ChemicalBook > CAS DataBase List > 2-Amino-4-chloropyridine

2-Amino-4-chloropyridine

Product Name
2-Amino-4-chloropyridine
CAS No.
19798-80-2
Chemical Name
2-Amino-4-chloropyridine
Synonyms
4-CHLOROPYRIDIN-2-AMINE;4-chloro-2-pyridinamine;4-CHLORO-PYRIDINE-2-YLAMINE;DK765;cas:19798-80-2;IFLAB-BB F1926-0004;4-Chloropyrid-2-ylaMine;2-AMINO-4-CHLOROPYRIDINE;4-Chloro-2-aminopyridine;4-Chloro-2-amine-pyridin
CBNumber
CB7183078
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
19798-80-2.mol
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2-Amino-4-chloropyridine Property

Melting point:
126-127°C
Boiling point:
240.8±20.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
5.72±0.11(Predicted)
form 
Liquid
color 
Colorless to yellow to brown
λmax
294nm(CHCl3)(lit.)
Sensitive 
Air & Moisture Sensitive
InChI
InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
InChIKey
RQMWVVBHJMUJNZ-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(Cl)=C1
CAS DataBase Reference
19798-80-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
676020
Product name
2-Amino-4-chloropyridine
Purity
97%
Packaging
5g
Price
$70.1
Updated
2023/06/20
Sigma-Aldrich
Product number
676020
Product name
2-Amino-4-chloropyridine
Purity
97%
Packaging
25g
Price
$195
Updated
2023/06/20
TCI Chemical
Product number
A2152
Product name
2-Amino-4-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$79
Updated
2024/03/01
TCI Chemical
Product number
A2152
Product name
2-Amino-4-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$237
Updated
2024/03/01
Alfa Aesar
Product number
H59130
Product name
2-Amino-4-chloropyridine, 97%
Packaging
5g
Price
$54.65
Updated
2024/03/01
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2-Amino-4-chloropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-4-chloropyridine is a useful precursor that could be used to synthesize 2-amino-4,5-dichloropyridine, 2-amino-3,4-dichloropyridine, and 2-amino-3,4,5-trichloropyridine[1].

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

Methyl 4-chloropicolinate hydrochloride in methanol was treated with hydrazine hydrate, resulting in the formation of a precipitate. The suspension was then stirred for 2 hours and the precipitated hydrazide was collected through filtration. The hydrazide was dissolved in 1N hydrochloric acid and the solution was cooled to a temperature between 0-5 ℃. A solution of sodium nitrite in water was then added dropwise, causing another precipitate to form. After stirring for 15 minutes, the precipitate was collected by filtration and washed with water. The moist precipitate was then combined with a mixture of acetic acid and water, and the resulting solution was heated in a steam bath until gas evolution stopped. The reaction mixture was cooled to room temperature, the pH was adjusted to 7, and the resulting precipitate was collected via filtration. Recrystallization using ethanol yielded 2-Amino-4-chloropyridine in the form of a white crystalline solid[1].

References

[1] Gudmundsson, Kristjan S. , et al. "An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines." Synthetic Communications 27.5(1997):861-870.

2-Amino-4-chloropyridine Preparation Products And Raw materials

Raw materials

Hexane Ammonium hydroxide Hydrazinium hydroxide solution Nitrogen N,N-Dimethylformamide Potassium hydroxide Acetone Sodium bromide Calcium chloride Toluene Sodium Hydrazine hydrate 1,4-Dioxane Sodium nitrite Tetrahydrofuran Diethyl ether Ethyl acetate Government regulation Dichloromethane Acetic acid Methanol Sodium hydroxide 2-Picolinic acid Thionyl chloride Sodium carbonate

Preparation Products

2-Amino-4-methoxypyridine (4-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
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View Lastest Price from 2-Amino-4-chloropyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-4-chloropyridine 19798-80-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500KGS
Release date
2021-06-19
Hebei Weibang Biotechnology Co., Ltd
Product
2-Amino-4-chloropyridine 19798-80-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Wuhan Boyuan Import & Export Co., LTD
Product
2-Amino-4-chloropyridine 19798-80-2
Price
US $15.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
50000tons
Release date
2024-04-11

19798-80-2, 2-Amino-4-chloropyridineRelated Search:

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  • 2-AMINO-4-CHLOROPYRIDINE
  • 4-CHLOROPYRIDIN-2-AMINE
  • 4-CHLORO-PYRIDIN-2-YLAMINE
  • 4-CHLORO-PYRIDINE-2-YLAMINE
  • 4-CHLORO-2-PYRIDINYLAMINE
  • IFLAB-BB F1926-0004
  • 4-chloro-2-pyridinamine
  • 4-Chloro-2-aminopyridine
  • 2-Pyridinamine,4-chloro-(9CI)
  • cas:19798-80-2
  • 2-Pyridinamine, 4-chloro-
  • 2-AMINO-4-CHLOROPYRIDINE,4-CHLORO-PYRIDIN-2-YLAMINE
  • 4-CHLORO-PYRIDIN-2-YLAMINE,97%
  • 4-Chloro-2-amine-pyridin
  • 2-Amino-4-chloropyridine ,98%
  • 4-Chloropyridine-2-amine
  • 2-Amino-4-Cholropyridine
  • 4-Chloropyrid-2-ylaMine
  • l (4-Chloropyridin-2-yl)aMine
  • 2-AMino-4-chloropyridine CAS 19798-80-2
  • 2-AMino-4-chloropyridine 97%
  • 2- aMino-4- chlorinepyridine
  • 2-Amino-4-chloropyridine ISO 9001：2015 REACH
  • DK765
  • 19798-80-2
  • 19792-80-2
  • 9798-80-2
  • 1970.98-80-2
  • C5H6ClN2
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Heterocyclic Series
  • Amines and Anilines
  • Heterocycles
  • Amino-pyridine series
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Nucleotides
  • Pharmaceutical intermediate
  • pharmacetical
  • Pyridine series
  • Amines
  • OLED materials,pharm chemical,electronic
  • Aromatics
  • Building Blocks
  • C5
  • C5 to C6
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PYRIDINE
  • blocks
  • Pyridines
  • bc0001