2-Amino-5-methylpyridine

Product Name: 2-Amino-5-methylpyridine
CAS No.: 1603-41-4
Chemical Name: 2-Amino-5-methylpyridine
Synonyms: 5-METHYLPYRIDIN-2-AMINE;NSC 1489;NSC 96444;AKOS 91156;6-amino-3-picolin;2-AMINO-5-PICOLINE;6-AMINO-3-PICOLINE;TIMTEC-BB SBB004353;2-Amino-5-methylpyri;3-Picoline, 6-amino-
CBNumber: CB0485858
Molecular Formula: C6H8N2
Formula Weight: 108.14
MOL File: 1603-41-4.mol

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2-Amino-5-methylpyridine Property

Melting point:: 76-77 °C(lit.)
Boiling point:: 227 °C(lit.)
Density: 227
vapor pressure: 3.706Pa at 25℃
refractive index: 1,524-1,528
Flash point:: 118°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: 1000g/l
form: Crystalline Powder, Crystals or Flakes
pka: pK1: 7.22(+1) (25°C)
color: White to light yellow
Sensitive: Hygroscopic
BRN: 107050
InChIKey: CMBSSVKZOPZBKW-UHFFFAOYSA-N
LogP: 1.08
CAS DataBase Reference: 1603-41-4(CAS DataBase Reference)
NIST Chemistry Reference: 2-Pyridinamine, 5-methyl-(1603-41-4)
EPA Substance Registry System: 6-Amino-3-picoline (1603-41-4)

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Safety

Hazard Codes: T,Xi
Risk Statements: 23/24/25-36/37/38-25
Safety Statements: 26-36/37/39-45-37/39-28A
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TJ5141000
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999
Toxicity: LD50 orl-rat: 200 mg/kg 85JCAE -,841,86

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A75684
Product name: 2-Amino-5-methylpyridine
Purity: 99%
Packaging: 10g
Price: $30.12
Updated: 2024/03/01

Sigma-Aldrich

Product number: A75684
Product name: 2-Amino-5-methylpyridine
Purity: 99%
Packaging: 50g
Price: $58.32
Updated: 2024/03/01

TCI Chemical

Product number: A0732
Product name: 2-Amino-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $46
Updated: 2024/03/01

TCI Chemical

Product number: A0732
Product name: 2-Amino-5-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $489
Updated: 2024/03/01

Alfa Aesar

Product number: A13330
Product name: 2-Amino-5-methylpyridine, 99%
Packaging: 50g
Price: $70.65
Updated: 2024/03/01

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2-Amino-5-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline flakes

Uses

Intermediate.

Uses

2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.

Safety Profile

Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.

Synthesis

2.2 g (0.377 mol) of trimethylamine are condensed at -10 °C. and added at -5 °C. to a solution of 10.03 g (0.092 mol) of 3-methyl-pyridine 1-oxide in 120 ml of methylene chloride. At this temperature, 7.9 (0.11 mol) of thionyl chloride in 15 ml of methylene chloride is added dropwise in 30 minutes. The temperature during this process is kept below 0 °C. The resulting yellow solution is allowed to thaw and is stirred overnight at room temperature. The solvent is removed in vacuo 35 ml of a 48% strength hydrogen bromide solution and then added. The water is distilled off, and the mixture is then heated to 210 °C. A 48% strength hydrogen bromide solution is continuously added dropwise, and water is distilled. After 8 hours, the reaction is completed according to thin-layer chromatography. The mixture is allowed to cool and is adjusted to pH 9 using a dilute sodium hydroxide solution. The mixture is then extracted four times using ethyl acetate. After filtration, the combined extracts are dried over sodium sulphate and concentrated on the rotary evaporator. 8 g (80.5% of theory) of 2-amino-5-methylpyridine are obtained.

Purification Methods

Crystallise it from acetone. [Beilstein 22/9 V 289.]

2-Amino-5-methylpyridine Preparation Products And Raw materials

Raw materials

5-Methylpyridine Trimethylamine 3-Picoline-N-oxide Hydrogen bromide Trimethylamine hydrochloride Chloromethane

Preparation Products

6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID 2-Hydroxy-5-methyl-3-nitropyridine (6-AMINO-3-PYRIDINYL)METHANOL Ethyl 6-aminonicotinate Nalidixic acid 2-AMINO-3-NITRO-5-PICOLINE 6-Fluoronicotinic acid 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID 3-AMINO-2-CHLORO-5-PICOLINE 2-Fluoro-5-methylpyridine TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL]CARBAMATE 6-AMINONICOTINOHYDRAZIDE 6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID (5-METHOXYMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Methyl 6-aminonicotinate METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 2,3-Dichloro-5-(trifluoromethyl)pyridine 2-Amino-3-bromo-5-methylpyridine 2-ACETYLAMINO-3-BROMO-5-METHYLPYRIDINE 2-ACETAMIDO-5-PICOLINE 2-BROMO-3-NITRO-5-METHYL PYRIDINE 2-Chloro-5-methylpyridine 2-Chloro-5-methyl-3-nitropyridine 6-Aminonicotinic acid 2-FLUOROPYRIDINE-5-CARBONYL CHLORIDE METHYL 6-(ACETYLAMINO)NICOTINATE

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2-Amino-5-methylpyridine Suppliers

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View Lastest Price from 2-Amino-5-methylpyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Amino-5-methylpyridine 1603-41-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10 TONS
Release date: 2021-06-24

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Amino-5-methylpyridine 1603-41-4
Price: US $19.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-20

Shanghai Yongzeng Technology Co.,Ltd

Product: 2-Amino-5-methylpyridine 1603-41-4
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-04

1603-41-4, 2-Amino-5-methylpyridineRelated Search:

6-Aminocaproic acid Bensulfuron methyl Methylparaben 2-Chloro-5-chloromethylpyridine Tris(hydroxymethyl)aminomethane 2-Aminopyridine 2,5-Dimethylpyridine Methyl salicylate 2-Amino-4,6-dimethylpyridine METSULFURON METHYL 4-Aminopyridine Dibenzylamine 3-Aminopyridine Triethanolamine Methyl acetate DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Kresoxim-methyl Bis(2-ethylhexyl)amine

5-Methyl-2-aminopyridine

5-methyl-2-pyridinamin

5-Methyl-2-pyridinamine

5-Methyl-2-pyridylamine dine

6-Amino-3-picoline 2-Amino-5-picoline 5-Methyl-2-pyridylamine

6-Amino-3-picoline, 5-Methylpyridin-2-amine

2-AMino-5-picoline, 99% 10GR

6-amino-3-picolin

Pyridine, 2-amino-5-methyl

2-AMINO-5-METHYLPYRIDINE

NSC 1489

NSC 96444

6-Amino-3-picoline 2-Amino-5-picoline

2-Amino-5-methylpyri

Pirfenidone Impurity 1（Pirfenidone EP Impurity A）

TIMTEC-BB SBB004353

2-Pyridinamine,5-methyl-

3-Picoline, 6-amino-

2-AMINO-5-PICOLINE

5-METHYLPYRIDIN-2-AMINE

5-METHYL-2-PYRIDYLAMINE

6-AMINO-3-PICOLINE

6-AMINO-BETA-PICOLINE

AKOS 91156

2-AMINO-5-METHYLPYRIDINE 98%

2-AMINO-5-METHYLPYRIDINE, PHARMA

2-Amino-5-picoline;2-Amino-5-methylpyridine; 5-Methylpyridin-2-amine

2-Pyridinamine,5-methyl-(9CI)

2-AMINO-5-METHYLPYRIDINE (2-AMINO-5-PICOLINE)

2-AMINO-5-METHYL PYRIDINE 5-METHYLPYRIDIN-2-YLAMINE

2-Amino-5-methylpyridine ,99%

5-Methyl-2(1H)-pyridineimine

2-Amino-5-picoline,99%

2-Amino-5-Picoline(2-Amino-5-MethylPyridine

2-Amio-5-Methylpyridine

Perfenidone Impurity 2

2-Amino-5-methylpyridine &gt

5-Methyl-2-pyridylamin

2-Amino-5-methylpyridine with high quality

Pirfenidone Related Compound A (15 mg) (5-Methylpyridin-2-amine)

2-Amino-5-Methylpyridine 98.5% For Synthesis

Pirfenidone EP Impurity A 5-methylpyridin-2-amine

1603-41-4

1503-41-4

1603-34-1

10603-41-4

504-29-3

Building Blocks

C6

Heterocyclic Building Blocks

Pyridines

Building Blocks

C6

Chemical Synthesis

Heterocyclic Building Blocks

Heterocycle-Pyridine series

amine

Aromatics