Mal-PEG2-amine Chemical Properties

Boiling point:

379.9±27.0 °C(Predicted)

Density 

1.226±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

Mal-PEG2-amine Usage And Synthesis

Description

Mal-PEG2-amine TFA salt is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Mal-PEG2-amine(660843-22-1)Related Product Information

• alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol)
• Mal-PEG3-NHS ester
• Mal-PEG6-COOH
• N-Succinimidyl 3-maleimidopropionate
• Mal-PEG4-NHS ester
• 3,4-Dibromo-Mal-PEG2-Amine
• Maleimido-Tri(Ethylene Glycol)-Propionic Acid
• Mal-PEG2-COOH
• N-[4-(-Carboxycyclohexylmethyl)]maleimide
• Mal-PEG4-Acid
• Mal-PEG2-NHS ester
• Bis-Mal-Lysine-PEG4-TFP ester
• Maleimide-PEG4-NHS Ester
• Maleimide-PEG2-NHS Ester
• 3-Maleimidopropionic acid
• Mal-PEG2-acid
• Mal-Amido-PEG4-acid
• 2-MALEIMIDOETHYLAMINE HCL