Trifluoroacetic anhydride
- Product Name
- Trifluoroacetic anhydride
- CAS No.
- 407-25-0
- Chemical Name
- Trifluoroacetic anhydride
- Synonyms
- TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;uoroacetic anhydride;trimethylamine (TMA);TRIFLUOROACETO ANHYDRIDE
- CBNumber
- CB6853606
- Molecular Formula
- C4F6O3
- Formula Weight
- 210.03
- MOL File
- 407-25-0.mol
Trifluoroacetic anhydride Property
- Melting point:
- -65 °C (lit.)
- Boiling point:
- 39.5-40 °C (lit.)
- Density
- 1.511 g/mL at 20 °C (lit.)
- vapor pressure
- 6.28 psi ( 20 °C)
- refractive index
- n20/D 1.3(lit.)
- Flash point:
- -26 °C
- storage temp.
- 2-8°C
- solubility
- Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
- form
- Liquid
- pka
- 0.43[at 20 ℃]
- Specific Gravity
- 1.487
- color
- Clear
- Water Solubility
- Hydrolysis
- Sensitive
- Moisture Sensitive
- BRN
- 746197
- Stability:
- Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
- LogP
- 0.79 at 25℃
- CAS DataBase Reference
- 407-25-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, trifluoro-, anhydride(407-25-0)
- EPA Substance Registry System
- Acetic acid, trifluoro-, anhydride (407-25-0)
Safety
- Hazard Codes
- C,T
- Risk Statements
- 14-20-35-52/53-34-23/24/25
- Safety Statements
- 26-36/37/39-43-45-61-9-8-28A-27
- RIDADR
- UN 3265 8/PG 1
- WGK Germany
- 2
- RTECS
- AJ9800000
- F
- 3-10
- Hazard Note
- Corrosive/Moisture Sensitive
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- I
- HS Code
- 29159080
- Toxicity
- skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 8.08261
- Product name
- Trifluoroacetic anhydride
- Purity
- for synthesis
- Packaging
- 25mL
- Price
- $43.7
- Updated
- 2024/03/01
- Product number
- 8.08261
- Product name
- Trifluoroacetic anhydride
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $114
- Updated
- 2024/03/01
- Product number
- 106232
- Product name
- Trifluoroacetic anhydride
- Purity
- ReagentPlus , ≥99%
- Packaging
- 10x1g
- Price
- $212
- Updated
- 2024/03/01
- Product number
- 8.08261
- Product name
- Trifluoroacetic anhydride
- Purity
- for synthesis
- Packaging
- 500mL
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 106232
- Product name
- Trifluoroacetic anhydride
- Purity
- ReagentPlus , ≥99%
- Packaging
- 3kg
- Price
- $1460
- Updated
- 2024/03/01
Trifluoroacetic anhydride Chemical Properties,Usage,Production
Description
Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols.
Chemical Properties
Clear, colorless liquid
Uses
Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Uses
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Preparation
Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
Safety Profile
A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods
Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]
Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
Trifluoroacetic anhydride Suppliers
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View Lastest Price from Trifluoroacetic anhydride manufacturers
- Product
- Trifluoroacetic anhydride 407-25-0
- Price
- US $19.90/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Trifluoroacetic Anhydride 407-25-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.7%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20
- Product
- Trifluoroacetic anhydride 407-25-0
- Price
- US $25.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2t
- Release date
- 2022-01-05