ChemicalBook > CAS DataBase List > 1-Methylpiperazine

1-Methylpiperazine

Product Name
1-Methylpiperazine
CAS No.
109-01-3
Chemical Name
1-Methylpiperazine
Synonyms
N-METHYLPIPERAZINE;methylpiperazine;NMPRZ;4-Methylpiperazine;N-Methylpiperazin;Piperazine,1-methyl-;CL046;AKOS BBS-00003665;1-methyl-piperazin;METHYLPIPERAZINE-N
CBNumber
CB4478526
Molecular Formula
C5H12N2
Formula Weight
100.16
MOL File
109-01-3.mol
More
Less

1-Methylpiperazine Property

Melting point:
-6 °C
Boiling point:
138 °C(lit.)
Density 
0.903 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
12 hPa (20 °C)
refractive index 
n20/D 1.466(lit.)
Flash point:
108 °F
storage temp. 
2-8°C
solubility 
Chloroform (Soluble), Methanol (Soluble)
pka
pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form 
Liquid
Specific Gravity
0.903
color 
Clear
PH
11-12 (50g/l, H2O, 20℃)
explosive limit
1.2-9.9%(V)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
102724
InChIKey
PVOAHINGSUIXLS-UHFFFAOYSA-N
LogP
-0.57 at 25℃
CAS DataBase Reference
109-01-3(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-methyl-(109-01-3)
EPA Substance Registry System
Piperazine, 1-methyl- (109-01-3)
More
Less

Safety

Hazard Codes 
T,F,C,Xi
Risk Statements 
10-21-23-34-36/37/38-20/21
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 2734 8/PG 2
WGK Germany 
2
RTECS 
TM1225000
Autoignition Temperature
320 °C
Hazard Note 
Flammable/Toxic/Corrosive/Store under nitrogen
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
5ml
Price
$35
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1118
Product name
1-Methylpiperazine
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
15MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05859
Product name
1-Methylpiperazine
Purity
for synthesis
Packaging
250ML
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
130001
Product name
1-Methylpiperazine
Purity
99%
Packaging
5g
Price
$36.5
Updated
2024/03/01
Sigma-Aldrich
Product number
14549
Product name
1-Methylpiperazine
Purity
analytical standard
Packaging
5ml
Price
$70.8
Updated
2024/03/01
More
Less

1-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

1-Methylpiperazine Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE PIPERAZINE HEXAHYDRATE Carbon dioxide Piperazine Methanol

Preparation Products

AZIMILIDE 3-(4-Methylpiperazin-1-yl)aniline 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 1-Amino-4-methylpiperazine Zopiclone 1-METHYLPIPERAZINE DIHYDROCHLORIDE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 3-(4-Methylpiperazin-1-ylmethyl)benzoic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile Chlorcyclizine hydrochloride Levofloxacin (3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one CHLORCYCLIZINE 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine 1-AdaMantanethylaMine 1-FORMYL-4-METHYLPIPERAZINE 4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Clozapine 1-METHYL-4-(3-NITROPHENYL)PIPERAZINE 4-[(4-Methylpiperazin-1-yl)methyl]aniline 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 4-(4-Methylpiperazino)aniline 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 1-methyl-4-nitrosopiperazine
More
Less

1-Methylpiperazine Suppliers

Americas 1 Belgium 4 Canada 7 China 523 Europe 5 France 2 Germany 13 India 86 Japan 11 Poland 1 Russia 1 Singapore 1 Slovakia 1 South Korea 3 Spain 1 Switzerland 6 The Netherlands 2 Ukraine 2 United Kingdom 21 United States 81 Global 772
LEHVOSS UK / Gee Lawson Chemical Division
Tel
--
Fax
--
Email
david.davies@lehvoss.co.uk
Country
United Kingdom
ProdList
892
Advantage
58
R.W. Unwin & Co. Ltd
Tel
--
Fax
--
Email
sales@rwunwin.co.uk
Country
United Kingdom
ProdList
238
Advantage
58
Discovery Fine Chemicals Ltd.
Tel
--
Fax
--
Email
info@discofinechem.com
Country
United Kingdom
ProdList
530
Advantage
58
Cenik Chemicals
Tel
--
Fax
--
Email
lo@cenikchemicals.com
Country
United Kingdom
ProdList
1681
Advantage
58
Molekula Limited
Tel
--
Fax
--
Email
o@molekula.com
Country
United Kingdom
ProdList
6127
Advantage
58
Apollo Scientific Ltd
Tel
--
Fax
--
Email
ales@apo
Country
United Kingdom
ProdList
4521
Advantage
58
Manchester Organics
Tel
--
Fax
--
Email
info@manchesterorganics.com
Country
United Kingdom
ProdList
6834
Advantage
67
Biosynth Carbosynth
Tel
--
Fax
--
Email
ales@carbosynth.com
Country
United Kingdom
ProdList
2598
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Molekula Ltd
Tel
--
Fax
--
Email
info@molekula.com
Country
United Kingdom
ProdList
4060
Advantage
50
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
Whyte Chemicals
Tel
--
Fax
--
Email
sales@whytechemicals.co.uk
Country
United Kingdom
ProdList
3748
Advantage
50
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
Hawks Scientific Ltd
Tel
--
Fax
--
Email
pete@hawks-scientific.com
Country
United Kingdom
ProdList
2221
Advantage
43
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
MDA Chemicals Ltd.
Tel
--
Fax
--
Email
sheila@mda-chem.co.uk
Country
United Kingdom
ProdList
1961
Advantage
30
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
Eurolabs Limited
Tel
--
Fax
--
Country
United Kingdom
ProdList
6309
Advantage
46
More
Less

View Lastest Price from 1-Methylpiperazine manufacturers

Sinoway Industrial co., ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2023-10-19
Hebei Weibang Biotechnology Co., Ltd
Product
1-Methylpiperazine 109-01-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Hebei Yanxi Chemical Co., Ltd.
Product
1-Methylpiperazine 109-01-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-18

109-01-3, 1-MethylpiperazineRelated Search:

1,2-Dimethylhydrazine Dihydrochloride METSULFURON METHYL 1-(2-Hydroxyethyl)piperazine 4-Methylmorpholine N-oxide N-Methylpiperidine N-Aminoethylpiperazine N-Methyl-2-pyrrolidone 1-Methylpyrrolidine Thiophanate-methyl 1-Methylimidazole Piperacillin Methyl acetate Piperazine Tribenuron methyl Kresoxim-methyl Methyl salicylate Methyl 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide

  • N-METHYLPIPERAZINE
  • NMPRZ
  • 1-methyl-piperazin
  • 1-METHYLPIPERAZINE FOR SYNTHESIS
  • Cyclizine Related CoMpound A
  • <i>N</i>-Methyl piperazine
  • 4-Methylpiperazine
  • 1-Methylpiperazine, 99+% 100GR
  • 1-Methylpiperazine, 99+% 500GR
  • 1-Methylpiperazine, 99+% 5GR
  • Olanzapine Impurity 15
  • CL046
  • 1-Methylpiperazine / N-Methylpiperazine
  • Piperazine,1-methyl-
  • LABOTEST-BB LTBB000517
  • methylpiperazine
  • METHYLPIPERAZINE-N
  • 1-METHYLPIPERAZINE
  • AKOS BBS-00003665
  • 1-METHYLPIPERAZINE, STANDARD FOR GC
  • N-MethylPiperazineForSynthesis
  • N-EthylPiperazineForSynthesis
  • N-Methylpiperazine, 98+%
  • 1-Methylpiperazine, 99+%
  • N-Methylpiperazin
  • n-METHYL PIPERAZINE extrapure
  • 1-Methylpiperazine, 98+%
  • 1-Methylpiperazine&gt
  • Cyclizine impurity A CRS
  • Diethylcarbamazine EP Impurity A
  • Imatinib EP Impurity G
  • N-Methylpiperazini
  • N-METHYL PIPERASINE
  • 1-Methylpiperazine ISO 9001：2015 REACH
  • Cyclizine impurity A (Y0000886)
  • 1-Methylpiperazine extrapure, 99%
  • Cyclizine Related Compound A (1-methylpiperazine) (1154015)
  • Cyclizine USP Related Compound A
  • Imatinib Mesilate EP Impurity G
  • Imatinib Impurity 54
  • Cyclizine Hydrochloride Impurity A
  • Imatinib Mesilate Impurity G
  • Chlorcyclizine EP Impurity A
  • 4-((3-carboxy-2-hydroxynaphthalen-1-yl)methyl)-3-hydroxy-7-methyl-2-naphthoic acid
  • N-Methyl Piperazine 99% For Synthesis
  • N-Methyl Peprazine
  • 1-Methyipiperazine
  • 109-01-3
  • 1109-01-3
  • 468-79-0
  • 203-639-5
  • NC4H8NCH3
  • AMINE
  • Building Blocks
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • Piperazines