PF-6274484
- Product Name
- PF-6274484
- CAS No.
- 1035638-91-5
- Chemical Name
- PF-6274484
- Synonyms
- PF-6274484;PF-6274484 >=98% (HPLC);PF-6274484, 10 mM in DMSO;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor
- CBNumber
- CB14666748
- Molecular Formula
- C18H14ClFN4O2
- Formula Weight
- 372.78
- MOL File
- 1035638-91-5.mol
PF-6274484 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 33 mg/ml; DMSO: 25 mg/ml
- form
- A crystalline solid
- color
- Light yellow to orange
N-Bromosuccinimide Price
- Product number
- 22698
- Product name
- PF-6274484
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 22698
- Product name
- PF-6274484
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 22698
- Product name
- PF-6274484
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- P294153
- Product name
- PF6274484
- Packaging
- 50mg
- Price
- $820
- Updated
- 2021/12/16
- Product number
- 8711DW
- Product name
- N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
- Packaging
- 5mg
- Price
- $209
- Updated
- 2021/12/16
PF-6274484 Chemical Properties,Usage,Production
Description
PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
Uses
PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1].
IC 50
EGFR (WT): 0.18 nM (Ki); EGFRL858R/T790M: 0.14 nM (Ki)
References
[1] Schwartz PA, et al. Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc Natl Acad Sci U S A. 2014;111(1):173-178. DOI:10.1073/pnas.1313733111
PF-6274484 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-6274484 Suppliers
- Tel
- +1-781-999-5354; +17819995354
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- Country
- United States
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