ChemicalBook > CAS DataBase List > Trifluoroacetic anhydride

Trifluoroacetic anhydride

Product Name
Trifluoroacetic anhydride
CAS No.
407-25-0
Chemical Name
Trifluoroacetic anhydride
Synonyms
TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;uoroacetic anhydride;trimethylamine (TMA);TRIFLUOROACETO ANHYDRIDE
CBNumber
CB6853606
Molecular Formula
C4F6O3
Formula Weight
210.03
MOL File
407-25-0.mol
More
Less

Trifluoroacetic anhydride Property

Melting point:
-65 °C (lit.)
Boiling point:
39.5-40 °C (lit.)
Density 
1.511 g/mL at 20 °C (lit.)
vapor pressure 
6.28 psi ( 20 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
-26 °C
storage temp. 
2-8°C
solubility 
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form 
Liquid
pka
0.43[at 20 ℃]
Specific Gravity
1.487
color 
Clear
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
746197
Stability:
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP
0.79 at 25℃
CAS DataBase Reference
407-25-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System
Acetic acid, trifluoro-, anhydride (407-25-0)
More
Less

Safety

Hazard Codes 
C,T
Risk Statements 
14-20-35-52/53-34-23/24/25
Safety Statements 
26-36/37/39-43-45-61-9-8-28A-27
RIDADR 
UN 3265 8/PG 1
WGK Germany 
2
RTECS 
AJ9800000
F 
3-10
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
T
HazardClass 
8
PackingGroup 
I
HS Code 
29159080
Toxicity
skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
25mL
Price
$43.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
100mL
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
106232
Product name
Trifluoroacetic anhydride
Purity
ReagentPlus , ≥99%
Packaging
10x1g
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08261
Product name
Trifluoroacetic anhydride
Purity
for synthesis
Packaging
500mL
Price
$456
Updated
2024/03/01
Sigma-Aldrich
Product number
106232
Product name
Trifluoroacetic anhydride
Purity
ReagentPlus , ≥99%
Packaging
3kg
Price
$1460
Updated
2024/03/01
More
Less

Trifluoroacetic anhydride Chemical Properties,Usage,Production

Description

Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols. 

Chemical Properties

Clear, colorless liquid

Uses

Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.

Uses

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Preparation

Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C. 

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Raw materials

DICHLOROACETIC ANHYDRIDE Trifluoroacetic acid

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 2-Hydroxy-4-(trifluoromethyl)pyrimidine 5-Bromo-2-hydroxymethylpyridine 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 2-Chloro-4-(trifluoromethyl)pyrimidine [BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE 6-Aminobenzothiazole 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 2,6-DICHLORO-4-ISOCYANATOPYRIDINE Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)pyrazole 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE Chlorfenapyr (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine 4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 3-Nitroisonicotinic acid Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 5-Iodo-2,4-dimethoxypyrimidine N10-(TRIFLUOROACETYL)PTEROIC ACID 3-Amino-4-nitrobenzitrifluoride 2-(TRIFLUOROACETYL)THIOPHENE 2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Epirubicin 2-(Bromomethyl)-6-methylpyridine 5-Bromopyridine-2-carbaldehyde ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 3-CHLORO-5-NITROPYRIDINE [Bis(trifluoroacetoxy)iodo]benzene
More
Less

Trifluoroacetic anhydride Suppliers

Australia 2 Austria 1 Belgium 6 Brazil 1 Canada 2 China 366 Europe 4 France 4 Germany 10 India 42 Ireland 1 Italy 1 Japan 13 Norway 1 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 1 United Kingdom 20 United States 66 Global 547
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
CovaChem, LLC.
Tel
+1815.714.8421 (direct)
Fax
+1815.315.1272
Email
tonynooner@covachem.com
Country
United States
ProdList
89
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Monomer Polymer & Dajac Labs
Tel
--
Fax
--
Email
info@monomerpolymer.com
Country
United States
ProdList
1609
Advantage
58
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
Soltec Bio Science
Tel
--
Fax
--
Email
sales@soltecventures.com
Country
United States
ProdList
38
Advantage
58
Voigt Global Distribution Inc
Tel
--
Fax
--
Email
Sales@Vgdusa.Com
Country
United States
ProdList
110
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
ChemSci Technologies, Inc.
Tel
--
Fax
--
Email
chemscitech@gmail.com
Country
United States
ProdList
16
Advantage
58
Chem-Impex International, Inc. (CII)
Tel
--
Fax
--
Email
Customer@chemimpex.com
Country
United States
ProdList
893
Advantage
58
Jaytick Chemicals Inc.
Tel
--
Fax
--
Email
info@jaytick.com
Country
United States
ProdList
64
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
Halocarbon Life Sciences, LLC
Tel
--
Fax
--
Email
info@halocarbon.com
Country
United States
ProdList
3
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Wego Chemical Group
Tel
--
Fax
--
Email
sales@wegochem.com
Country
United States
ProdList
443
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Strem Chemicals, Inc.
Tel
--
Fax
--
Email
info@strem.com
Country
United States
ProdList
4910
Advantage
86
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Rare Earth Products Inc
Tel
--
Fax
--
Email
sales@rareearthproducts.com
Country
United States
ProdList
1095
Advantage
58
GFS Chemicals Inc
Tel
--
Fax
--
Email
service@gfschemicals.com
Country
United States
ProdList
2329
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Daniel Lab Canada
Tel
--
Fax
--
Country
United States
ProdList
273
Advantage
50
Advance Research Chemicals, Inc.
Tel
--
Fax
--
Email
sales@fluoridearc.com
Country
United States
ProdList
297
Advantage
60
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Regis Technologies, Inc.
Tel
--
Fax
--
Email
sales@registech.com
Country
United States
ProdList
148
Advantage
71
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Solvay Fluorides, Inc.
Tel
--
Fax
--
Email
annette.daubner@solvay.com
Country
United States
ProdList
9
Advantage
60
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Loba Chemie Pvt. Ltd.
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
71
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
Solvay Fluorides, LLC
Tel
--
Fax
--
Email
Wilfried.Moritz@solvay.com
Country
United States
ProdList
59
Advantage
60
Solvay Chemicals
Tel
--
Fax
--
Email
Chemicals@solvay.com
Country
United States
ProdList
72
Advantage
77
Wintersun Chemical
Tel
--
Fax
--
Email
purchasing@wintersunchem.com
Country
United States
ProdList
776
Advantage
68
Halocarbon Products Corporation
Tel
--
Fax
--
Email
Jens.ludwig@solvadis.com
Country
United States
ProdList
44
Advantage
76
More
Less

View Lastest Price from Trifluoroacetic anhydride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Trifluoroacetic anhydride 407-25-0
Price
US $19.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
Trifluoroacetic Anhydride 407-25-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99.7%
Supply Ability
10 ton
Release date
2024-08-20
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
Trifluoroacetic anhydride 407-25-0
Price
US $25.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2t
Release date
2022-01-05

407-25-0, Trifluoroacetic anhydrideRelated Search:

Glutaric anhydride Ethyl trifluoroacetate Succinic anhydride Isatoic Anhydride Trifluoromethanesulfonic anhydride Phthalic anhydride CIS-BUTENEDIOIC ANHYDRIDE Trifluoroacetic acid Sodium trifluoroacetate Potassium trifluoroacetate Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester Trifluoromethanesulfonic acid Trifluoroacetamide Trifluoroacetophenone Trifluoroacetamidine Acetic anhydride 2,2,2-TRIFLUOROETHYL METHYL ETHER 2-Fluoroethanol Trifluoroacetic Acid Anhydride

  • TIFLUOROACETIC ANHYDRIDE
  • TRIFLUOROACETO ANHYDRIDE
  • Trifluoroacetic acid anhydride (TFAH)
  • RIFLUOROACETIC ANHYDRIDE
  • Trifluoroacetic anhydride 10g [407-25-0]
  • Trifluoroacetic anhy
  • Trifluoroacetic anhydride, min. 98%
  • trifluoroacetyl 2,2,2-trifluoroacetate
  • Trifluoroacetic anhydride, 99+% 100GR
  • Trifluoroacetic anhydride, 99+% 25GR
  • 2,2,2-Trifluoroacetic anhydride
  • Trifluoracetic anhydride, min. 98%
  • Bis(2,2,2-trifluoroacetic acid)anhydride
  • Bis(trifluoroacetic acid) anhydride
  • Di(trifluoroacetic)anhydride
  • Trifluoroacetyltrifluoroacetate
  • Trifluoroethanoicanhydride
  • TFAA
  • TRIFLUORACETIC ANHYDRIDE
  • TRIFLUOROACETIC ANHYDRIDE
  • TRIFLUOROACETIC ACID ANHYDRIDE
  • BIS(TRIFLUOROACETIC) ANHYDRIDE
  • Triflyuoroacetic anhydride
  • uoroacetic anhydride
  • Trifluoroacetic anhydride 407-25-0 fiona
  • trifluorocytic anhydride fiona
  • TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%
  • Aceticacid,trifluoro-,anhydride
  • Anhydrid kyseliny trifluoroctove
  • anhydridkyselinytrifluoroctove
  • Hexafluoroacetic anhydride
  • hexafluoroaceticanhydride
  • Perfluoroacetic anhydride
  • perfluoroaceticanhydride
  • TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
  • TRIFLUOROACETIC ANHYDRIDE, DERIVATIZA-TI ON REAGENT
  • TRIFLUOROACETIC ANHYDRIDE REAGENTPLUS(&
  • TrifluoroaceticAnhydride/Tfaa/Tfah/Trifluoroaceticanhydride
  • TrifluoroaceticAnhydride/Tfaa
  • Trifluoroacetic anhydride, 99+%
  • Trifluoraceticanhydride,min.98%
  • TRIFLUOROACETICANHYDRIDE,REAGENT
  • Trifluoressigsureanhydrid
  • Perfluoracetic anhydride
  • TRIFLUOROACETIC ANHYDRIDE: 99.5%
  • TRIFLUOROACETIC ANHYDRIDE FOR SYNTHESIS
  • TRIFLUOROACETIC ANHYDRIDE FOR GAS CHROMA
  • Trifluoroacetic anhydride 99%
  • TRIFLUOROACETIC ANHYDRINE
  • TFAH)Trifluoroacetic anhyd
  • 1,1,1,5,5,5-Hexafluoro-3-oxapentan-2,4-dione, Perfluoro(3-oxapentan-2,4-dione), 2,2,2-Trifluoroethanoic anhydride
  • Aceticacid, 2,2,2-trifluoro-, 1,1'-anhydride
  • Three fluorineacetic anhydride
  • trimethylamine (TMA)
  • Trifluoroacetic anhydride ReagentPlus(R), >=99%
  • Trifluoroacetyl 2,2,2-trifluoroacetate (Trifluoroacetic anhydride)
  • Trifluoroacetic anhydride≥ 99% (GC)
  • TFAA Trifluoroacetic acid anhydride