2-CHLORO-4-METHOXYPYRIMIDINE

Product Name: 2-CHLORO-4-METHOXYPYRIMIDINE
CAS No.: 22536-63-6
Chemical Name: 2-CHLORO-4-METHOXYPYRIMIDINE
Synonyms: 2-chloro-4-methoxy pyrimdine;2-Chloro-6-methoxypyrimidine;2-CHLORO-4-METHOXYPYRIMIDINE;2-Chloro-4-methoxy-1,2-diazine;Pyrimidine, 2-chloro-4-methoxy-;2-Chloro-4-methoxypyrimidine 98%;Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI);2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB5304318
Molecular Formula: C5H5ClN2O
Formula Weight: 144.56
MOL File: 22536-63-6.mol

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2-CHLORO-4-METHOXYPYRIMIDINE Property

Melting point:: 54-57 °C (lit.)
Boiling point:: 96-97 °C(Press: 18 Torr)
Density: 1.292±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 0.07±0.20(Predicted)
form: Crystalline Powder
color: White to yellow
InChIKey: BDXYNMVQMBCTDB-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 536458
Product name: 2-Chloro-4-methoxypyrimidine
Purity: 98%
Packaging: 1g
Price: $30
Updated: 2023/06/20

Sigma-Aldrich

Product number: 536458
Product name: 2-Chloro-4-methoxypyrimidine
Purity: 98%
Packaging: 5g
Price: $59.9
Updated: 2023/06/20

TRC

Product number: C367688
Product name: 2-Chloro-4-methoxypyrimidine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR46001
Product name: 2-Chloro-4-methoxypyrimidine
Packaging: 100g
Price: $849
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0019214
Product name: 2-CHLORO-4-METHOXYPYRIMIDINE
Purity: 95.00%
Packaging: 2.5G
Price: $852.21
Updated: 2021/12/16

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2-CHLORO-4-METHOXYPYRIMIDINE Chemical Properties,Usage,Production

Uses

2-Chloro-4-methoxypyrimidine is a pharmaceutical intermediate compound used in the preparation of Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of Human Immunodeficiency Virus (HIV) infections, which prevents the replication of the virus.

Synthesis

2-Chloro-4-methoxypyrimidine is prepared by the reaction of 2,4-Dichloropyrimidine and Sodium Methoxide. The specific synthesis steps are as follows:
To a solution of 2,4-dichloropyrimidine (41.8 g, 280 mmol) in methanol (900 mL)was added a solution of CH3ONa (15.2 g, 280 mmol) in 100 mL methanol at 0 °C. The mixturewas stirred at rt for overnight. The mixture was concentrated under reduce pressure to give awhite solid, which was diluted with water (400mL) and extracted with ethyl acetate (500 mL x3). The combined organic layer was washed with brine, dried, concentrated to give 2-chloro-4-methoxypyrimidine (40 g, yield: 98percent) as white solid. ESI-MS (M+H): 145.0. ‘H NMR (400 MHz, CDC13) (5: 8.30 (d, J= 5.6 Hz ,1H), 6.68 (s, J= 5.6 Hz ,1H), 4.02 (s, 3H).

2-CHLORO-4-METHOXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-METHOXYPYRIMIDINE Suppliers

China 173 Europe 1 Germany 1 India 15 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 4 United States 18 Global 215

Pure Chemistry Scientific Inc.

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Acme Bioscience, Inc.

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View Lastest Price from 2-CHLORO-4-METHOXYPYRIMIDINE manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Chloro-4-MethoxypyriMidine 22536-63-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-12

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-MethoxypyriMidine 22536-63-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

LY Global chemicals co.,ltd .

Product: 2-CHLORO-4-METHOXYPYRIMIDINE 22536-63-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-19

22536-63-6, 2-CHLORO-4-METHOXYPYRIMIDINERelated Search:

2-Chloro-4-methoxypyridine 2-Chloro-4,6-dimethoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine 2-CHLORO-4-METHOXYPYRIMIDINE 2-Amino-4-chloro-6-methoxypyrimidine 2,4-Dichloro-5-methoxypyrimidine 4-Amino-6-chloro-2-methoxypyrimidine 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE Chlorimuron 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 1-[2-(Ethoxycarbonyl)phenylsulfonyl]-3-(4-chloro-6-methoxypyrimidine-2-yl)urea 5-CHLORO-2-METHOXYPYRIMIDINE,PURITY:95% MIN(HPLC) 2-Methoxy-4,6-dichloropyrimidine 5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID 4-CHLORO-6-METHOXYPYRIMIDINE 2-Chloro-6-methoxyisonicotinoyl chloride 4,6-Dichloro-5-methoxypyrimidine 2-Chloro-5-methoxypyrimidine

2-CHLORO-4-METHOXYPYRIMIDINE

Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI)

2-Chloro-6-methoxypyrimidine

2-Chloro-4-methoxy-1,2-diazine

2-Chloro-4-methoxypyrimidine 98%

Pyrimidine, 2-chloro-4-methoxy-

2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH

2-chloro-4-methoxy pyrimdine

22536-63-6

Building Blocks

Pyrimidines

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocycle-Pyrimidine series

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

pharmacetical

Halides

Pyrazines, Pyrimidines & Pyridazines

Pyrimidines

PYRIMIDINE