ChemicalBook > CAS DataBase List > Pomalidomide-PEG2-butyl iodide

Pomalidomide-PEG2-butyl iodide

Product Name
Pomalidomide-PEG2-butyl iodide
CAS No.
1835705-72-0
Chemical Name
Pomalidomide-PEG2-butyl iodide
Synonyms
Pomalidomide-2-2-6-I;Pomalidomide-PEG2-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-2-{2-[(6-iodohexyl)oxy]ethoxy}acetamide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-;Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber
CB74919985
Molecular Formula
C23H28IN3O7
Formula Weight
585.39
MOL File
1835705-72-0.mol
More
Less

Pomalidomide-PEG2-butyl iodide Property

Boiling point:
757.7±60.0 °C(Predicted)
Density 
1.588±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.68±0.40(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
904724
Product name
Pomalidomide-PEG2-butyl iodide
Purity
≥95%
Packaging
50MG
Price
$558
Updated
2023/06/20
More
Less

Pomalidomide-PEG2-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-butyl iodide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pomalidomide-PEG2-butyl iodide Suppliers

China 11 United States 1 Global 12
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
More
Less

View Lastest Price from Pomalidomide-PEG2-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-2-2-6-I 1835705-72-0
Price
US $0.00/mg
Min. Order
100mg
Purity
>95.00%
Supply Ability
100mg
Release date
2024-04-01

1835705-72-0, Pomalidomide-PEG2-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG4-azide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG2-N3

  • Pomalidomide-PEG2-butyl iodide
  • Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[2-[(6-iodohexyl)oxy]ethoxy]-
  • Pomalidomide-2-2-6-I
  • Crosslinker–E3 Ligase ligand conjugate, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-2-{2-[(6-iodohexyl)oxy]ethoxy}acetamide
  • 1835705-72-0
  • C23H28IN3O7