Potassium bis(trimethylsilyl)amide Chemical Properties

Melting point:

194-195°C

Boiling point:

111 °C

Density 

0.877 g/mL at 25 °C

vapor density 

3.2 (vs air)

vapor pressure 

54 mm Hg ( 25 °C)

refractive index 

1.4920

Flash point:

45 °F

storage temp. 

Refrigerator

solubility 

Miscible with terahydrofuran, ether, benzene and toluene.

form 

Liquid

Specific Gravity

0.877

color 

clear to slightly hazy yellow

Water Solubility 

Reacts with water.

Hydrolytic Sensitivity

8: reacts rapidly with moisture, water, protic solvents

Sensitive 

Moisture Sensitive

BRN 

4006754

CAS DataBase Reference

40949-94-8(CAS DataBase Reference)

EPA Substance Registry System

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8)

Safety Information

Hazard Codes 

C,F,Xn

Risk Statements 

14-34-67-65-63-48/20-11-40-36/37/38-19-37

Safety Statements 

26-36/37/39-45-62-43-46-16-36/37

RIDADR 

UN 3263 8/PG 3

WGK Germany 

3

F 

1-3-10

TSCA 

No

HazardClass 

3

PackingGroup 

II

HS Code 

29319090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Potassium bis(trimethylsilyl)amide Usage And Synthesis

Chemical Properties

Colorless to amber solution

Uses

Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.

Uses

Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.

Uses

Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1

Preparation

Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.

General Description

This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".

Potassium bis(trimethylsilyl)amide(40949-94-8)Related Product Information

• Dichlorodimethylsilane
• TRIMETHYLSILANE
• Potassium sorbate
• tert-Butyldimethylsilyl chloride
• Fomesafen
• RINK AMIDE RESIN
• Azidotrimethylsilane
• Lithium bis(trimethylsilyl)amide
• Hexamethyldisilazane
• Rink Amide Linker
• N-(Trimethylsilyl)acetamide
• Methyltrichlorosilane
• Potassium iodide
• Potassium chloride
• Potassium Citrate
• Hexamethyldisilane
• Tris(hydroxymethyl)aminomethane
• Methyltriethoxysilane