ChemicalBook > CAS DataBase List > HC TOXIN

HC TOXIN

Product Name
HC TOXIN
CAS No.
83209-65-8
Chemical Name
HC TOXIN
Synonyms
Toxin I;HC TOXIN;HC toxin I;Cyclo(aoe-Pro-Ala-ala);HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;HC Toxin, histone deacetylase (HDAC) inhibitor;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID);Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-];Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
CBNumber
CB2460604
Molecular Formula
C21H32N4O6
Formula Weight
436.51
MOL File
83209-65-8.mol
More
Less

HC TOXIN Property

Boiling point:
819.2±65.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 10 mg/ml; Methanol: 10 mg/ml
form 
lyophilized powder
pka
13.33±0.70(Predicted)
color 
Off-white to light yellow
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H7270
Product name
HC toxin from Helminthosporium carbonum
Purity
lyophilized powder
Packaging
5mg
Price
$767
Updated
2022/05/15
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
500μg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
1mg
Price
$165
Updated
2024/03/01
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
5mg
Price
$721
Updated
2024/03/01
TRC
Product number
H115005
Product name
HCToxin
Packaging
5mg
Price
$1540
Updated
2021/12/16
More
Less

HC TOXIN Chemical Properties,Usage,Production

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Uses

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

HC TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

HC TOXIN Suppliers

China 51 Switzerland 2 United States 9 USA 1 Global 63
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77

83209-65-8, HC TOXINRelated Search:

Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN CAY10603 OXAMFLATIN Tubacin Entinostat M344 Parthenolide HC TOXIN Cyclen N-OCTYL PYRROLIDINE Acetamide, N-(2-(nonylamino)ethyl)-

  • HC TOXIN FROM HELMINTHOSPORIUM CARBONUM
  • Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
  • Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
  • HC toxin I
  • Toxin I
  • Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
  • Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
  • Cyclo(aoe-Pro-Ala-ala)
  • Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)
  • Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-
  • (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)
  • HC TOXIN
  • HC Toxin, histone deacetylase (HDAC) inhibitor
  • 83209-65-8
  • C21H32N4O6
  • Cell Signaling and Neuroscience
  • Mold
  • Toxins and Venoms