GLYCOPROTEIN, ALPHA1-ACID HUMAN Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: 10 mg/mL, clear, colorless

form 

Lyophilized

Merck 

13,8018

Safety Information

Hazard Codes 

B

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

MSDS

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GLYCOPROTEIN, ALPHA1-ACID HUMAN Usage And Synthesis

Uses

α1-Acid glycoprotein from human plasma has been used:

• as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
• to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
• to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors

Uses

GLYCOPROTEIN, ALPHA1-ACID HUMAN was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine.

General Description

α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family.

Biochem/physiol Actions

α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital.

Purification Methods

Purify the glycoprotein 1 acid by passage through a carboxymethyl cellulose column, then through a Sephadex G-25 column. [Aronson et al. J Biol Chem 243 4564 1968.]

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