ChemicalBook > CAS DataBase List > 2-Fluoroisonicotinic acid

2-Fluoroisonicotinic acid

Product Name
2-Fluoroisonicotinic acid
CAS No.
402-65-3
Chemical Name
2-Fluoroisonicotinic acid
Synonyms
uoroisonicotinic Acid;2-FluoroisonicotinicAci;2-Fluoroisonotinic acid;2-Fluoroisonictinic acid;2-FLUOROISONICOTINIC ACID;2-FluoroisonicotinicAcid>2-Fluoro-4-pyridinecorboxylc;2-Fluoroisonicotinic acid ,98%;2-Fluoro-4-pyridinecarboxlic acid;2-Fluoropyridin-4-carboxylic acid
CBNumber
CB8213068
Molecular Formula
C6H4FNO2
Formula Weight
141.1
MOL File
402-65-3.mol
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2-Fluoroisonicotinic acid Property

Melting point:
200 °C (dec.)(lit.)
Boiling point:
396.6±22.0 °C(Predicted)
Density 
1.419±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.03±0.10(Predicted)
form 
Powder
color 
White to Almost white
InChI
InChI=1S/C6H4FNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
InChIKey
JMPFWDWYGOWUFP-UHFFFAOYSA-N
SMILES
C1(F)=NC=CC(C(O)=O)=C1
CAS DataBase Reference
402-65-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
593885
Product name
2-Fluoro-4-pyridinecarboxylic acid
Purity
97%
Packaging
250mg
Price
$82.3
Updated
2023/01/07
TCI Chemical
Product number
F0693
Product name
2-Fluoroisonicotinic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
F0693
Product name
2-Fluoroisonicotinic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$63
Updated
2025/07/31
TRC
Product number
F596268
Product name
2-Fluoropyridine-4-carboxylicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
F596268
Product name
2-Fluoropyridine-4-carboxylicacid
Packaging
500mg
Price
$65
Updated
2021/12/16
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2-Fluoroisonicotinic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder, solubility in water, ethanol, and methanol, as well as high solubility in organic solvents. 

Uses

2-Fluoroisonicotinic acid is a catalyst in organic reactions and serves as a starting material for the synthesis of fluorinated compounds. Furthermore, it plays a role in the synthesis of dyes, pigments, and various other organic compounds.

Synthesis

461-87-0

402-65-3

General procedure for the preparation of 2-fluoroisonicotinic acid: 1. 5.00 g (45 mmol) of 2-fluoro-4-methylpyridine and 1.00 g (17 mmol) of KOH were added to a reaction flask followed by 50 ml of pyridine as solvent. 2. The reaction mixture was heated to reflux. 3. 20.00 g (127 mmol) of potassium permanganate was added in batches over 30 minutes at reflux temperature. 4. After addition, the reaction mixture was continued to be heated at reflux for 1.5 hours. 5. Upon completion of the reaction, the mixture was cooled to room temperature in an ice bath. 6. 100 ml of water was added to the cooled mixture and the pH was subsequently adjusted to 1 with concentrated hydrochloric acid. 7. 100 ml of ethyl acetate was added and the insoluble material was removed by filtration. 8. The aqueous phase was extracted twice with ethyl acetate, 100 ml each time. 9. Combine all ethyl acetate phases and dry with magnesium sulfate. 10. The dried organic phase was concentrated under pressure to give 2.70 g of 2-fluoroisonicotinic acid. Yield: 42%.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 8, p. 2745 - 2766
[2] Patent: US6358978, 2002, B1
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[4] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 4152

2-Fluoroisonicotinic acid Preparation Products And Raw materials

Raw materials

Nitrogen Sodium nitrite Fluoroboric acid Potassium permanganate 4-Methylpyridin-2-amine Nitroethane

Preparation Products

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2-Fluoroisonicotinic acid Suppliers

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View Lastest Price from 2-Fluoroisonicotinic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Fluoroisonicotinic acid 402-65-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Fluoroisonicotinic acid 402-65-3
Price
US $0.00/G
Min. Order
100G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-03
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Fluoroisonicotinic acid 402-65-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30

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