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POMALIDOMIDE-PEG1-CO2H

Product Name
POMALIDOMIDE-PEG1-CO2H
CAS No.
2139348-60-8
Chemical Name
POMALIDOMIDE-PEG1-CO2H
Synonyms
3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid;Poma-PEG1-COOH;POMALIDOMIDE-PEG1-CO2H;Pomalidomide-PEG1-COOH;Pomalidomide-PEG1-C2-COOH;Pomalidomide 4'-PEG1-acid;Thalidomide-4-NH-PEG1-COOH;Thalidomide-NH-PEG1-C2-COOH;Pomalidomide-PEG1-CO2H >=95%;Thalidomide-4-NH-PEG1-C2-COOH
CBNumber
CB14743861
Molecular Formula
C18H19N3O7
Formula Weight
389.36
MOL File
2139348-60-8.mol
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POMALIDOMIDE-PEG1-CO2H Property

Boiling point:
726.2±60.0 °C(Predicted)
Density 
1.508±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder or crystals
pka
4.29±0.10(Predicted)
color 
Yellow to brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901527
Product name
Pomalidomide-PEG1-CO2H
Purity
≥95%
Packaging
50MG
Price
$1050
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1150
Product name
Pomalidomide-PEG1-COOH
Packaging
50mg
Price
$702
Updated
2021/12/16
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POMALIDOMIDE-PEG1-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

POMALIDOMIDE-PEG1-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-PEG1-CO2H Suppliers

China 39 India 1 Japan 1 United States 1 Global 42
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7182
Advantage
65
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Borenpharm Co., Ltd
Tel
027-65563561
Fax
86-27-59218822
Email
sales@borenpharm.com
Country
China
ProdList
1245
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9945
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1385
Advantage
58
CR Corporation Limited
Tel
+8613062833949
Email
fred.wen@crcorporation.cn
Country
China
ProdList
8647
Advantage
58
Wuhan Borenpharm Co., Ltd
Tel
027-65563561 18717150066
Fax
027-59218822
Email
3207347307@qq.com
Country
CHINA
ProdList
1238
Advantage
58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2351
Advantage
58
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View Lastest Price from POMALIDOMIDE-PEG1-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-PEG1-COOH 2139348-60-8
Price
US $0.00/mg
Min. Order
250mg
Purity
>99.00%
Supply Ability
250mg
Release date
2024-04-01

2139348-60-8, POMALIDOMIDE-PEG1-CO2HRelated Search:

Pomalidomide-PEG4-CO2H Pomalidomide-PEG3-CO2H POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2 Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-Amine HCl salt E3 Ligase Ligand-Linker Conjugates 1 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 POMALIDOMIDE-PEG1-ALKYNE

  • POMALIDOMIDE-PEG1-CO2H
  • Pomalidomide-PEG1-CO2H >=95%
  • Pomalidomide-PEG1-COOH
  • Pomalidomide-PEG1-C2-COOH
  • 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid
  • Thalidomide-4-NH-PEG1-COOH
  • Thalidomide-NH-PEG1-C2-COOH
  • Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-
  • 3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Thalidomide-4-NH-PEG1-C2-COOH
  • Poma-PEG1-COOH
  • Pomalidomide 4'-PEG1-acid
  • 3-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]propanoic Acid
  • 3-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)propanoic acid
  • 2139348-60-8
  • peg