ChemicalBook > CAS DataBase List > 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Product Name
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.
479633-63-1
Chemical Name
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2;Azilsartan medoxomil impurity345
CBNumber
CB32452480
Molecular Formula
C13H10ClN3O2S
Formula Weight
307.76
MOL File
479633-63-1.mol
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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Property

Melting point:
145.0 to 149.0 °C
Boiling point:
505.3±60.0 °C(Predicted)
Density 
1.49
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
powder to crystal
pka
1.73±0.30(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKey
BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000077
Product name
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Purity
Aldrich
Packaging
1g
Price
$761
Updated
2023/06/20
TCI Chemical
Product number
C3036
Product name
4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity
>96.0%(HPLC)(N)
Packaging
1g
Price
$74
Updated
2024/03/01
TCI Chemical
Product number
C3036
Product name
4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity
>96.0%(HPLC)(N)
Packaging
5g
Price
$296
Updated
2023/06/20
Apolloscientific
Product number
OR317249
Product name
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging
5g
Price
$327
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC10607
Product name
4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging
25g
Price
$472.5
Updated
2021/12/16
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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Uses

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Americas 1 China 332 Europe 1 Germany 3 India 25 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 24 Global 398
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View Lastest Price from 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-18
Shaanxi Dideu New Materials Co. Ltd
Product
4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-14
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tofacitinib Impurity 1 479633-63-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-20

479633-63-1, 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T

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  • Heterocycle-Pyrimidine series
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