Azide-PEG3-Tos
- Product Name
- Azide-PEG3-Tos
- CAS No.
- 178685-33-1
- Chemical Name
- Azide-PEG3-Tos
- Synonyms
- 2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;N?-PEG?-OTs;N3-PEG3-OTs;N3-PEG3-Tos;N3-PEG3-OTos;Azide-PEG3-Tos;Azido-PEG3-Ots;Ethylene glycol 2-azidoethyl ether tosylate;Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester;Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 4-methylbenzenesulfonate (ester)
- CBNumber
- CB83062331
- Molecular Formula
- C13H19N3O5S
- Formula Weight
- 329.37
- MOL File
- 178685-33-1.mol
Azide-PEG3-Tos Property
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C13H19N3O5S/c1-12-2-4-13(5-3-12)22(17,18)21-11-10-20-9-8-19-7-6-15-16-14/h2-5H,6-11H2,1H3
- InChIKey
- PTOJCKLTCKYNFG-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(C)=CC=1)(=O)(=O)OCCOCCOCCN=[N+]=[N-]
N-Bromosuccinimide Price
- Product number
- BP-22769
- Product name
- Azide-PEG3-Tos
- Purity
- 98%
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- AS107893
- Product name
- N3-PEG3-Tos
- Purity
- 97%
- Packaging
- 1g
- Price
- $618
- Updated
- 2021/12/16
- Product number
- BP-22769
- Product name
- Azide-PEG3-Tos
- Purity
- 98%
- Packaging
- 1g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- BIPG1094
- Product name
- Azide-PEG3-Tos
- Packaging
- 250mg
- Price
- $753
- Updated
- 2021/12/16
- Product number
- 179948
- Product name
- 2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1403
- Updated
- 2021/12/16
Azide-PEG3-Tos Chemical Properties,Usage,Production
Description
Azide-PEG3-Tos is a heterobifunctional PEG linker.The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Tosyl group is a good leaving group for nucleophilic substitution reactions.
Uses
Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Non-cleavable Linker
References
[1] Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431. DOI:10.1021/ma4005633
[2] Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.
Azide-PEG3-Tos Preparation Products And Raw materials
Raw materials
Preparation Products
Azide-PEG3-Tos Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
View Lastest Price from Azide-PEG3-Tos manufacturers
- Product
- 2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 178685-33-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- Azido-PEG3-Tos 178685-33-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23