2-Amino-4-chloropyridine
- Product Name
- 2-Amino-4-chloropyridine
- CAS No.
- 19798-80-2
- Chemical Name
- 2-Amino-4-chloropyridine
- Synonyms
- 4-CHLOROPYRIDIN-2-AMINE;4-chloro-2-pyridinamine;4-CHLORO-PYRIDINE-2-YLAMINE;DK765;cas:19798-80-2;IFLAB-BB F1926-0004;4-Chloropyrid-2-ylaMine;2-AMINO-4-CHLOROPYRIDINE;4-Chloro-2-aminopyridine;4-Chloro-2-amine-pyridin
- CBNumber
- CB7183078
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 19798-80-2.mol
2-Amino-4-chloropyridine Property
- Melting point:
- 126-127°C
- Boiling point:
- 240.8±20.0 °C(Predicted)
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 5.72±0.11(Predicted)
- form
- Liquid
- color
- Colorless to yellow to brown
- λmax
- 294nm(CHCl3)(lit.)
- Sensitive
- Air & Moisture Sensitive
- InChI
- InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
- InChIKey
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC(Cl)=C1
- CAS DataBase Reference
- 19798-80-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 676020
- Product name
- 2-Amino-4-chloropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $70.1
- Updated
- 2023/06/20
- Product number
- 676020
- Product name
- 2-Amino-4-chloropyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $195
- Updated
- 2023/06/20
- Product number
- A2152
- Product name
- 2-Amino-4-chloropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $79
- Updated
- 2024/03/01
- Product number
- A2152
- Product name
- 2-Amino-4-chloropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $237
- Updated
- 2024/03/01
- Product number
- H59130
- Product name
- 2-Amino-4-chloropyridine, 97%
- Packaging
- 5g
- Price
- $54.65
- Updated
- 2024/03/01
2-Amino-4-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Amino-4-chloropyridine is a useful precursor that could be used to synthesize 2-amino-4,5-dichloropyridine, 2-amino-3,4-dichloropyridine, and 2-amino-3,4,5-trichloropyridine[1].
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Synthesis
Methyl 4-chloropicolinate hydrochloride in methanol was treated with hydrazine hydrate, resulting in the formation of a precipitate. The suspension was then stirred for 2 hours and the precipitated hydrazide was collected through filtration. The hydrazide was dissolved in 1N hydrochloric acid and the solution was cooled to a temperature between 0-5 ℃. A solution of sodium nitrite in water was then added dropwise, causing another precipitate to form. After stirring for 15 minutes, the precipitate was collected by filtration and washed with water. The moist precipitate was then combined with a mixture of acetic acid and water, and the resulting solution was heated in a steam bath until gas evolution stopped. The reaction mixture was cooled to room temperature, the pH was adjusted to 7, and the resulting precipitate was collected via filtration. Recrystallization using ethanol yielded 2-Amino-4-chloropyridine in the form of a white crystalline solid[1].
References
[1] Gudmundsson, Kristjan S. , et al. "An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines." Synthetic Communications 27.5(1997):861-870.
2-Amino-4-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4-chloropyridine Suppliers
View Lastest Price from 2-Amino-4-chloropyridine manufacturers
- Product
- 2-Amino-4-chloropyridine 19798-80-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.10%
- Supply Ability
- 50000kg
- Release date
- 2024-04-23
- Product
- 2-Amino-4-chloropyridine 19798-80-2
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 50000tons
- Release date
- 2024-04-11
- Product
- 4-Chloropyridin-2-amine 19798-80-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30