2-CHLORO-4-METHOXYPYRIMIDINE
- Product Name
- 2-CHLORO-4-METHOXYPYRIMIDINE
- CAS No.
- 22536-63-6
- Chemical Name
- 2-CHLORO-4-METHOXYPYRIMIDINE
- Synonyms
- 2-chloro-4-methoxy pyrimdine;2-Chloro-6-methoxypyrimidine;2-CHLORO-4-METHOXYPYRIMIDINE;2-Chloro-4-methoxy-1,2-diazine;Pyrimidine, 2-chloro-4-methoxy-;2-Chloro-4-methoxypyrimidine 98%;Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI);2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB5304318
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 22536-63-6.mol
2-CHLORO-4-METHOXYPYRIMIDINE Property
- Melting point:
- 54-57 °C (lit.)
- Boiling point:
- 96-97 °C(Press: 18 Torr)
- Density
- 1.292±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 0.07±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to yellow
- InChIKey
- BDXYNMVQMBCTDB-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 536458
- Product name
- 2-Chloro-4-methoxypyrimidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $30
- Updated
- 2023/06/20
- Product number
- 536458
- Product name
- 2-Chloro-4-methoxypyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $59.9
- Updated
- 2023/06/20
- Product number
- C367688
- Product name
- 2-Chloro-4-methoxypyrimidine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR46001
- Product name
- 2-Chloro-4-methoxypyrimidine
- Packaging
- 100g
- Price
- $849
- Updated
- 2021/12/16
- Product number
- HCH0019214
- Product name
- 2-CHLORO-4-METHOXYPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $852.21
- Updated
- 2021/12/16
2-CHLORO-4-METHOXYPYRIMIDINE Chemical Properties,Usage,Production
Uses
2-Chloro-4-methoxypyrimidine is a pharmaceutical intermediate compound used in the preparation of Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of Human Immunodeficiency Virus (HIV) infections, which prevents the replication of the virus.
Synthesis
2-Chloro-4-methoxypyrimidine is prepared by the reaction of 2,4-Dichloropyrimidine and Sodium Methoxide. The specific synthesis steps are as follows:
To a solution of 2,4-dichloropyrimidine (41.8 g, 280 mmol) in methanol (900 mL)was added a solution of CH3ONa (15.2 g, 280 mmol) in 100 mL methanol at 0 °C. The mixturewas stirred at rt for overnight. The mixture was concentrated under reduce pressure to give awhite solid, which was diluted with water (400mL) and extracted with ethyl acetate (500 mL x3). The combined organic layer was washed with brine, dried, concentrated to give 2-chloro-4-methoxypyrimidine (40 g, yield: 98percent) as white solid. ESI-MS (M+H): 145.0. ‘H NMR (400 MHz, CDC13) (5: 8.30 (d, J= 5.6 Hz ,1H), 6.68 (s, J= 5.6 Hz ,1H), 4.02 (s, 3H).
2-CHLORO-4-METHOXYPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-4-METHOXYPYRIMIDINE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
- Advantage
- 58
- Tel
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- Fax
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- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
- 67
- Tel
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- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
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- Fax
- --
- info@atlantic-chemicals.com
- Country
- United Kingdom
- ProdList
- 5618
- Advantage
- 63
View Lastest Price from 2-CHLORO-4-METHOXYPYRIMIDINE manufacturers
- Product
- 2-Chloro-4-MethoxypyriMidine 22536-63-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-12
- Product
- 2-Chloro-4-MethoxypyriMidine 22536-63-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2-CHLORO-4-METHOXYPYRIMIDINE 22536-63-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-19