ChemicalBook > CAS DataBase List > Methylamine hydrochloride

Methylamine hydrochloride

Product Name
Methylamine hydrochloride
CAS No.
593-51-1
Chemical Name
Methylamine hydrochloride
Synonyms
MACl;METHYLAMINE HCL;METHYLAMMONIUM CHLORIDE;CH3NH3Cl;Methyl-ammonium;MONOMETHYLAMINE HCL;Methanaminium chloride;AMINOMETHANE HYDROCHLORIDE;MACI;LT-S9151
CBNumber
CB7122563
Molecular Formula
CH5N.ClH
Formula Weight
67.52
MOL File
593-51-1.mol
More
Less

Methylamine hydrochloride Property

Melting point:
231-233 °C(lit.)
Boiling point:
225-230 °C15 mm Hg(lit.)
Density 
0.8306 (rough estimate)
bulk density
1100kg/m3
vapor pressure 
0.134Pa at 25℃
refractive index 
1.5500 (estimate)
Flash point:
225-230°C/15mm
storage temp. 
Store below +30°C.
solubility 
soluble
form 
powder
color 
White crystalline
Odor
Odorless
PH Range
5 - 7 at 10 g/l at 20 °C
PH
5-7 (10g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,6014
BRN 
3588822
Stability:
Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents.
InChIKey
NQMRYBIKMRVZLB-UHFFFAOYSA-N
LogP
-3.82
CAS DataBase Reference
593-51-1(CAS DataBase Reference)
NIST Chemistry Reference
Methylammonium chloride(593-51-1)
EPA Substance Registry System
Methylamine hydrochloride (593-51-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-37/39
WGK Germany 
1
RTECS 
PA0603000
F 
10
TSCA 
Yes
HS Code 
29211190
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0505
Product name
Methylamine hydrochloride
Purity
≥98%
Packaging
100g
Price
$29.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
5G
Price
$33.2
Updated
2025/07/31
Sigma-Aldrich
Product number
M0505
Product name
Methylamine hydrochloride
Purity
≥98%
Packaging
500g
Price
$141
Updated
2025/07/31
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
250g
Price
$62.4
Updated
2025/07/31
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
1kg
Price
$181
Updated
2025/07/31
More
Less

Methylamine hydrochloride Chemical Properties,Usage,Production

Description

Methylamine Hydrochloride is a colorless organic solid that has an odor similar to that of fish and is used as an essential part for the synthesis of a wide variety of commercial compounds such as ephedrine, theophylline and other intermediates for a wide range of agricultural chemicals, including herbicides, fungicides, insecticides, biocides, and miticides. Methylamine hydrochloride is also a key ingredient in the synthesis of methamphetamine

Chemical Properties

white to light tan solid

Uses

Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.
The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.

Application

Methylamine hydrochloride can be used as a reactant to synthesize:
Betahistine via aza-Michael reaction with 2-vinylpyridine in water.
Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction.
Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes.
N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.

Definition

ChEBI: The hydrochloride formed from methylamine.

Preparation

Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.

Pharmacology

Methylamine hydrochloride reduces blood pressure in both normotensive and hypertensive individuals. It has a gradual onset of action (1/2 to 2 hours) and a long-lasting effect (usually 6 to 12 hours or more). A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced.

Solubility in organics

Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform.

Solubility in water

The experimental water solubility of Methylamine hydrochloride at 20 ℃ was 1080mg/L. Methylamine hydrochloride is highly soluble in water.

storage

Keep in a dry, cool and well-ventilated place. Keep container tightly close

Purification Methods

Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]

Toxics Screening Level

The initial threshold screening level (ITSL) for methylamine hydrochloride is 140 μg/m3 with an 8-hr averaging time.

Methylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-1,2-benzenediamine dihydrochloride 1-METHYL-1H-IMIDAZOLE-5-CARBOXALDEHYDE 4-N-Boc-4-N-Methyl-aminopiperidine Betahistine N-METHYL-2-NITROANILINE 1-Methyl-4-(methylamino)piperidine 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE 1-Boc-4-Methylaminopiperidine
More
Less

Methylamine hydrochloride Suppliers

Americas 1 Belgium 2 Canada 1 China 541 China Hong Kong 1 Europe 3 France 1 Germany 5 India 49 Japan 5 Poland 1 Slovakia 1 Switzerland 2 United Kingdom 10 United States 42 Global 665
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
RSA Corporation
Tel
--
Fax
--
Email
media@RSAgroup.ca
Country
United States
ProdList
343
Advantage
58
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
Sinco Pharmachem Inc.
Tel
--
Fax
--
Email
info@sincopharmachem.com
Country
United States
ProdList
37
Advantage
58
Moravek, Inc.
Tel
--
Fax
--
Email
info@moravek.com
Country
United States
ProdList
279
Advantage
58
Pennbio Chemicals (U.S.A.)
Tel
--
Fax
--
Country
United States
ProdList
240
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Garuda Chemicals
Tel
--
Fax
--
Email
manufacturing@garudachem.com
Country
United States
ProdList
70
Advantage
56
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
AccuStandard Inc
Tel
--
Fax
--
Email
info@bester.nl
Country
United States
ProdList
5300
Advantage
76
Daniel Lab Canada
Tel
--
Fax
--
Country
United States
ProdList
273
Advantage
50
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Naugra Export
Tel
--
Fax
--
Country
United States
ProdList
1332
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Loba Chemie Pvt. Ltd.
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
71
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Esprit Chemical Company
Tel
--
Fax
--
Email
admin@esprixtech.com
Country
United States
ProdList
1616
Advantage
55
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
More
Less

View Lastest Price from Methylamine hydrochloride manufacturers

Hebei Dangtong Import and export Co LTD
Product
Methylamine hydrochloride 593-51-1
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
300tons
Release date
2025-11-03
RongNa Biotechnology Co.,Ltd
Product
Methylamine HCL 593-51-1
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 tons
Release date
2025-05-04
RongNa Biotechnology Co.,Ltd
Product
Methylamine HCL powder 593-51-1
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 tons
Release date
2025-05-04

593-51-1, Methylamine hydrochlorideRelated Search:

Meglumine Sodium chloride Polyvinyl chloride Methylamine Ferric chloride Sulfuryl chloride Trimethylamine Aminodiphenylmethane hydrochloride Calcium chloride Ammonium chloride Dimethylamine hydrochloride Flunixin meglumine Benzhydrylamine Trimethylamine hydrochloride Topotecan hydrochloride trimethylamine oxide SILIBININ-N-METHYLGLUCAMINE, 95％ （HPLC） Potassium chloride Methylamine Hcl

  • Methylamine-hydrogenchloride(1/1)
  • Methyl-ammonium
  • MERCURIALIN HYDROCHLORIDE
  • METHYLAMINE HYDROCHLORIDE
  • METHYLAMINE HCL
  • METHYLAMMONIUM CHLORIDE
  • AMINOMETHANE HYDROCHLORIDE
  • MethylaMine hydrochloride, 99% 250GR
  • MONOMETHYLAMINE HCL
  • MONOMETHYLAMINE HYDROCHLORIDE
  • CH3NH3Cl(MACl)
  • MethylaMine hydrochloride, CP,97.0%
  • Metformin Impurity 12
  • SUPPLY METHYLAMINE HYDROCHLORIDE 99% POWDER FOR CHEMICAL SYNTHESIS 593-51-1
  • rimethylamine hydrochlorate
  • Methylamine hydrochloride Vetec(TM) reagent grade, 98%
  • MACl
  • Methylamine H20
  • Methanamine, hydrochloride (1:1)
  • Methylammonium Chloride Solution
  • methy hcl 593-51-1 kf-wang(at)kf-chem.com
  • Methylamine Hydrochloride / Methylamine HCl
  • METHYLAMINE CHLORHYDRATE
  • Monomethylamin hydrochloride
  • METHYLAMINE HYDROCHLORIDE, 99+%
  • MethylAmmoniumChlorideForSynthesis
  • Methylamine Hydrochloride 99%
  • Methylaminehydrochloride,98%
  • Methylammonium Cloride
  • monomethylammonium chloride
  • Methylamine-methyl-D3HCl
  • Methylammoniumchlorid
  • Methanaminium chloride
  • Methylamine-methyl-D3Cl
  • Methaneaminium
  • Methaniminium
  • Methylaminium
  • Methylamine hydrochloride Methylammonium chloride
  • Methylammonium chloride, synthesis grade
  • Methylamine hydrochloride 2g [593-51-1]
  • Methylamine hydrochl
  • A MethylaMine hydrochloride
  • MethylamineHydrochloride&gt
  • Methylamine HCL powder
  • YLmethylamine hydrochloride
  • Methylamine hydrochloride 99.5%
  • LT-S9151
  • Methylamine hydrochloride ISO 9001：2015 REACH
  • CH3NH3Cl
  • 99% Methylamine HCL Powder
  • Methylamine Hydrochloride Methylamine HCl Powder
  • methylamine HCl 1
  • Methylamine HClQ: What is Methylamine HCl Q: What is the CAS Number of Methylamine HCl Q: What is the storage condition of Methylamine HCl Q: What are the applications of Methylamine HCl
  • Pharmaceutical Intermediate HCl
  • 98%，extra pure
  • Monomethylamine hydrochloride brine solution
  • methoxy methyl ammonium chloride
  • Methylamine hydrochloride/hcl