POMALIDOMIDE-PEG2-CO2H

ChemicalBook > CAS DataBase List > POMALIDOMIDE-PEG2-CO2H

Product Name: POMALIDOMIDE-PEG2-CO2H
CAS No.: 2140807-17-4
Chemical Name: POMALIDOMIDE-PEG2-CO2H
Synonyms: NUN 07174;Poma-PEG2-COOH;Pomalidomide-PEG2-COOH;POMALIDOMIDE-PEG2-CO2H;Pomalidomide-PEG2-Acid;Pomalidomide 4'-PEG2-acid;Thalidomide-4-NH-PEG2-COOH;Thalidomide-NH-PEG2-C2-COOH;Pomalidomide-PEG2-CO2H >=98%;Thalidomide-4-NH-PEG2-C2-COOH
CBNumber: CB44744117
Molecular Formula: C20H23N3O8
Formula Weight: 433.41
MOL File: 2140807-17-4.mol

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POMALIDOMIDE-PEG2-CO2H Property

Boiling point:: 744.6±60.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder or crystals
pka: 4.28±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901526
Product name: Pomalidomide-PEG2-CO2H
Purity: 95%
Packaging: 50MG
Price: $1070
Updated: 2023/06/20

Iris Biotech GmbH

Product number: PTC1160
Product name: Pomalidomide-PEG2-COOH
Packaging: 50mg
Price: $702
Updated: 2021/12/16

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POMALIDOMIDE-PEG2-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG₂-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

storage

Store at -20°C

POMALIDOMIDE-PEG2-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-PEG2-CO2H Suppliers

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View Lastest Price from POMALIDOMIDE-PEG2-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-PEG2-COOH 2140807-17-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

2140807-17-4, POMALIDOMIDE-PEG2-CO2HRelated Search:

Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG2-N3 Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG3-CO2H E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-NH2 POMALIDOMIDE-PEG2-ALKYNE

POMALIDOMIDE-PEG2-CO2H

Pomalidomide-PEG2-COOH

Pomalidomide-PEG2-CO2H >=98%

NUN 07174

Thalidomide-4-NH-PEG2-COOH

Thalidomide-NH-PEG2-C2-COOH

Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-

3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid

Thalidomide-4-NH-PEG2-C2-COOH

3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic Acid

Poma-PEG2-COOH

Pomalidomide-PEG2-Acid

3-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]propanoic acid

Pomalidomide 4'-PEG2-acid

2140807-17-4

APIs

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