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POMALIDOMIDE-PEG2-CO2H

Product Name
POMALIDOMIDE-PEG2-CO2H
CAS No.
2140807-17-4
Chemical Name
POMALIDOMIDE-PEG2-CO2H
Synonyms
NUN 07174;Poma-PEG2-COOH;Pomalidomide-PEG2-COOH;POMALIDOMIDE-PEG2-CO2H;Pomalidomide-PEG2-Acid;Thalidomide-4-NH-PEG2-COOH;Thalidomide-NH-PEG2-C2-COOH;Pomalidomide-PEG2-CO2H >=98%;Thalidomide-4-NH-PEG2-C2-COOH;3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid
CBNumber
CB44744117
Molecular Formula
C20H23N3O8
Formula Weight
433.41
MOL File
2140807-17-4.mol
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POMALIDOMIDE-PEG2-CO2H Property

Boiling point:
744.6±60.0 °C(Predicted)
Density 
1.456±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder or crystals
pka
4.28±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901526
Product name
Pomalidomide-PEG2-CO2H
Purity
95%
Packaging
50MG
Price
$1070
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1160
Product name
Pomalidomide-PEG2-COOH
Packaging
50mg
Price
$702
Updated
2021/12/16
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POMALIDOMIDE-PEG2-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

POMALIDOMIDE-PEG2-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-PEG2-CO2H Suppliers

China 32 Japan 1 United States 1 Global 34
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View Lastest Price from POMALIDOMIDE-PEG2-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-PEG2-COOH 2140807-17-4
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
100mg
Release date
2024-04-01

2140807-17-4, POMALIDOMIDE-PEG2-CO2HRelated Search:

Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG2-N3 Pomalidomide-PEG4-azide Pomalidomide-PEG2-butyl iodide E3 Ligase Ligand-Linker Conjugates 22 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG4-CO2H E3 Ligase Ligand-Linker Conjugates 1 Pomalidomide-PEG1-azide Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG1-CO2H Pomalidomide-O-C4-NH2 Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG3-CO2H E3 ligase Ligand-Linker Conjugates 50 Pomalidomide-PEG3-NH2 POMALIDOMIDE-PEG2-ALKYNE

  • POMALIDOMIDE-PEG2-CO2H
  • Pomalidomide-PEG2-COOH
  • Pomalidomide-PEG2-CO2H >=98%
  • NUN 07174
  • Thalidomide-4-NH-PEG2-COOH
  • Thalidomide-NH-PEG2-C2-COOH
  • Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid
  • Thalidomide-4-NH-PEG2-C2-COOH
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic Acid
  • Poma-PEG2-COOH
  • Pomalidomide-PEG2-Acid
  • 2140807-17-4
  • APIs
  • peg