ChemicalBook > CAS DataBase List > Fmoc-Pro-OH

Fmoc-Pro-OH

Product Name
Fmoc-Pro-OH
CAS No.
71989-31-6
Chemical Name
Fmoc-Pro-OH
Synonyms
FMOC-PRO-OH;FMOC-PRO;FMOC-L-;FMOC-L-PRO-OH;FMOC-L-PRO;FMOC-PRO-OH H2O;FMOC-PROLINE;L-PROLINE-N-FMOC;FMOC-L-PRO-OH H2O;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
CBNumber
CB8189794
Molecular Formula
C20H19NO4
Formula Weight
337.37
MOL File
71989-31-6.mol
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Fmoc-Pro-OH Property

Melting point:
117-118 °C(lit.)
alpha 
-32 º (c=1,DMF)
Boiling point:
473.68°C (rough estimate)
Density 
1.2486 (rough estimate)
refractive index 
-32.5 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
Soluble in methanol. (almost transparency.)
form 
Solid
pka
3.95±0.20(Predicted)
color 
White to Off-White
optical activity
[α]20/D 32±1°, c = 1% in DMF
Concentration
0.1 mCi/ml
Solvent
Ethanol
Specific Activity
50-60 mCi/mmol
BRN 
3596735
CAS DataBase Reference
71989-31-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HS Code 
2933 99 80
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
25g
Price
$37.5
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
100g
Price
$71.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
250g
Price
$166
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$299
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$299
Updated
2025/07/31
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Fmoc-Pro-OH Chemical Properties,Usage,Production

Description

Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.

Chemical Properties

white to light yellow crystal powder.

Uses

L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

Preparation

To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).

General Description

Fmoc-Pro-OH has been instrumental in synthesizing peptides and proteins and in the development of new agents. Additionally, Fmoc-P-OH has been extensively employed in both in vivo and in vitro studies, with a focus on enzyme function, protein structure, and drug design investigations.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Fmoc-Pro-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Pro-OH Suppliers

Americas 1 Belgium 1 Canada 2 China 426 Europe 5 France 2 Germany 7 Hungary 1 India 41 Israel 2 Italy 2 Japan 8 Poland 1 Switzerland 7 United Kingdom 18 United States 76 Global 600
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Fmoc-Pro-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Fmoc-L-Proline 71989-31-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-22
Anhui Dexinjia Biopharm Co., Ltd
Product
Fmoc-Pro-OH 71989-31-6
Price
US $100.00-2500.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10MT per month
Release date
2025-06-17
Anhui Dexinjia Biopharm Co., Ltd
Product
Fmoc-L-Proline 71989-31-6
Price
US $300.00-7500.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
5MT per month
Release date
2025-05-19

71989-31-6, Fmoc-Pro-OHRelated Search:

L-Proline Fmoc-Aib-OH Fmoc-Asp(OtBu)-OH Fmoc-Lys(Boc)-OH L-PROLINE-(4-3H(N)) L-Fmoc-Aspartic acid alpha-tert-butyl ester cis-4-Hydroxy-L-proline D-Proline Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate 9-Fluorenemethanol FMOC-L-Methionine Fmoc-OSu FMOC-S-trityl-L-cysteine Fmoc-Trp(Boc)-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH Nalpha-FMOC-L-Tryptophan

  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-PROLINE
  • N-(9-FLUOROENYLMETHOXYCARBONYL)-L-SERINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-FMOC-L-PROLINE
  • 9-FLUORENYLMETHOXYCARBONYL-L-PROLINE
  • FMOC-L-PRO-OH
  • FMOC-L-PRO-OH H2O
  • FMOC-L-PROLINE
  • FMOC-L-PRO
  • FMOC-PROLINE
  • FMOC-PRO-OH
  • FMOC-PRO-OH H2O
  • FMOC-PYRD(2)-OH
  • FMOC-PRO
  • 1-(9H-fluoren-9-ylmethyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
  • FMOC-L-PROLINE 99+%
  • N-FMOC-PRO-OH ( N-FMOC-L-PROLINE)
  • L-Proline-UL-13C5, 15N-N-FMOC
  • L-PROLINE-N-FMOC
  • Fmoc-L-proline Fmoc-Pro-OH
  • (S)-1-(((9H-fluoren-9-yl)Methoxy)carbonyl)pyrrolidine-2-carboxylic acid
  • FMoc-Pro-OH >=99.0% (HPLC)
  • MOC-L-Proline
  • (S)-Fmoc-pyrrolidine-2-carboxylic acid
  • Fmoc-L-proline≥ 99.7% (HPLC, Chiral purity)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Pro-OH
  • FMOC-L-
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE(FMOC-L-PRO-OH)
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINE MONOHYDRATE
  • N-FMOC-L-PRO
  • N-FMOC-L-PROLINE
  • N-FMOC-PRO-OH
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE MONOHYDRATE
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PROLINE
  • 1-(9H-fFuoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
  • N-(9-Fluorenylmethoxycarbonyl)-L-proline ,98%
  • FMOC-L-PROLINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-L-proline, Fmoc-L-proline
  • (2S)-1,2-Pyrrolidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
  • 1-(9H-Fluorene-9-ylmethoxycarbonyl)proline
  • 1-[(9H-Fluorene-9-yl)methoxycarbonyl]-L-proline
  • 1-[(9H-Fluorene-9-ylmethoxy)carbonyl]-L-proline
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-L-proline
  • N-alpha-(9-fluorenylmethyloxycarbonyl)-L-proline
  • Fmoc-L-prolone
  • Fmoc-L-proline ,98%
  • Fmoc-Proline-OH
  • (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
  • FMOC-L-PRO-OH(71989-31-6)
  • FMOC-Pro-OH 98%
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline&gt
  • FMOC-PRO-OH 250 G
  • FMOC-PRO-OH 100 G
  • 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2S)-
  • (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylicaci
  • FMOC-L-Proline USP/EP/BP