Pomalidomide-PEG6-butyl iodide

Product Name: Pomalidomide-PEG6-butyl iodide
CAS No.: 1835705-74-2
Chemical Name: Pomalidomide-PEG6-butyl iodide
Synonyms: Pomalidomide-2-2-2-2-2-2-6-I;Pomalidomide-PEG6-butyl iodide;Pomalidomide-PEG?-butyl iodide;Pomalidomide-PEG₆-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[(21-iodo-3,6,9,12,15-pentaoxaheneicos-1-yl)oxy]-;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-2-2-2-2-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
CBNumber: CB04919986
Molecular Formula: C31H44IN3O11
Formula Weight: 761.6
MOL File: 1835705-74-2.mol

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Pomalidomide-PEG6-butyl iodide Property

Boiling point:: 853.5±65.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 100 mg/mL (131.30 mM; Need ultrasonic)
pka: 10.68±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 903442
Product name: Pomalidomide-PEG6-butyl iodide
Purity: ≥95%
Packaging: 50MG
Price: $521
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1720
Product name: Pomalidomid-PEG6-butyl-I
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

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Pomalidomide-PEG6-butyl iodide Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG₆-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate

IC 50

Cereblon

Pomalidomide-PEG6-butyl iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG6-butyl iodide Suppliers

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View Lastest Price from Pomalidomide-PEG6-butyl iodide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-2-2-2-2-2-2-6-I 1835705-74-2
Price: US $0.00/mg
Min. Order: 100mg
Purity: >95.00%
Supply Ability: 100mg
Release date: 2024-04-01

1835705-74-2, Pomalidomide-PEG6-butyl iodideRelated Search:

E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-CO2H Pomalidomide-PEG2-N3 Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG1-piperazine BI 3663

Pomalidomide-PEG6-butyl iodide

Pomalidomide-2-2-2-2-2-2-6-I

Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[(21-iodo-3,6,9,12,15-pentaoxaheneicos-1-yl)oxy]-

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-2-2-2-2-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Pomalidomide-PEG?-butyl iodide

N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide

Pomalidomide-PEG<sub>6</sub>-butyl iodide

1835705-74-2