ChemicalBook > CAS DataBase List > 1-Bromo-3-chloropropane

1-Bromo-3-chloropropane

Product Name
1-Bromo-3-chloropropane
CAS No.
109-70-6
Chemical Name
1-Bromo-3-chloropropane
Synonyms
BROMOCHLOROPROPANE;3-Chloro-1-bromopropane;I-BCP;1,3-BCP;CHLOROBROMOPROPANE;3-Bromo-1-chloropropane;1-CHLORO-3-BROMOPROPANE;NSC 9183;1,3-Chbp;ω-Chlorobr
CBNumber
CB8700201
Molecular Formula
C3H6BrCl
Formula Weight
157.44
MOL File
109-70-6.mol
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1-Bromo-3-chloropropane Property

Melting point:
-59 °C
Boiling point:
144-145 °C (lit.)
Density 
1.592 g/mL at 25 °C (lit.)
vapor pressure 
7.5 hPa (20 °C)
refractive index 
n20/D 1.486(lit.)
Flash point:
81 °C
storage temp. 
room temp
solubility 
2.24g/l insoluble
form 
liquid
color 
Clear liquid
explosive limit
3.2-8.6%(V)
Water Solubility 
insoluble
BRN 
605278
Stability:
Volatile
CAS DataBase Reference
109-70-6(CAS DataBase Reference)
NIST Chemistry Reference
Propane, 1-bromo-3-chloro-(109-70-6)
IARC
2B (Vol. 125)
EPA Substance Registry System
Propane, 1-bromo-3-chloro- (109-70-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
10-22-36/37/38-20/21/22-20/22-68-52/53-37
Safety Statements 
16-45-36/37/39-26
RIDADR 
UN 2688 6.1/PG 3
WGK Germany 
3
RTECS 
TX4113000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29034980
Hazardous Substances Data
109-70-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H331Toxic if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H350May cause cancer

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B62404
Product name
1-Bromo-3-chloropropane
Purity
99%
Packaging
250g
Price
$49
Updated
2024/03/01
Sigma-Aldrich
Product number
B62404
Product name
1-Bromo-3-chloropropane
Purity
99%
Packaging
1kg
Price
$134
Updated
2024/03/01
TCI Chemical
Product number
B0575
Product name
1-Bromo-3-chloropropane
Purity
>99.0%(GC)
Packaging
25g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
B0575
Product name
1-Bromo-3-chloropropane
Purity
>99.0%(GC)
Packaging
500g
Price
$53
Updated
2024/03/01
Alfa Aesar
Product number
A11395
Product name
1-Bromo-3-chloropropane, 99%
Packaging
100g
Price
$23.5
Updated
2024/03/01
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1-Bromo-3-chloropropane Chemical Properties,Usage,Production

Description

1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.

Chemical Properties

It is a clear and colorless liquid that is soluble in ethanol, ether, and chloroform but insoluble in water.

Uses

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Definition

ChEBI: 1-Bromo-3-chloropropane (I-BCP or 109-70-6) is an organochlorine compound that can be used as a safer and equally effective alternative to chloroform. It serves as a phase-separation agent for the one-step method of RNA isolation from biological samples like animal and plant tissue. I-BCP can replace CHCl3 in RNA phase separations.

Preparation

The most common method for producing 1-Bromo-3-chloropropane is through the free-radical addition of anhydrous hydrogen bromide to allyl chloride. Alternatively, it can be prepared by reacting ethylene with methylene chlorobromide.

General Description

1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Some of these materials may burn, but none ignite readily. Containers may explode when heated.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.

Purification Methods

Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]

1-Bromo-3-chloropropane Preparation Products And Raw materials

Raw materials

Benzoyl peroxide Hydrogen bromide Allyl chloride

Preparation Products

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Chlorpromazine hydrochloride 1,1-Cyclobutanedicarboxylic acid ACETOPHENAZINE MALEATE (200 MG) 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Julolidine Oxatomide 3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN LOMIFYLLINE Nefazodone Cyclobutanemethanol Azetidine 4-Chlorobutyronitrile (Bromomethyl)cyclobutane 1-Bromo-5-hexanone 1-(3-(pyrrolidin-1-yl)propyl)hydrazine Pentoxifylline PERPHENAZINE Difenidol hydrochloride SEMOTIADIL Azetidine hydrochloride Tirofiban (3-MORPHOLIN-4-YL-PROPYL)-HYDRAZINE 1-(3-Hydrazinylpropyl)pyrrolidin-2-one
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View Lastest Price from 1-Bromo-3-chloropropane manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
1-Bromo-3-chloropropane 109-70-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-04
Hebei Yanxi Chemical Co., Ltd.
Product
1-Bromo-3-chloropropane 109-70-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
1-Bromo-3-chloropropane 109-70-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 ton
Release date
2024-08-20

109-70-6, 1-Bromo-3-chloropropaneRelated Search:

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  • 3-Chloro-1-bromopropane
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  • 1-Bromo-3-chL
  • 1-Bromo-3-Chloropropane,>98%
  • trimethylenbromchlorid
  • CHLOROBROMOPROPANE
  • 1-Brom-3-chlorpropan
  • 1-Bromo 3-Chlorooropane
  • I-BCP, Trimethylene bromochloride, Trimethylene chlorobromide
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