2-Bromo-5-fluoropyridine

Product Name: 2-Bromo-5-fluoropyridine
CAS No.: 41404-58-4
Chemical Name: 2-Bromo-5-fluoropyridine
Synonyms: 5-FLUOROPYRIDINE-2-BORONIC ACID;EOS-60511;2-bromo-5-fluoropyr;2-bromo-5-fluoropyridin;2-BoMo-5-fluoropyridine;2-BroMo-5-floropyridine;5-Fluoro-2-broMopyridine;2-BROMO-5-FLUOROPYRIDINE;3-Fluoro-6-bromopyridine;2--5- fluoropyridinebroMide
CBNumber: CB9683345
Molecular Formula: C5H3BrFN
Formula Weight: 175.99
MOL File: 41404-58-4.mol

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2-Bromo-5-fluoropyridine Property

Melting point:: 30-31 °C (lit.)
Boiling point:: 80-83 °C/44 mmHg (lit.)
Density: 1.707±0.06 g/cm3(Predicted)
refractive index: 1.5396
Flash point:: 167 °F
storage temp.: Inert atmosphere,Room Temperature
form: Liquid
pka: -1.63±0.10(Predicted)
color: Colorless to slightly yellow
BRN: 1561456
InChI: InChI=1S/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H
InChIKey: UODINHBLNPPDPD-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(F)C=C1
CAS DataBase Reference: 41404-58-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,F
Risk Statements: 36/37/38-20/21/22-10
Safety Statements: 26-36-16
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595675
Product name: 2-Bromo-5-fluoropyridine
Purity: 97%
Packaging: 5g
Price: $83.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 595675
Product name: 2-Bromo-5-fluoropyridine
Purity: 97%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: B2799
Product name: 2-Bromo-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B2799
Product name: 2-Bromo-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $176
Updated: 2025/07/31

TRC

Product number: F588545
Product name: 3-Fluoro-6-bromopyridine
Packaging: 10g
Price: $195
Updated: 2021/12/16

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2-Bromo-5-fluoropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid

It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Uses

2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.

Synthesis

21717-96-4

41404-58-4

Example C Synthesis of 2-bromo-5-fluoropyridine: 2-Amino-5-fluoropyridine (6.5 g, 58 mmol) was added in batches to 48% hydrobromic acid (28.8 mL, 296 mmol) cooled to 0-5 °C. A solution formed from bromine (8.9 mL, 174 mmol) and sodium nitrite (10 g, 145 mmol) dissolved in 20 mL of water was added slowly and dropwise at 0-5 °C (note: nitrogen release). The reaction mixture was stirred for 1 hour and then quenched with concentrated hydrochloric acid. A 32% sodium hydroxide solution (50.5 mL, 0.55 mol) was then added. The reaction mixture was continued to be stirred for 20 minutes at room temperature and then extracted three times with ether. The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure at 30 °C and 500 mbar (note: the product is volatile). The crude product was purified by rapid chromatography on silica gel with an elution gradient of dichloromethane/pentane (0:100 → 50:50). The final product was 2-bromo-5-fluoropyridine (6.7 g, 66% yield) in light yellow solid form.

References

[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 29
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0268
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 19, p. 5349 - 5352

2-Bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluoropyridine Suppliers

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View Lastest Price from 2-Bromo-5-fluoropyridine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Bromo-5-fluoropyridine 41404-58-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-20

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-5-fluoropyridine 41404-58-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Bromo-5-fluoropyridine 41404-58-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

41404-58-4, 2-Bromo-5-fluoropyridineRelated Search:

1-Hexadecylpyridinium bromide Chromium picolinate Sulfasalazine 2-Bromo-5-chloropyridine 2-Bromopyridine Flupirtine 2-Fluoropyridine 2,6-Lutidine Ethyl bromodifluoroacetate 2-Chloro-3-cyanopyridine 2-Bromo-5-fluoropyrimidine 2-BROMO-5-METHOXYPYRIDINE 2-Bromo-5-methylpyridine 2-Bromo-6-(trifluoromethyl)pyridine 2-Bromo-6-methylpyridine 2-BROMO-5-IODOBENZYL ALCOHOL 2-Bromo-5-nitropyridine 2-Bromo-5-(trifluoromethyl)pyridine

2-BROMO-5-FLUOROPYRIDINE

2--5- fluoropyridinebroMide

2-BroMo-5-fluoropyridine, 97+%

2 - broMine - 5 - fluoride pyridine

5-FLUOROPYRIDIN-2-YL-BORONIC ACID

5-FLUOROPYRIDINE-2-BORONIC ACID

2-bromo-5-fluoropyridin

2-Bromo-5-fluoropyridine98%

5-Fluoro-2-broMopyridine

2-BoMo-5-fluoropyridine

2-BroMo-5-fluoropyridine, 98% 1GR

2-BroMo-5-floropyridine

3-Fluoro-6-bromopyridine

EOS-60511

2-bromo-5-fluoropyr

2-Bromo-5-fluoropyridine &gt

Pyridine, 2-bromo-5-fluoro-

2-Bromo-5-fluoropyridine ISO 9001：2015 REACH

41404-58-4

21404-58-4

41404-58-2

Building Blocks

Bromopyridines

Halopyridines

Fluoropyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Fluorine series

Fluorinated

Organohalides

Bromopyridines

Fluoropyridines

Halopyridines

Boronic Acid

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Variety of halogenated heterocyclic series

Pyridine series

blocks

Bromides

FluoroCompounds

Pyridines

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Fluorin-contained pyridine series

bc0001

41404-58-4