Boc-piperidine-methanol (200 mg, 0.93 mmol) was dissolved in diethyl ether (9 mL) and carbon tetrabromide (370 mg, 1.1 mmol) and PPh3 (292 mg, 1.1 mmol) were added at rt. The reaction was allowed to stir for 18 h at rt and filtered over a pad of celite. The filtrate was concentrated and purified by flash chromatography (hexane/EtOAc, 1:0 ?ú 4:1) to give the title compound. Yield 55 mg. 1 (400 MHz, DMSO-d6) |? ppm 4.02-3.98 (m, 2 H), 3.47 (d, 2 H), 2.78-2.65 (m, 2 H), 1.89-1.74 (m, 3 H), 1.45 (s, 9 H), 1.12-0.98 (m, 2 H).

References

[1] Patent: WO2016/75661, 2016, A1. Location in patent: Page/Page column 30
[2] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 120-121
[3] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185
[4] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00266
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 17, p. 2615 - 2620

4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co

Product: 4-BROMOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 158407-04-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

158407-04-6, 4-Bromomethypiperidine-1-carboxylic acid tert-butyl esterRelated Search:

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