ChemicalBook > CAS DataBase List > Propargyl-PEG4-thiol
Propargyl-PEG4-thiol
- Product Name
- Propargyl-PEG4-thiol
- CAS No.
- 1347750-80-4
- Chemical Name
- Propargyl-PEG4-thiol
- Synonyms
- SH-PEG4-ALKYNE;HC≡C-CH2-PEG4-SH;CAS_1347750-80-4;ALKYNE-PEG4-THIOL;Propyne-PEG4-thiol;Propargyl-PEG4-thiol;3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
- CBNumber
- CB13155016
- Molecular Formula
- C11H20O4S
- Formula Weight
- 248.3391
- MOL File
- 1347750-80-4.mol
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Propargyl-PEG4-thiol Property
- Boiling point:
- 332.9±37.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 9?+-.0.10(Predicted)
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-23139
- Product name
- Propargyl-PEG4-thiol
- Purity
- 90%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-23139
- Product name
- Propargyl-PEG4-thiol
- Purity
- 90%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-23139
- Product name
- Propargyl-PEG4-thiol
- Purity
- 90%
- Packaging
- 1g
- Price
- $990
- Updated
- 2021/12/16
purepeg
- Product number
- 437904
- Product name
- HC≡C-CH2-PEG4-SH
- Purity
- min.95%
- Packaging
- 250mg
- Price
- $255
- Updated
- 2021/12/16
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Propargyl-PEG4-thiol Chemical Properties,Usage,Production
Description
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
Biological Activity
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
|
Propargyl-PEG4-thiol Preparation Products And Raw materials
Raw materials
Preparation Products
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