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Fmoc-Pro-OH

Product Name
Fmoc-Pro-OH
CAS No.
71989-31-6
Chemical Name
Fmoc-Pro-OH
Synonyms
FMOC-PRO-OH;FMOC-PRO;FMOC-L-;FMOC-L-PRO-OH;FMOC-L-PRO;FMOC-PRO-OH H2O;FMOC-PROLINE;L-PROLINE-N-FMOC;FMOC-L-PRO-OH H2O;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
CBNumber
CB8189794
Molecular Formula
C20H19NO4
Formula Weight
337.37
MOL File
71989-31-6.mol
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Fmoc-Pro-OH Property

Melting point:
117-118 °C(lit.)
alpha 
-32 º (c=1,DMF)
Boiling point:
473.68°C (rough estimate)
Density 
1.2486 (rough estimate)
refractive index 
-32.5 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
Soluble in methanol. (almost transparency.)
form 
Solid
pka
3.95±0.20(Predicted)
color 
White to Off-White
optical activity
[α]20/D 32±1°, c = 1% in DMF
BRN 
3596735
Concentration
0.1 mCi/ml
Solvent
Ethanol
Specific Activity
50-60 mCi/mmol
CAS DataBase Reference
71989-31-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HS Code 
2933 99 80
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
25g
Price
$36.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
100g
Price
$70
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
250g
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52017
Product name
Fmoc-Pro-OH
Purity
Novabiochem?
Packaging
1kg
Price
$554
Updated
2024/03/01
Sigma-Aldrich
Product number
47636
Product name
Fmoc-Pro-OH
Purity
≥99.0% (HPLC)
Packaging
5G
Price
$36.4
Updated
2024/03/01
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Fmoc-Pro-OH Chemical Properties,Usage,Production

Description

Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.

Chemical Properties

white to light yellow crystal powder.

Uses

L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

Preparation

To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).

General Description

The product number for this product was previously 04-12-1031.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Fmoc-Pro-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Pro-OH Suppliers

Americas 1 Belgium 1 Canada 2 China 387 Europe 5 France 2 Germany 7 Hungary 1 India 40 Israel 2 Italy 2 Japan 8 Poland 1 Switzerland 7 United Kingdom 18 United States 76 Global 560
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Email
inquiry@watanabechem.co.jp
Country
Japan
ProdList
1918
Advantage
50
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Country
Japan
ProdList
4811
Advantage
42
Peptide Institute, Inc.
Tel
--
Fax
--
Email
info@peptide.co.jp
Country
Japan
ProdList
992
Advantage
70
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
Kokusan Chemical Co., Ltd.
Tel
--
Fax
--
Email
tech@kokusan-chem.co.jp
Country
Japan
ProdList
1658
Advantage
51
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from Fmoc-Pro-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Pro-OH 71989-31-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
FMOC-L-Proline 71989-31-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Henan Fengda Chemical Co., Ltd
Product
Fmoc-Pro-OH 71989-31-6
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-02

71989-31-6, Fmoc-Pro-OHRelated Search:

L-Proline Fmoc-Aib-OH Fmoc-Asp(OtBu)-OH Fmoc-Lys(Boc)-OH L-PROLINE-(4-3H(N)) L-Fmoc-Aspartic acid alpha-tert-butyl ester cis-4-Hydroxy-L-proline N-(9-Fluorenylmethoxycarbonyloxy)succinimide D-Proline Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate 9-Fluorenemethanol FMOC-L-Methionine FMOC-S-trityl-L-cysteine Fmoc-Trp(Boc)-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH Nalpha-FMOC-L-Tryptophan

  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-PROLINE
  • N-(9-FLUOROENYLMETHOXYCARBONYL)-L-SERINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-FMOC-L-PROLINE
  • 9-FLUORENYLMETHOXYCARBONYL-L-PROLINE
  • FMOC-L-PRO-OH
  • FMOC-L-PRO-OH H2O
  • FMOC-L-PROLINE
  • FMOC-L-PRO
  • FMOC-PROLINE
  • FMOC-PRO-OH
  • FMOC-PRO-OH H2O
  • FMOC-PYRD(2)-OH
  • FMOC-PRO
  • 1-(9H-fluoren-9-ylmethyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
  • FMOC-L-PROLINE 99+%
  • N-FMOC-PRO-OH ( N-FMOC-L-PROLINE)
  • L-Proline-UL-13C5, 15N-N-FMOC
  • L-PROLINE-N-FMOC
  • Fmoc-L-proline Fmoc-Pro-OH
  • (S)-1-(((9H-fluoren-9-yl)Methoxy)carbonyl)pyrrolidine-2-carboxylic acid
  • FMoc-Pro-OH >=99.0% (HPLC)
  • MOC-L-Proline
  • (S)-Fmoc-pyrrolidine-2-carboxylic acid
  • Fmoc-L-proline≥ 99.7% (HPLC, Chiral purity)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Pro-OH
  • FMOC-L-
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE(FMOC-L-PRO-OH)
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINE MONOHYDRATE
  • N-FMOC-L-PRO
  • N-FMOC-L-PROLINE
  • N-FMOC-PRO-OH
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE MONOHYDRATE
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PROLINE
  • 1-(9H-fFuoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
  • N-(9-Fluorenylmethoxycarbonyl)-L-proline ,98%
  • FMOC-L-PROLINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-L-proline, Fmoc-L-proline
  • (2S)-1,2-Pyrrolidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
  • 1-(9H-Fluorene-9-ylmethoxycarbonyl)proline
  • 1-[(9H-Fluorene-9-yl)methoxycarbonyl]-L-proline
  • 1-[(9H-Fluorene-9-ylmethoxy)carbonyl]-L-proline
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-L-proline
  • N-alpha-(9-fluorenylmethyloxycarbonyl)-L-proline
  • Fmoc-L-prolone
  • Fmoc-L-proline ,98%
  • Fmoc-Proline-OH
  • (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
  • FMOC-L-PRO-OH(71989-31-6)
  • FMOC-Pro-OH 98%
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline&gt
  • FMOC-PRO-OH 250 G
  • FMOC-PRO-OH 100 G
  • 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2S)-
  • (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylicaci
  • FMOC-L-Proline USP/EP/BP