2-Amino-4-chloropyridine

Product Name: 2-Amino-4-chloropyridine
CAS No.: 19798-80-2
Chemical Name: 2-Amino-4-chloropyridine
Synonyms: 4-CHLOROPYRIDIN-2-AMINE;4-chloro-2-pyridinamine;4-CHLORO-PYRIDINE-2-YLAMINE;DK765;cas:19798-80-2;IFLAB-BB F1926-0004;4-Chloropyrid-2-ylaMine;2-AMINO-4-CHLOROPYRIDINE;4-Chloro-2-aminopyridine;4-Chloro-2-amine-pyridin
CBNumber: CB7183078
Molecular Formula: C5H5ClN2
Formula Weight: 128.56
MOL File: 19798-80-2.mol

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2-Amino-4-chloropyridine Property

Melting point:: 126-127°C
Boiling point:: 240.8±20.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: 5.72±0.11(Predicted)
form: Liquid
color: Colorless to yellow to brown
λmax: 294nm(CHCl3)(lit.)
Sensitive: Air & Moisture Sensitive
InChI: InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(Cl)=C1
CAS DataBase Reference: 19798-80-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 676020
Product name: 2-Amino-4-chloropyridine
Purity: 97%
Packaging: 5g
Price: $70.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 676020
Product name: 2-Amino-4-chloropyridine
Purity: 97%
Packaging: 25g
Price: $195
Updated: 2023/06/20

TCI Chemical

Product number: A2152
Product name: 2-Amino-4-chloropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $79
Updated: 2024/03/01

TCI Chemical

Product number: A2152
Product name: 2-Amino-4-chloropyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $237
Updated: 2024/03/01

Alfa Aesar

Product number: H59130
Product name: 2-Amino-4-chloropyridine, 97%
Packaging: 5g
Price: $54.65
Updated: 2024/03/01

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2-Amino-4-chloropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-4-chloropyridine is a useful precursor that could be used to synthesize 2-amino-4,5-dichloropyridine, 2-amino-3,4-dichloropyridine, and 2-amino-3,4,5-trichloropyridine[1].

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

Methyl 4-chloropicolinate hydrochloride in methanol was treated with hydrazine hydrate, resulting in the formation of a precipitate. The suspension was then stirred for 2 hours and the precipitated hydrazide was collected through filtration. The hydrazide was dissolved in 1N hydrochloric acid and the solution was cooled to a temperature between 0-5 ℃. A solution of sodium nitrite in water was then added dropwise, causing another precipitate to form. After stirring for 15 minutes, the precipitate was collected by filtration and washed with water. The moist precipitate was then combined with a mixture of acetic acid and water, and the resulting solution was heated in a steam bath until gas evolution stopped. The reaction mixture was cooled to room temperature, the pH was adjusted to 7, and the resulting precipitate was collected via filtration. Recrystallization using ethanol yielded 2-Amino-4-chloropyridine in the form of a white crystalline solid[1].

References

[1] Gudmundsson, Kristjan S. , et al. "An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines." Synthetic Communications 27.5(1997):861-870.

2-Amino-4-chloropyridine Preparation Products And Raw materials

Raw materials

Hexane Ammonium hydroxide Hydrazinium hydroxide solution Nitrogen N,N-Dimethylformamide Potassium hydroxide Acetone Sodium bromide Calcium chloride Toluene Sodium Hydrazine hydrate 1,4-Dioxane Sodium nitrite Tetrahydrofuran Diethyl ether Ethyl acetate Government regulation Dichloromethane Acetic acid Methanol Sodium hydroxide 2-Picolinic acid Thionyl chloride Sodium carbonate

Preparation Products

2-Amino-4-methoxypyridine (4-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

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2-Amino-4-chloropyridine Suppliers

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View Lastest Price from 2-Amino-4-chloropyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Amino-4-chloropyridine 19798-80-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500KGS
Release date: 2021-06-19

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Amino-4-chloropyridine 19798-80-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-07

Wuhan Boyuan Import & Export Co., LTD

Product: 2-Amino-4-chloropyridine 19798-80-2
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 50000tons
Release date: 2024-04-11

19798-80-2, 2-Amino-4-chloropyridineRelated Search:

ALTRENOGEST Pentachloropyridine 3-Aminophenol 2-Chloro-3-hydroxypyridine 4-Dimethylaminopyridine 6-Aminocaproic acid 3-Aminopyridine Glycine Tris(hydroxymethyl)aminomethane 2-Aminopyridine Clopidol N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester Oxalic acid 1-ethyl ester 2-AMINO-3-CHLOROPYRIDINE 6-AMINO-2-CHLOROPYRIDINE,2-AMINO-6-CHLOROPYRIDINE (6-CHLOROPYRIDIN-2-YLAMINE) 2-Amino-5-chloropyridine Edoxaban Impurity 12 (1R,2R,4S) tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

2-AMINO-4-CHLOROPYRIDINE

4-CHLOROPYRIDIN-2-AMINE

4-CHLORO-PYRIDIN-2-YLAMINE

4-CHLORO-PYRIDINE-2-YLAMINE

4-CHLORO-2-PYRIDINYLAMINE

IFLAB-BB F1926-0004

4-chloro-2-pyridinamine

4-Chloro-2-aminopyridine

2-Pyridinamine,4-chloro-(9CI)

cas:19798-80-2

2-Pyridinamine, 4-chloro-

2-AMINO-4-CHLOROPYRIDINE,4-CHLORO-PYRIDIN-2-YLAMINE

4-CHLORO-PYRIDIN-2-YLAMINE,97%

4-Chloro-2-amine-pyridin

2-Amino-4-chloropyridine ,98%

4-Chloropyridine-2-amine

2-Amino-4-Cholropyridine

4-Chloropyrid-2-ylaMine

l (4-Chloropyridin-2-yl)aMine

2-AMino-4-chloropyridine CAS 19798-80-2

2-AMino-4-chloropyridine 97%

2- aMino-4- chlorinepyridine

2-Amino-4-chloropyridine ISO 9001：2015 REACH

DK765

19798-80-2

19792-80-2

9798-80-2

1970.98-80-2

C5H6ClN2

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines, Pyrimidines, Purines and Pteredines

Heterocyclic Series

Amines and Anilines

Heterocycles

Amino-pyridine series

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides

Pharmaceutical intermediate

pharmacetical

Pyridine series

Amines

OLED materials,pharm chemical,electronic

Aromatics

Building Blocks

C5

C5 to C6

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

PYRIDINE

blocks

Pyridines

bc0001