ChemicalBook > CAS DataBase List > 4-Bromophenol

4-Bromophenol

Product Name
4-Bromophenol
CAS No.
106-41-2
Chemical Name
4-Bromophenol
Synonyms
P-BROMOPHENOL;Para Bromo Phenol;4-Bromphenol;Phenol, 4-bromo-;NSC 4970;p-Bromphenol;4-BROMOPHENOL;BROMOPHENOL-4;P-Bromophenlo;4-bromo-pheno
CBNumber
CB7181317
Molecular Formula
C6H5BrO
Formula Weight
173.01
MOL File
106-41-2.mol
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4-Bromophenol Property

Melting point:
61-64 °C (lit.)
Boiling point:
235-236 °C (lit.)
Density 
1.84
refractive index 
1.5085 (estimate)
Flash point:
235-238°C
storage temp. 
room temp
solubility 
14g/l
form 
Crystalline Solid
pka
9.37(at 25℃)
color 
Pinkish-brown
Water Solubility 
It is insoluble in water. It is soluble in 5%ethanol.
λmax
282nm(EtOH)(lit.)
Merck 
14,1428
BRN 
1680024
CAS DataBase Reference
106-41-2(CAS DataBase Reference)
NIST Chemistry Reference
4-Bromophenol(106-41-2)
EPA Substance Registry System
Phenol, 4-bromo- (106-41-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-37/39-36
RIDADR 
2811
WGK Germany 
2
RTECS 
SJ7960000
F 
8-10-23
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29081000
Hazardous Substances Data
106-41-2(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,411mg/kg (411mg/kg),Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(12), Pg. 19, 1979.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B75808
Product name
4-Bromophenol
Purity
99%
Packaging
5g
Price
$37.5
Updated
2024/03/01
Sigma-Aldrich
Product number
B75808
Product name
4-Bromophenol
Purity
99%
Packaging
100g
Price
$76.3
Updated
2024/03/01
TCI Chemical
Product number
B0787
Product name
4-Bromophenol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
B0787
Product name
4-Bromophenol
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$33
Updated
2024/03/01
Alfa Aesar
Product number
A14873
Product name
4-Bromophenol, 99%
Packaging
100g
Price
$61.8
Updated
2024/03/01
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4-Bromophenol Chemical Properties,Usage,Production

Chemical Properties

4-Bromophenol is a pinkish-brown crystalline solid. four-sided biconical crystal precipitated from ether or chloroform. The melting point is 66.4 ℃, and a small amount of water can reduce the melting point a lot. Soluble in water, chloroform, easily soluble in ethanol, ether and glacial acetic acid, soluble in 7 parts of water.

Uses

4-Bromophenol is used as an intermediate in medicine grade. It is also used as a phenol that is used in Stille reactions. It is used in the intermediate of organic synthesis, flame retardant and pharmaceutical industry.

Application

4-Bromophenol is a phenolic derivative that It can used as a reagent in Stille reactions or Intermediates of Liquid Crystals.

Preparation

4-Bromophenol is synthesized by bromination of phenol. The bromine and carbon disulfide solution was added to the phenolic carbon disulfide solution, and the addition was started below 5°C, and the addition was completed under stirring for 2 hours. Phenol and bromine are approximately equimolar ingredients. Distill the reactant to remove carbon disulfide, and then conduct fractional distillation under reduced pressure to collect fractions at 145-150°C (3.32-3.99kPa) to obtain the product. Yield 80-84%.

Definition

ChEBI: 4-bromophenol is a bromophenol containing only hydroxy and bromo substituents that are para to one another. It has a role as a mouse metabolite, a persistent organic pollutant, a human xenobiotic metabolite, a rat metabolite, a human urinary metabolite and a marine metabolite.

Synthesis Reference(s)

Tetrahedron, 45, p. 7869, 1989 DOI: 10.1016/S0040-4020(01)85800-2
The Journal of Organic Chemistry, 23, p. 280, 1958 DOI: 10.1021/jo01096a033

Purification Methods

Crystallise the phenol from CHCl3, CCl4, pet ether (b 40-60o), or water and dry it at 70o under vacuum for 2hours. [Beilstein 6 IV 1043.]

4-Bromophenol Preparation Products And Raw materials

Raw materials

Carbon disulfide Government regulation

Preparation Products

1-BENZOFURAN-5-CARBONITRILE BENZOFURAN-5-BORONIC ACID 5-BROMO-2(3H)-BENZOXAZOLONE 4-Bromoanisole 6-Bromo-2,3-dihydro-4H-chromen-4-one 1-Benzofuran-5-carbaldehyde N-[2-(4-Bromophenoxy)ethyl]pyrrolidine 4-Benzyloxybenzeneboronic acid 4-ISOBUTOXYPHENYLBORONIC ACID 4-Bromo-2-nitrophenol 5-BROMO-2-BENZOXAZOLINONE 97 4-Hydroxyphenylboronic acid 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE 4-Bromo-2-chlorophenol Tamoxifen citrate O,O-Di(4-bromophenyl)thiophosphoryl chloride 2-Amino-4-bromophenol 5-Bromo-1-benzofuran 3-(4-BROMOPHENOXY)PROPANOIC ACID 6-bromo-3,4-dihydro-2H-chromen-4-ol
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4-Bromophenol Suppliers

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View Lastest Price from 4-Bromophenol manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
P-Bromophenol 106-41-2
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-09-29
Hebei Weibang Biotechnology Co., Ltd
Product
4-Bromophenol 106-41-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Bromophenol 106-41-2
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-09-20

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