PF-06447475

Product Name: PF-06447475
CAS No.: 1527473-33-1
Chemical Name: PF-06447475
Synonyms: CS-1734;PF-06447475;PF-06447475, >98%;PF 06447475;PF06447475;3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile;Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
CBNumber: CB52735532
Molecular Formula: C17H15N5O
Formula Weight: 305.33
MOL File: 1527473-33-1.mol

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PF-06447475 Property

Melting point:: >223°C (dec.)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble10mg/mL, clear
pka: 12.96±0.50(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18375
Product name: PF-06447475
Purity: ≥98%
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Cayman Chemical

Product number: 18375
Product name: PF-06447475
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 18375
Product name: PF-06447475
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2021/12/16

Cayman Chemical

Product number: 18375
Product name: PF-06447475
Purity: ≥98%
Packaging: 25mg
Price: $313
Updated: 2021/12/16

Usbiological

Product number: 462312
Product name: PF 06447475
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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PF-06447475 Chemical Properties,Usage,Production

Uses

PF 06447475 is a highly potent LRRK2 kinase inhibitor. Highly selective, and mobile, it is used in the treatment of Parkinson’s disease which has been linked to Leucine rich repeat kinase 2 (LRRK2) enzymes.

Enzyme inhibitor

This potent, brain penetrant and selective LRRK2 inhibitor (FW = 305.44 g/mol; CAS 1527473-33-1), also named 3-[4-(4-morpholinyl)-7Hpyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, targets Leucine-Rich Repeat Kinase 2, IC50 = 3 nM, (encoded by the PARK8 gene), which phosphorylates Akt1 (Ser-473), suggesting that Akt1 is a convincing candidate for the physiological substrate of LRRK2. Diseaseassociated mutations forms of LRRK2 (including Arg-1441-Cys, Gly-2019- Ser, and Ile-2020-Thr) exhibit reduced interaction with, and phosphorylation of, Akt1, a finding that suggests a possible mechanism for the neurodegeneration caused by LRRK2 mutations. Therapeutic approaches to slow or block the progression of Parkinson disease (PD) do not exist. Given that genetic and biochemical studies implicate α-synuclein and leucine-rich repeat kinase 2 (LRRK2) in late-onset PD. In wild-type rats as well as transgenic [Gly-2019-Ser]-LRRK2 rats that were injected intracranially with adeno-associated viral vectors expressing human α- synuclein in the substantia nigra, those expressing [Gly-2019-Ser]-LRRK2 show exacerbated dopaminergic neurodegeneration and inflammation in response to the overexpression of α-synuclein. Both neurodegeneration and neuroinflammation associated with [Gly-2019-Ser]-LRRK2 expression were mitigated by PF-06447475, which provided neuroprotection in wildtype rats. There are no adverse pathological indications in the lung, kidney, or liver of rats treated with PF-06447475. Pharmacological inhibition of LRRK2 is well tolerated for a 4-week period of time in rats and can counteract dopaminergic neurodegeneration caused by acute α-synuclein overexpression

PF-06447475 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06447475 Suppliers

China 82 India 1 United Kingdom 1 United States 14 Global 98

Target molecule Corp.

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View Lastest Price from PF-06447475 manufacturers

Career Henan Chemical Co

Product: PF-06447475 1527473-33-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 20kg
Release date: 2019-09-05

1527473-33-1, PF-06447475Related Search:

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF-06700841 tosylate PF-06650833 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

PF-06447475

3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile

3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

PF 06447475;PF06447475

CS-1734

PF-06447475, >98%

Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-

1527473-33-1

Inhibitors