Fmoc-Pro-OH

Product Name: Fmoc-Pro-OH
CAS No.: 71989-31-6
Chemical Name: Fmoc-Pro-OH
Synonyms: FMOC-PRO-OH;FMOC-PRO;FMOC-L-;FMOC-L-PRO-OH;FMOC-L-PRO;FMOC-PRO-OH H2O;FMOC-PROLINE;L-PROLINE-N-FMOC;FMOC-L-PRO-OH H2O;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
CBNumber: CB8189794
Molecular Formula: C20H19NO4
Formula Weight: 337.37
MOL File: 71989-31-6.mol

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Fmoc-Pro-OH Property

Melting point:: 117-118 °C(lit.)
alpha: -32 º (c=1,DMF)
Boiling point:: 473.68°C (rough estimate)
Density: 1.2486 (rough estimate)
refractive index: -32.5 ° (C=1, DMF)
storage temp.: Store below +30°C.
solubility: Soluble in methanol. (almost transparency.)
form: Solid
pka: 3.95±0.20(Predicted)
color: White to Off-White
optical activity: [α]20/D 32±1°, c = 1% in DMF
Concentration: 0.1 mCi/ml
Solvent: Ethanol
Specific Activity: 50-60 mCi/mmol
BRN: 3596735
CAS DataBase Reference: 71989-31-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 2933 99 80

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52017
Product name: Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 25g
Price: $37.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52017
Product name: Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 100g
Price: $71.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52017
Product name: Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 250g
Price: $166
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52017
Product name: Fmoc-Pro-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $299
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52017
Product name: Fmoc-Pro-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $299
Updated: 2025/07/31

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Fmoc-Pro-OH Chemical Properties,Usage,Production

Description

Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.

Chemical Properties

white to light yellow crystal powder.

Uses

L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

Preparation

To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).

General Description

Fmoc-Pro-OH has been instrumental in synthesizing peptides and proteins and in the development of new agents. Additionally, Fmoc-P-OH has been extensively employed in both in vivo and in vitro studies, with a focus on enzyme function, protein structure, and drug design investigations.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Fmoc-Pro-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Pro-OH Suppliers

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View Lastest Price from Fmoc-Pro-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Fmoc-L-Proline 71989-31-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-22

Anhui Dexinjia Biopharm Co., Ltd

Product: Fmoc-Pro-OH 71989-31-6
Price: US $100.00-2500.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10MT per month
Release date: 2025-06-17

Anhui Dexinjia Biopharm Co., Ltd

Product: Fmoc-L-Proline 71989-31-6
Price: US $300.00-7500.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: 5MT per month
Release date: 2025-05-19

71989-31-6, Fmoc-Pro-OHRelated Search:

L-Proline Fmoc-Aib-OH Fmoc-Asp(OtBu)-OH Fmoc-Lys(Boc)-OH L-PROLINE-(4-3H(N)) L-Fmoc-Aspartic acid alpha-tert-butyl ester cis-4-Hydroxy-L-proline D-Proline Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate 9-Fluorenemethanol FMOC-L-Methionine Fmoc-OSu FMOC-S-trityl-L-cysteine Fmoc-Trp(Boc)-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH Nalpha-FMOC-L-Tryptophan

N-9-FLUORENYLMETHYLOXYCARBONYL-L-PROLINE

N-(9-FLUOROENYLMETHOXYCARBONYL)-L-SERINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID

N-ALPHA-FMOC-L-PROLINE

9-FLUORENYLMETHOXYCARBONYL-L-PROLINE

FMOC-L-PRO-OH

FMOC-L-PRO-OH H2O

FMOC-L-PROLINE

FMOC-L-PRO

FMOC-PROLINE

FMOC-PRO-OH

FMOC-PRO-OH H2O

FMOC-PYRD(2)-OH

FMOC-PRO

1-(9H-fluoren-9-ylmethyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate

FMOC-L-PROLINE 99+%

N-FMOC-PRO-OH ( N-FMOC-L-PROLINE)

L-Proline-UL-13C5, 15N-N-FMOC

L-PROLINE-N-FMOC

Fmoc-L-proline Fmoc-Pro-OH

(S)-1-(((9H-fluoren-9-yl)Methoxy)carbonyl)pyrrolidine-2-carboxylic acid

FMoc-Pro-OH >=99.0% (HPLC)

MOC-L-Proline

(S)-Fmoc-pyrrolidine-2-carboxylic acid

Fmoc-L-proline≥ 99.7% (HPLC, Chiral purity)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Pro-OH

FMOC-L-

N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE(FMOC-L-PRO-OH)

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINE MONOHYDRATE

N-FMOC-L-PRO

N-FMOC-L-PROLINE

N-FMOC-PRO-OH

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINE MONOHYDRATE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PROLINE

1-(9H-fFuoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

N-(9-Fluorenylmethoxycarbonyl)-L-proline ,98%

FMOC-L-PROLINE extrapure

N-(9-Fluorenylmethoxycarbonyl)-L-proline, Fmoc-L-proline

(2S)-1,2-Pyrrolidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

1-(9H-Fluorene-9-ylmethoxycarbonyl)proline

1-[(9H-Fluorene-9-yl)methoxycarbonyl]-L-proline

1-[(9H-Fluorene-9-ylmethoxy)carbonyl]-L-proline

N-(9H-Fluorene-9-ylmethoxycarbonyl)-L-proline

N-alpha-(9-fluorenylmethyloxycarbonyl)-L-proline

Fmoc-L-prolone

Fmoc-L-proline ,98%

Fmoc-Proline-OH

(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

FMOC-L-PRO-OH(71989-31-6)

FMOC-Pro-OH 98%

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline&gt

FMOC-PRO-OH 250 G

FMOC-PRO-OH 100 G

1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2S)-

(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylicaci

FMOC-L-Proline USP/EP/BP