ChemicalBook > CAS DataBase List > 4-Amino-1-Boc-piperidine

4-Amino-1-Boc-piperidine

Product Name
4-Amino-1-Boc-piperidine
CAS No.
87120-72-7
Chemical Name
4-Amino-1-Boc-piperidine
Synonyms
TERT-BUTYL 4-AMINOPIPERIDINE-1-CARBOXYLATE;1-BOC-4-AMINOPIPERIDINE;N-BOC-4-AMINOPIPERIDINE;1-BUTYLOXYCARBONYL-4-AMINO-PIPERIDINE;4-Amino-piperidine-1-carboxylic acid t-butyl ester;4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;EOS-61525;1-BOC-4-AMI;BOC-PIP(4-NH2);BUTTPARK 90\06-10
CBNumber
CB8758747
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
87120-72-7.mol
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4-Amino-1-Boc-piperidine Property

Melting point:
50°C
Boiling point:
80/0.037mm
Density 
1.041±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
10.10±0.20(Predicted)
form 
Crystalline Powder, Crystals and/or Chunks
color 
White to pale yellow to beige
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
InChI
InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3
InChIKey
LZRDHSFPLUWYAX-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(N)CC1
CAS DataBase Reference
87120-72-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38
Safety Statements 
26-36/37/39-22-222636/37/39
RIDADR 
3259
WGK Germany 
2
F 
10-34
Hazard Note 
Irritant
TSCA 
N
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
640042
Product name
4-Amino-1-Boc-piperidine
Purity
97%
Packaging
1g
Price
$42.7
Updated
2024/03/01
Sigma-Aldrich
Product number
640042
Product name
4-Amino-1-Boc-piperidine
Purity
97%
Packaging
5g
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
A2045
Product name
4-Amino-1-tert-butoxycarbonylpiperidine
Purity
>97.0%(T)
Packaging
1g
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
A2045
Product name
4-Amino-1-tert-butoxycarbonylpiperidine
Purity
>97.0%(T)
Packaging
5g
Price
$125
Updated
2024/03/01
Alfa Aesar
Product number
H30779
Product name
4-Amino-1-Boc-piperidine, 97%
Packaging
1g
Price
$53.65
Updated
2024/03/01
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4-Amino-1-Boc-piperidine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

Uses

4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.

Application

4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.

4-Amino-1-Boc-piperidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Di-tert-butyl dicarbonate Sodium Triethylamine Palladium 1,4-Dioxane Tosyl chloride Tetrahydrofuran N-BOC-4-Hydroxypiperidine Dichloromethane Methanol Sodium hydroxide 4,4-Piperidinediol hydrochloride Ammonia

Preparation Products

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4-Amino-1-Boc-piperidine Suppliers

Americas 1 Belgium 1 Canada 2 China 381 Europe 5 France 2 Germany 8 India 45 Italy 1 Japan 2 Switzerland 2 United Kingdom 22 United States 70 Global 542
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View Lastest Price from 4-Amino-1-Boc-piperidine manufacturers

Dorne Chemical Technology co. LTD
Product
4-Amino-1-Boc-piperidine 87120-72-7
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 tons
Release date
2024-03-26
Shandong Hanjiang Chemical Co., Ltd
Product
4-Amino-1-Boc-piperidine 87120-72-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-25
Shanghai Joiny Pharmaceutical Co.,LTD
Product
4-Amino-1-Boc-piperidine 87120-72-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500KG
Release date
2023-03-31

87120-72-7, 4-Amino-1-Boc-piperidineRelated Search:

1-Aminopiperidine 4-Aminoantipyrine Glycine 4-Dimethylaminopyridine DROPERIDOL 4,4'-Diaminodiphenylsulfone Haloperidol 1-Boc-4-Methylaminopiperidine 4-N-BOC-Aminopiperidine ALTRENOGEST N-BOC-3-Aminopiperidine DI-TERT-BUTYL ETHER 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE 1-BOC-3-PIPERIDINECARBOXALDEHYDE N-Boc-4-piperidinemethanol (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid

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  • 4-AMINOPIPERIDINE, 1-BOC PROTECTED
  • 1-Boc-4-piperidine
  • N - bok - 4 - aMino piperidine
  • 4-Amino-1-<i>tert-</i>butoxycarbonylpiperidine
  • 4-Amino-1-Boc-piperidine tert-Butyl 4-Amino-1-piperidinecarboxylate 4-Amino-1-piperidinecarboxylic Acid tert-Butyl Ester
  • 4-AMino-N1-BOC-piperidine
  • 4-AMino-piperidin-1-carboxylic acid tert-butyl ester
  • Tert-butyl 4-aMinopiperidin-1-carboxylate
  • CHEMBRDG-BB 4003509
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  • 4-Amino-piperidine-1-carboxylic acid t-butyl ester
  • tert-butyl 4-aminopiperidine-1-carboxylate(SALTDATA: HCl)
  • tert-Butyl 4-aminopiperidine-1-carboxylate, 4-Amino-1-(tert-butoxycarbonyl)piperidine
  • N-Boc-4-aMino-piperidin
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  • EOS-61525
  • 1-BOC-4-AMI
  • N-BOC-4-amino-piperidine CAS NO.87120-72-7
  • TERT-BUTYL 4-AMINO-1-PIPERIDINECARBOXYLATE
  • N-TERT-BUTOXYCARBONYL-4-AMINOPIPERIDINE
  • N-BOC-4-AMINOPERIDINE
  • N-BOC-4-AMINOPIPERIDINE
  • N-1-BOC-4-AMINOPIPERIDINE
  • N-Boc-4-piperidinamine
  • 1-Butyloxycarbonyl-4-amino-piperidine hydrochloride
  • Boc-Pip(4-NH2)*HCl
  • 4-AMINO-1-BOC-PIPERIDINE, 4-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE >98%
  • 4-AMINO-1-BOC-PIPERIDINE 97%
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  • 4-Aminopiperidine, N1-BOC protected 97%
  • N-BOC-4-PIPERIDINAMINE(4-AMINO-1-BOC-PIPERIDINE )
  • 1-Piperidinecarboxylicacid,4-amino-,1,1-dimethylethylester(9CI)
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  • 1-BOC-4-AMINOPIPERIDINE / 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
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  • t-butyl-4-aminopiperidine-1-carboxylate