3,4-Dibromo-Mal-PEG2-Amine Chemical Properties

Boiling point:

425.1±45.0 °C(Predicted)

Density 

1.831±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

Safety Information

HS Code 

2933998090

3,4-Dibromo-Mal-PEG2-Amine Usage And Synthesis

Description

3,4-Dibromo-Mal-PEG2-Amine TFA salt is a PEG linker containing a dibromomaleimide group and a primary amine. The dibromomaleimide group allows for two points of attachement because both of the bromine atoms can be substituted. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. PEG linkers are hydrophilic moieties, therefore the attachment of a PEG linker to a compound increases it's water solubility properties in aqueous media.

Uses

3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

3,4-Dibromo-Mal-PEG2-Amine(1807534-86-6)Related Product Information

• Mal-PEG3-NHS ester
• Mal-PEG6-COOH
• N-Succinimidyl 3-maleimidopropionate
• Mal-PEG4-NHS ester
• Maleimido-Tri(Ethylene Glycol)-Propionic Acid
• Mal-PEG2-COOH
• N-[4-(-Carboxycyclohexylmethyl)]maleimide
• Mal-PEG4-Acid
• Mal-PEG2-NHS ester
• Bis-Mal-Lysine-PEG4-TFP ester
• Maleimide-PEG4-NHS Ester
• Maleimide-PEG2-NHS Ester
• 3-Maleimidopropionic acid
• Mal-PEG2-acid
• Mal-Amido-PEG4-acid
• 2-MALEIMIDOETHYLAMINE HCL
• 3,4-Dibromo-Mal-PEG2-Boc-Amine
• 3,4-Dibromo-Mal-PEG4-t-butyl ester