GLYCOPROTEIN, ALPHA1-ACID HUMAN Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: 10 mg/mL, clear, colorless

form 

Lyophilized

biological source

human plasma

Merck 

13,8018

Specific Activity

88-120nmol/min·mg

Safety Information

Hazard Codes 

B

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich

GLYCOPROTEIN, ALPHA1-ACID HUMAN Usage And Synthesis

Chemical Properties

This product is brown or brownish powder, slightly peculiar odor, tasteless. Melting point 120℃. Soluble in water, almost insoluble in methanol, chloroform, benzene, cyclohexane and so on. This product is a kind of proteoglycan, protein content 25%-30%. It has anti-tumor activity both in vivo and in vitro. Its anti-tumor effect is related to its excitation of the body's anti-tumor immune function. Yunzhi polysaccharide can enhance the cellular immune function, and promote the delayed allergic reaction and lymphocyte proliferation reaction. It can also increase the production of interferon, interleukins 1 and 2 and prostaglandins. It can also normalize the low IgG and IgM of the tumor-bearing animals. In addition, it could not enhance the phagocytosis of macrophages in tumor-bearing animals. After oral administration, Yunzhi polysaccharide is absorbed from the digestive tract and distributed to organs and tumor tissues throughout the body, and about 70% of it is eliminated from the body within 24 h. It is mainly excreted in the form of carbon dioxide through the respiratory tract.

Uses

α1-Acid glycoprotein from human plasma has been used:

• as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
• to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
• to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors

Uses

GLYCOPROTEIN, ALPHA1-ACID HUMAN was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine.

General Description

α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family.

Biochem/physiol Actions

α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital.

Purification Methods

Purify the glycoprotein 1 acid by passage through a carboxymethyl cellulose column, then through a Sephadex G-25 column. [Aronson et al. J Biol Chem 243 4564 1968.]

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