ChemicalBook > CAS DataBase List > 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

Product Name
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
CAS No.
1144035-53-9
Chemical Name
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
Synonyms
CS-894;PF 8380;PF-8380 HCL;PF 8380; PF8380;PF-8380, ATX Inhibitor;PF-8380;PF 8380;PF8380;Autotaxin Inhibitor III, PF-8380;Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-ca.;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carbo
CBNumber
CB52589638
Molecular Formula
C22H21Cl2N3O5
Formula Weight
478.33
MOL File
1144035-53-9.mol
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4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Property

Density 
1.419
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
Tan powder
pka
8.74±0.70(Predicted)
color 
white to beige
InChIKey
JMSUDQYHPSNBSN-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0715
Product name
PF-8380
Purity
≥98% (HPLC)
Packaging
5mg
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
189512
Product name
Autotaxin Inhibitor III, PF-8380
Packaging
10mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
12018
Product name
PF-8380
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
12018
Product name
PF-8380
Purity
≥95%
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0715
Product name
PF-8380
Purity
≥98% (HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
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4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Chemical Properties,Usage,Production

Uses

PF-8380 has been used in biological assays. It has also been used to estimate the role of intestinally-derived lysophosphatidic acid in dyslipidemia and atherosclerosis.

Uses

PF8380 is a novel autotaxin inhibitor which reduces lysophosphatidic acid levels in plasma and at the site of inflammation.

General Description

An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30 mg/kg, p.o.).

Biological Activity

pf-8380 is a specific and potent inhibitor of autotaxin (atx) with an ic50 value of 2.8 nm [1].autotaxin (atx) is a secreted enzyme having lysophospholipase d activity

Biochem/physiol Actions

PF-8380 [6-(3-(piperazin-1-yl)propanoyl)benzo[d]oxazol-2(3H)-one] has the ability to change the resistant and invasive features of glioblastoma and helps to improve the response to radiation therapy.

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Suppliers

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View Lastest Price from 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester manufacturers

Career Henan Chemical Co
Product
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester 1144035-53-9
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

1144035-53-9, 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl esterRelated Search:

FGF-401 BEZ235 (NVP-BEZ235, Dactolisib) PT-2385 PF-3450074 PF-562271 PF 573228 PF-9366 PI-3065 PF-3758309 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF-04979064

  • PF 8380
  • 3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate
  • 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
  • PF-8380 HCL
  • Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem
  • PF 8380; PF8380
  • CS-894
  • 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxyl
  • PF-8380, ATX Inhibitor
  • 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-ca.
  • 3,5-dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-2-carboxylate
  • 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic acid (3,5-dichlorophenyl)methyl ester
  • 3,5-dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylate
  • PF-8380;PF 8380;PF8380
  • 3,5-Dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]-1-piperazinecarboxylate
  • 3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carbo
  • Autotaxin Inhibitor III, PF-8380
  • 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester
  • (3,5-dichlorophenyl)methyl4-(3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl)piperazine-1-carboxylate
  • 1144035-53-9