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Trifluoroacetic anhydride

Product Name
Trifluoroacetic anhydride
CAS No.
407-25-0
Chemical Name
Trifluoroacetic anhydride
Synonyms
TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;uoroacetic anhydride;trimethylamine (TMA);TRIFLUOROACETO ANHYDRIDE
CBNumber
CB6853606
Molecular Formula
C4F6O3
Formula Weight
210.03
MOL File
407-25-0.mol
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Trifluoroacetic anhydride Property

Melting point:
-65 °C (lit.)
Boiling point:
39.5-40 °C (lit.)
Density 
1.511 g/mL at 20 °C (lit.)
vapor pressure 
6.28 psi ( 20 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
-26 °C
storage temp. 
2-8°C
solubility 
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form 
Liquid
pka
0.43[at 20 ℃]
Specific Gravity
1.487
color 
Clear
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
746197
Stability:
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP
0.79 at 25℃
CAS DataBase Reference
407-25-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System
Acetic acid, trifluoro-, anhydride (407-25-0)
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Safety

Hazard Codes 
C,T
Risk Statements 
14-20-35-52/53-34-23/24/25
Safety Statements 
26-36/37/39-43-45-61-9-8-28A-27
RIDADR 
UN 3265 8/PG 1
WGK Germany 
2
RTECS 
AJ9800000
F 
3-10
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
T
HazardClass 
8
PackingGroup 
I
HS Code 
29159080
Toxicity
skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
25mL
Price
$43.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
100mL
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
106232
Product name
Trifluoroacetic anhydride
Purity
ReagentPlus , ≥99%
Packaging
10x1g
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
500mL
Price
$456
Updated
2024/03/01
Sigma-Aldrich
Product number
106232
Product name
Trifluoroacetic anhydride
Purity
ReagentPlus , ≥99%
Packaging
3kg
Price
$1460
Updated
2024/03/01
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Trifluoroacetic anhydride Chemical Properties,Usage,Production

Description

Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols. 

Chemical Properties

Clear, colorless liquid

Uses

Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.

Uses

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Preparation

Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C. 

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Raw materials

DICHLOROACETIC ANHYDRIDE Trifluoroacetic acid

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 2-Hydroxy-4-(trifluoromethyl)pyrimidine 5-Bromo-2-hydroxymethylpyridine 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 2-Chloro-4-(trifluoromethyl)pyrimidine [BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE 6-Aminobenzothiazole 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 2,6-DICHLORO-4-ISOCYANATOPYRIDINE Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)pyrazole 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE Chlorfenapyr (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine 4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 3-Nitroisonicotinic acid Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 5-Iodo-2,4-dimethoxypyrimidine N10-(TRIFLUOROACETYL)PTEROIC ACID 3-Amino-4-nitrobenzitrifluoride 2-(TRIFLUOROACETYL)THIOPHENE 2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Epirubicin 2-(Bromomethyl)-6-methylpyridine 5-Bromopyridine-2-carbaldehyde ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 3-CHLORO-5-NITROPYRIDINE [Bis(trifluoroacetoxy)iodo]benzene
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Trifluoroacetic anhydride Suppliers

Australia 2 Austria 1 Belgium 6 Brazil 1 Canada 2 China 366 Europe 4 France 4 Germany 10 India 42 Ireland 1 Italy 1 Japan 13 Norway 1 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 1 United Kingdom 20 United States 66 Global 547
Acros Organics (Part of Thermo Fisher Scientific )
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Belgium
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Solvay SA
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Belgium
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Azelis Benelux NV
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Belgium
ProdList
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Alkemi BVBA
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nfo@alkemi.be
Country
Belgium
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2201
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TCI EUROPE N.V.
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sales@tcieurope.be
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Belgium
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Acros Organics
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info@acros.com
Country
Belgium
ProdList
6772
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81
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View Lastest Price from Trifluoroacetic anhydride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Trifluoroacetic anhydride 407-25-0
Price
US $19.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
Trifluoroacetic Anhydride 407-25-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99.7%
Supply Ability
10 ton
Release date
2024-08-20
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
Trifluoroacetic anhydride 407-25-0
Price
US $25.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2t
Release date
2022-01-05

407-25-0, Trifluoroacetic anhydrideRelated Search:

Glutaric anhydride Ethyl trifluoroacetate Succinic anhydride Isatoic Anhydride Trifluoromethanesulfonic anhydride Phthalic anhydride CIS-BUTENEDIOIC ANHYDRIDE Trifluoroacetic acid Sodium trifluoroacetate Potassium trifluoroacetate Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester Trifluoromethanesulfonic acid Trifluoroacetamide Trifluoroacetophenone Trifluoroacetamidine Acetic anhydride 2,2,2-TRIFLUOROETHYL METHYL ETHER 2-Fluoroethanol Trifluoroacetic Acid Anhydride

  • TIFLUOROACETIC ANHYDRIDE
  • TRIFLUOROACETO ANHYDRIDE
  • Trifluoroacetic acid anhydride (TFAH)
  • RIFLUOROACETIC ANHYDRIDE
  • Trifluoroacetic anhydride 10g [407-25-0]
  • Trifluoroacetic anhy
  • Trifluoroacetic anhydride, min. 98%
  • trifluoroacetyl 2,2,2-trifluoroacetate
  • Trifluoroacetic anhydride, 99+% 100GR
  • Trifluoroacetic anhydride, 99+% 25GR
  • 2,2,2-Trifluoroacetic anhydride
  • Trifluoracetic anhydride, min. 98%
  • Bis(2,2,2-trifluoroacetic acid)anhydride
  • Bis(trifluoroacetic acid) anhydride
  • Di(trifluoroacetic)anhydride
  • Trifluoroacetyltrifluoroacetate
  • Trifluoroethanoicanhydride
  • TFAA
  • TRIFLUORACETIC ANHYDRIDE
  • TRIFLUOROACETIC ANHYDRIDE
  • TRIFLUOROACETIC ACID ANHYDRIDE
  • BIS(TRIFLUOROACETIC) ANHYDRIDE
  • Triflyuoroacetic anhydride
  • uoroacetic anhydride
  • Trifluoroacetic anhydride 407-25-0 fiona
  • trifluorocytic anhydride fiona
  • TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%
  • Aceticacid,trifluoro-,anhydride
  • Anhydrid kyseliny trifluoroctove
  • anhydridkyselinytrifluoroctove
  • Hexafluoroacetic anhydride
  • hexafluoroaceticanhydride
  • Perfluoroacetic anhydride
  • perfluoroaceticanhydride
  • TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
  • TRIFLUOROACETIC ANHYDRIDE, DERIVATIZA-TI ON REAGENT
  • TRIFLUOROACETIC ANHYDRIDE REAGENTPLUS(&
  • TrifluoroaceticAnhydride/Tfaa/Tfah/Trifluoroaceticanhydride
  • TrifluoroaceticAnhydride/Tfaa
  • Trifluoroacetic anhydride, 99+%
  • Trifluoraceticanhydride,min.98%
  • TRIFLUOROACETICANHYDRIDE,REAGENT
  • Trifluoressigsureanhydrid
  • Perfluoracetic anhydride
  • TRIFLUOROACETIC ANHYDRIDE: 99.5%
  • TRIFLUOROACETIC ANHYDRIDE FOR SYNTHESIS
  • TRIFLUOROACETIC ANHYDRIDE FOR GAS CHROMA
  • Trifluoroacetic anhydride 99%
  • TRIFLUOROACETIC ANHYDRINE
  • TFAH)Trifluoroacetic anhyd
  • 1,1,1,5,5,5-Hexafluoro-3-oxapentan-2,4-dione, Perfluoro(3-oxapentan-2,4-dione), 2,2,2-Trifluoroethanoic anhydride
  • Aceticacid, 2,2,2-trifluoro-, 1,1'-anhydride
  • Three fluorineacetic anhydride
  • trimethylamine (TMA)
  • Trifluoroacetic anhydride ReagentPlus(R), >=99%
  • Trifluoroacetyl 2,2,2-trifluoroacetate (Trifluoroacetic anhydride)
  • Trifluoroacetic anhydride≥ 99% (GC)
  • TFAA Trifluoroacetic acid anhydride