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E3 ligase Ligand-Linker Conjugates 50

Product Name
E3 ligase Ligand-Linker Conjugates 50
CAS No.
2271036-44-1
Chemical Name
E3 ligase Ligand-Linker Conjugates 50
Synonyms
Poma-PEG1-N3;Pomalidomide-PEG1-C2-N3;Cereblon Ligand-Linker Conjugates 13;E3 ligase Ligand-Linker Conjugates 50;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CBNumber
CB96127047
Molecular Formula
C17H18N6O5
Formula Weight
386.37
MOL File
2271036-44-1.mol
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E3 ligase Ligand-Linker Conjugates 50 Property

storage temp. 
-20°C, stored under nitrogen
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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E3 ligase Ligand-Linker Conjugates 50 Chemical Properties,Usage,Production

Biological Activity

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

storage

Store at -20°C

References

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 50 Suppliers

TargetMol Chemicals Inc.
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2271036-44-1, E3 ligase Ligand-Linker Conjugates 50Related Search:


  • E3 ligase Ligand-Linker Conjugates 50
  • Cereblon Ligand-Linker Conjugates 13
  • Pomalidomide-PEG1-C2-N3
  • 4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • Poma-PEG1-N3
  • 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
  • 2271036-44-1