Uses
ChemicalBook > CAS DataBase List > 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine

Uses
Product Name
4,6-Dichloropyrimidine
CAS No.
1193-21-1
Chemical Name
4,6-Dichloropyrimidine
Synonyms
NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
CBNumber
CB6473590
Molecular Formula
C4H2Cl2N2
Formula Weight
148.98
MOL File
1193-21-1.mol
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4,6-Dichloropyrimidine Property

Melting point:
65-67 °C (lit.)
Boiling point:
176 °C (lit.)
Density 
1.6445 (rough estimate)
vapor pressure 
30-390Pa at 20-50℃
refractive index 
1.6300 (estimate)
Flash point:
176°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
form 
Crystals
pka
-4.20±0.17(Predicted)
color 
Yellow-green
BRN 
111195
InChIKey
XJPZKYIHCLDXST-UHFFFAOYSA-N
LogP
1.45 at 25℃ and pH7.2
Surface tension
65.72mN/m at 1g/L and 20℃
CAS DataBase Reference
1193-21-1(CAS DataBase Reference)
NIST Chemistry Reference
Pyrimidine, 4,6-dichloro-(1193-21-1)
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Safety

Hazard Codes 
C
Risk Statements 
34-20/21/22-36/37
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
F 
19
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
145378
Product name
4,6-Dichloropyrimidine
Purity
97%
Packaging
10g
Price
$91.3
Updated
2024/03/01
Sigma-Aldrich
Product number
145378
Product name
4,6-Dichloropyrimidine
Purity
97%
Packaging
50g
Price
$126.8
Updated
2024/03/01
TCI Chemical
Product number
D2488
Product name
4,6-Dichloropyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
D2488
Product name
4,6-Dichloropyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$44
Updated
2024/03/01
Alfa Aesar
Product number
L13212
Product name
4,6-Dichloropyrimidine, 98%
Packaging
25g
Price
$133.65
Updated
2024/03/01
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4,6-Dichloropyrimidine Chemical Properties,Usage,Production

Uses

4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.

Chemical Properties

Yellow Solid

Uses

4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.

General Description

Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.

Synthesis

The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.

4,6-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxypyrimidine Sodium ethoxide MALONIC ACID DI-N-BUTYL ESTER

Preparation Products

ETRIMFOS Bensulfuron methyl 2-Amino-4-Chloro-6-MethoxyPyrimidine 4,6-DIBROMOPYRIMIDINE 4-Hydroxy-6-aminopyrimidine 4-HYDRAZINO-6-HYDROXYPYRIMIDINE Chlorimuron-ethyl 2-Amino-4,6-dimethoxypyrimidine 6-Chloropyrimidin-4(3H)-one 5-BROMO-4,6-DIMETHOXYPYRIMIDINE
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View Lastest Price from 4,6-Dichloropyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4,6-Dichloropyrimidine 1193-21-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-06-28
Hebei Weibang Biotechnology Co., Ltd
Product
4,6-Dichloropyrimidine 1193-21-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
Hebei Chuanghai Biotechnology Co,.LTD
Product
4,6-Dichloropyrimidine 1193-21-1
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-20

1193-21-1, 4,6-DichloropyrimidineRelated Search:

2-Amino-4-chloro-6-methoxypyrimidine Methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate 4-Chloro-6-methyl-2-(methylthio)pyrimidine 5-amine-4,6-dichloropyrimidine,5-Amino-4,6-dichloropyrimidine, 98+% 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE 4,6-Dichloro-2-methyl-5-nitropyrimidine 2,4,6-Trichloro-5-methylpyrimidine 2,4,5,6-TETRACHLOROPYRIMIDINE 4,6-Dichloro-5-methoxypyrimidine 4,6-Dichloropyrimidine 4,6-Dichloro-5-nitropyrimidine 2-AMINO-4,6-DIHYDROXY-5-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 4,6-Dichloro-2-methylpyrimidine 2-AMINO-4,6-DICHLOROPYRIMIDINE 95+%,2-AMINO-4,6-DICHLOROPYRIMIDINE 97+% 2,4-Dichloro-5-fluoropyrimidine 4,6-Dichloro-2-(methylthio)pyrimidine 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

  • IFLAB-BB F2124-0077
  • PYRIMIDINE, 4,6-DICHLORO-
  • 4 6-DICHLOROPYRIMIDINE 99%
  • 4,6-Dichoropyrimidine
  • Pyrimidine, 4,6-dichloro- (7CI,8CI,9CI)
  • 4,6-DICHLOROPYRIMIDINE
  • 4,6-Dichloropyrimidine ,98%
  • 4,6-Dichloropyrimidine,97%
  • 4,6-Dichloropyridine
  • 4,6-Dichloropyrimidi
  • 4,6-Dichloro-1,3-diazine
  • 4,6-DichloropyriMidine, 97% 5GR
  • NSC 37530
  • 4,6-two chloropyriMidine
  • DichloropyriMidine
  • 4,6-DichL
  • 4,6-Dichlorpyrimidin
  • 4.6-Dichloropyrimidine \/DCP
  • 4,6-DIHYDROXY PYRIMIDINE 99+%
  • 4,6-Dichloropyrimidine&gt
  • Cas 1193-21-1, 4,6-dichloropyrimidine
  • 1193-21-1
  • 1193-21-2
  • Building Blocks
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  • Heterocyclic Building Blocks
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  • PyrimidinesHeterocyclic Building Blocks
  • Heterocycle-Pyrimidine series
  • alkyl chloride
  • Pyrimidines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • PYRIMIDINE
  • FINE Chemical & INTERMEDIATES
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  • Pyrazines, Pyrimidines & Pyridazines
  • Nucleotides and Nucleosides
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  • 1193-21-1