Pomalidomide-PEG2-N3

Product Name: Pomalidomide-PEG2-N3
CAS No.: 2267306-14-7
Chemical Name: Pomalidomide-PEG2-N3
Synonyms: N3-PEG2-CH2CO-Poma;Pomalidomide-PEG2-N3;Pomalidomide-NH-CO-PEG2-N3;Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber: CB78118456
Molecular Formula: C19H20N6O7
Formula Weight: 444.4
MOL File: 2267306-14-7.mol

More

Less

Pomalidomide-PEG2-N3 Property

Melting point:: 188 °C
storage temp.: 2-8°C
solubility: DMSO: 90 mg/mL (202.52 mM)
form: Solid
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 903833
Product name: Pomalidomide-PEG2-azide
Packaging: 50MG
Price: $538.2
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1530
Product name: Pomalidomid-PEG2-N3
Packaging: 50mg
Price: $607.5
Updated: 2021/12/16

More

Less

Pomalidomide-PEG2-N3 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-N3 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Pomalidomide-PEG2-N3 Suppliers

China 14 United States 1 Global 15

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

More

Less

View Lastest Price from Pomalidomide-PEG2-N3 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-NH-CO-PEG2-N3 2267306-14-7
Price: US $0.00/mg
Min. Order: 500mg
Purity: >99.00%
Supply Ability: 500mg
Release date: 2024-04-01

2267306-14-7, Pomalidomide-PEG2-N3Related Search:

Pomalidomide-PEG1-azide Pomalidomide-PEG3-N3 E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG4-azide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG2-butyl iodide Pomalidomide-NH-CO-PEG6-N3 Pomalidomide-PEG5-N3

Pomalidomide-PEG2-N3

Pomalidomide-NH-CO-PEG2-N3

2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

N3-PEG2-CH2CO-Poma

Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide

2267306-14-7