Pomalidomide-PEG6-butyl iodide
- Product Name
- Pomalidomide-PEG6-butyl iodide
- CAS No.
- 1835705-74-2
- Chemical Name
- Pomalidomide-PEG6-butyl iodide
- Synonyms
- Pomalidomide-2-2-2-2-2-2-6-I;Pomalidomide-PEG6-butyl iodide;Pomalidomide-PEG?-butyl iodide;Acetamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-[(21-iodo-3,6,9,12,15-pentaoxaheneicos-1-yl)oxy]-;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-24-iodo-3,6,9,12,15,18-hexaoxatetracosanamide, Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-2-2-2-2-2-2-6-I, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber
- CB04919986
- Molecular Formula
- C31H44IN3O11
- Formula Weight
- 761.6
- MOL File
- 1835705-74-2.mol
Pomalidomide-PEG6-butyl iodide Property
- Boiling point:
- 853.5±65.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 100 mg/mL (131.30 mM; Need ultrasonic)
- pka
- 10.68±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- 903442
- Product name
- Pomalidomide-PEG6-butyl iodide
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $531
- Updated
- 2023/06/20
- Product number
- PTC1720
- Product name
- Pomalidomid-PEG6-butyl-I
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
Pomalidomide-PEG6-butyl iodide Chemical Properties,Usage,Production
Uses
Protein degrader builiding block Pomalidomide-PEG6-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG6-butyl iodide Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG6-butyl iodide Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58
View Lastest Price from Pomalidomide-PEG6-butyl iodide manufacturers
- Product
- Pomalidomide-2-2-2-2-2-2-6-I 1835705-74-2
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01