3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Name: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.: 151266-23-8
Chemical Name: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms: 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;IbrutinibIntermediate6;7-Iodo-7-deaza-8-aza-adenine;4-AMINO-3-IODO-1H-PYRAZOLO[3;4-AMino-3-iodopyrazolo[3,4-d]pyridine;3-iodo-4-Aminopyrazolo[3,4-d]pyridine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
CBNumber: CB8144555
Molecular Formula: C5H4IN5
Formula Weight: 261.02
MOL File: 151266-23-8.mol

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3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property

Boiling point:: 312.3±52.0 °C(Predicted)
Density: 2.92±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 10.50±0.20(Predicted)
color: White to Light yellow to Light orange
Sensitive: Light Sensitive
λmax: 282nm(lit.)
InChI: InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
InChIKey: HQAIUXZORKJOJY-UHFFFAOYSA-N
SMILES: C1=NC(N)=C2C(I)=NNC2=N1

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-37
TSCA: N
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I0941
Product name: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $61
Updated: 2024/03/01

TCI Chemical

Product number: I0941
Product name: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $300
Updated: 2024/03/01

Alfa Aesar

Product number: H52572
Product name: 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine, 97%
Packaging: 250mg
Price: $144
Updated: 2021/12/16

TRC

Product number: I736005
Product name: 3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
Packaging: 1g
Price: $105
Updated: 2021/12/16

TRC

Product number: I736005
Product name: 3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
Packaging: 25g
Price: $1765
Updated: 2021/12/16

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3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production

Uses

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Synthesis

A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

Americas 1 Belgium 1 Canada 1 China 279 Europe 1 France 1 Germany 6 India 16 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 40 Global 358

Novachemistry

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Apollo Scientific Ltd.

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View Lastest Price from 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturers

Nanjing Fred Technology Co., Ltd

Product: 4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine 151266-23-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

Henan Fengda Chemical Co., Ltd

Product: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 151266-23-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Dideu Industries Group Limited

Product: 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 151266-23-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-06

151266-23-8, 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Related Search:

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IbrutinibIntermediate6

151266-23-8

Heterocycle-Pyridine series

pharmacetical