ChemicalBook > CAS DataBase List > POMALIDOMIDE-PEG1-CO2H

POMALIDOMIDE-PEG1-CO2H

Product Name: POMALIDOMIDE-PEG1-CO2H
CAS No.: 2139348-60-8
Chemical Name: POMALIDOMIDE-PEG1-CO2H
Synonyms: 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid;Poma-PEG1-COOH;POMALIDOMIDE-PEG1-CO2H;Pomalidomide-PEG1-COOH;Pomalidomide-PEG1-C2-COOH;Pomalidomide 4'-PEG1-acid;Thalidomide-4-NH-PEG1-COOH;Thalidomide-NH-PEG1-C2-COOH;Pomalidomide-PEG1-CO2H >=95%;Thalidomide-4-NH-PEG1-C2-COOH
CBNumber: CB14743861
Molecular Formula: C18H19N3O7
Formula Weight: 389.36
MOL File: 2139348-60-8.mol

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POMALIDOMIDE-PEG1-CO2H Property

Boiling point:: 726.2±60.0 °C(Predicted)
Density: 1.508±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder or crystals
pka: 4.29±0.10(Predicted)
color: Yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901527
Product name: Pomalidomide-PEG1-CO2H
Purity: ≥95%
Packaging: 50MG
Price: $560
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1150
Product name: Pomalidomide-PEG1-COOH
Packaging: 50mg
Price: $702
Updated: 2021/12/16

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POMALIDOMIDE-PEG1-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG₁-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

IC 50

Cereblon

storage

Store at -20°C

POMALIDOMIDE-PEG1-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-PEG1-CO2H Suppliers

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View Lastest Price from POMALIDOMIDE-PEG1-CO2H manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: POMALIDOMIDE-PEG1-CO2H 2139348-60-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-PEG1-COOH 2139348-60-8
Price: US $0.00/mg
Min. Order: 250mg
Purity: >99.00%
Supply Ability: 250mg
Release date: 2024-04-01

2139348-60-8, POMALIDOMIDE-PEG1-CO2HRelated Search:

Pomalidomide-PEG4-CO2H Pomalidomide-PEG3-CO2H POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-Amine HCl salt E3 Ligase Ligand-Linker Conjugates 1 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 POMALIDOMIDE-PEG1-ALKYNE

POMALIDOMIDE-PEG1-CO2H

Pomalidomide-PEG1-CO2H >=95%

Pomalidomide-PEG1-COOH

Pomalidomide-PEG1-C2-COOH

3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid

Thalidomide-4-NH-PEG1-COOH

Thalidomide-NH-PEG1-C2-COOH

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-

3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

Thalidomide-4-NH-PEG1-C2-COOH

Poma-PEG1-COOH

Pomalidomide 4'-PEG1-acid

3-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]propanoic Acid

3-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)propanoic acid

Pomalidomide-PEG<sub>1</sub>-CO<sub>2</sub>H

2139348-60-8

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