ChemicalBook > CAS DataBase List > Isonipecotic acid

Isonipecotic acid

Product Name
Isonipecotic acid
CAS No.
498-94-2
Chemical Name
Isonipecotic acid
Synonyms
PIPERIDINE-4-CARBOXYLIC ACID;4-PIPERIDINECARBOXYLIC ACID;Inp-OH;H-INP-OH;H-PIC(4)-OH;h-dl-inp-oh;Isonipecotic aci;sonipecotic acid;ISONIPECOTIC ACID;AKOS BBS-00003783
CBNumber
CB7426775
Molecular Formula
C6H11NO2
Formula Weight
129.16
MOL File
498-94-2.mol
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Isonipecotic acid Property

Melting point:
>300 °C(lit.)
Boiling point:
239.22°C (rough estimate)
Density 
1.1426 (rough estimate)
refractive index 
1.4587 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Water
form 
Powder
pka
pK1:3.73(+1);pK2:10.72(0) (25°C)
color 
White to faint pink-beige
Water Solubility 
soluble
Merck 
14,5189
BRN 
112553
CAS DataBase Reference
498-94-2(CAS DataBase Reference)
EPA Substance Registry System
4-Piperidinecarboxylic acid (498-94-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
NS5150000
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I18008
Product name
Isonipecotic acid
Purity
97%
Packaging
25g
Price
$53.8
Updated
2024/03/01
Sigma-Aldrich
Product number
I18008
Product name
Isonipecotic acid
Purity
97%
Packaging
100g
Price
$116
Updated
2024/03/01
TCI Chemical
Product number
I0256
Product name
4-Piperidinecarboxylic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
I0256
Product name
4-Piperidinecarboxylic Acid
Purity
>98.0%(T)
Packaging
100g
Price
$53
Updated
2024/03/01
Alfa Aesar
Product number
A11795
Product name
Isonipecotic acid, 98%
Packaging
25g
Price
$47.65
Updated
2024/03/01
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Isonipecotic acid Chemical Properties,Usage,Production

Chemical Properties

white to faint pink-beige powder

Uses

A GABA-A receptor partial agonist

Synthesis Reference(s)

Synthesis, p. 623, 1984
Tetrahedron Letters, 35, p. 8783, 1994 DOI: 10.1016/S0040-4039(00)78497-8

Purification Methods

It crystallises from H2O or EtOH as needles. The hydrochloride recrystallises from H2O or aqueous HCl with m 293odec (also 298odec, 300odec). [Wibaut Recl Trav Chim Pays-Bas 63 141 1944, IR: Zacharius et al. J Am Chem Soc 76 2908 1954, Beilstein 22/1 V 244.]

Isonipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-BOC-ISONIPECOTIC ACID 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID 1-ACETYLISONIPECOTOYL CHLORIDE PHENYL(PIPERIDIN-4-YL)METHANONE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde 1-ACETYL-4-BENZOYLPIPERIDINE N-BOC-piperidine-4-carboxylic acid 4-(Boc-Aminomethyl)piperidine 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 1-Methylpiperidin-4-amine 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 1-Boc-4-(aminomethyl)piperidine 1-Acetyl-4-piperidinecarboxylic acid 4-Benzylpiperidine 4-N-BOC-Aminopiperidine 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 4-Cyanopiperidine 1-Boc-4-cyanopiperidine 1-(PIPERIDIN-4-YLCARBONYL)PIPERIDINE
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498-94-2, Isonipecotic acidRelated Search:

2,2,6,6-Tetramethyl-4-piperidinol Citric acid Isonipecotic acid ethyl,ISONIPECOTIC ACID ETHYL ESTER Folic acid DROPERIDOL ISONIPECOTIC ACID, METHYL AND ETHYL ESTERS,Isonipecotic acid methyl Hyaluronic acid Triacetonediamine Haloperidol Ethyl 2-(Chlorosulfonyl)acetate Benzyl 4-hydroxy-1-piperidinecarboxylate Ascoric Acid Azido-PEG1-CH2CO2H 4-HYDROXY-3-METHYLBENZOIC ACID Hexahydroisonicotinamide 4-Pyrimidinecarboxylic acid 4,4-Piperidinediol hydrochloride PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE

  • Isonipecotic acid, 4-Carboxypiperidine
  • 4 - piperidine forMic acid
  • Isonipecotic aci
  • Isonipecotic acid, 99% 25GR
  • Piperidin-4-carboxylic acid
  • 4-PIPERIDINECARBOXYLIC ACID FOR SYNTHESI
  • Piperidine-4-carboxylic acid or isonipecotic acid
  • AKOS BBS-00003783
  • DL-ISOPIPECOLINIC ACID
  • H-PIC(4)-OH
  • ISONIPECOTIC ACID
  • HEXAHYDROISONICOTINIC ACID
  • H-INP-OH
  • H-ISONICOT(H6)-OH
  • L-ISONIPECOTIC ACID
  • LABOTEST-BB LT00847733
  • 4-hexahydroisonicotinicacid
  • acideisonipecotique
  • acidepiperidine-carboxylique-4
  • TIMTEC-BB SBB004231
  • 4-CARBOXYPIPERIDINE
  • 4-PIPERIDINECARBOXYLIC ACID
  • sonipecotic acid
  • DL-ISOPIPECOLINIC ACID / 4-PIPERIDINECARBOXYLIC ACID
  • Inp-OH
  • Isonipecotic acid≥ 99% (Titration)
  • 4-Piperidinecarboxylic acid for synthesis
  • IsonipecoticAcid98%
  • 4-PiperidinecarboxylicAcid/IsonipecoticAcid
  • (n)-piperidine-4-carboxylic acid
  • h-dl-inp-oh
  • Piperidine-4-carboxylic acid 98%
  • 4-PIPERIDINECARBOXLIC ACID
  • PIPERIDINE-4-CARBOXYLIC ACID , ISONIPECOTIC ACID
  • PIPERIDIN-4-YLCARBOXYLIC ACID
  • ISONIPECOTIC ACID PIPERIDINE-4-CARBOXYLIC ACID
  • 4-[(1-oxopropyl)phenylamino]-1-(phenylmethyl)-
  • 4-Piperidinecarboxylic acid, Hexahydroisonicotinic acid
  • 4-Piperidinecarboxylic acid ,98%
  • Piperidine-4-carbonic acid
  • Isonipecotic acid,99%
  • Isonipecotic acid , 97+%
  • 4-acid piperidine
  • Isonipecotic acid, 99% 100GR
  • RARECHEM AH CK 0178
  • PIPERIDINE-4-CARBOXYLIC ACID
  • 4-Piperidinecaboxylic Acid
  • DL-Isonipecotic acid
  • H-DL-Inp-OH~(+/-)-Piperidine-4-carboxylic acid
  • Hexahydroisonicotine acid
  • 4-PiperidinecarboxylicAcid&gt
  • Isonipecotic acid ISO 9001：2015 REACH
  • 4-Piperidinecarboxylic acid (9CI, ACI)
  • Avatrombopag Impurity 67
  • 4-piperidinic acid
  • 498-94-2
  • 198-94-2
  • C23H28N2O3C2H2O4