2-Aminopyridine
Identification- Product Name
- 2-Aminopyridine
- CAS No.
- 504-29-0
- Chemical Name
- 2-Aminopyridine
- Synonyms
- PYRIDIN-2-YLAMINE;2-PYRIDINAMINE;2-amino-pyridin;2-PYRIDYLAMINE;2APY;NSC 431;AKOS 91158;AURORA KA-680;2-Pyridylamin;A-PYRIDYLAMINE
- CBNumber
- CB8152736
- Molecular Formula
- C5H6N2
- Formula Weight
- 94.11
- MOL File
- 504-29-0.mol
2-Aminopyridine Property
- Melting point:
- 59 °C
- Boiling point:
- 204-210 °C(lit.)
- Density
- 1.0308 (estimate)
- vapor pressure
- 5 hPa (125 °C)
- refractive index
- 1.5560 (estimate)
- Flash point:
- 198 °F
- storage temp.
- Store below +30°C.
- solubility
- 890g/l
- pka
- 6.82(at 20℃)
- form
- Crystalline Powder, Crystals or Flakes
- color
- Cream to light yellow-beige
- Odor
- Characteristic odour
- Water Solubility
- Slightly soluble. 1-5 g/100 mL at 19 ºC
- Sensitive
- Hygroscopic
- Merck
- 14,473
- BRN
- 105785
- Exposure limits
- NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 5 ppm; OSHA PEL: 0.5 ppm; ACGIH TLV: TWA 0.5 ppm.
- LogP
- 0.53
- CAS DataBase Reference
- 504-29-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinamine(504-29-0)
- EPA Substance Registry System
- 2-Aminopyridine (504-29-0)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 21-25-36/37/38-23/24/25
- Safety Statements
- 26-36/37/39-45-38-28B
- OEB
- B
- OEL
- TWA: 0.5 ppm (2 mg/m3)
- RIDADR
- UN 2671 6.1/PG 2
- WGK Germany
- 3
- RTECS
- US1575000
- F
- 8-21
- Autoignition Temperature
- >630 °C
- Hazard Note
- Toxic/Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
- Hazardous Substances Data
- 504-29-0(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 200 mg/kg
- IDLA
- 5 ppm
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.01113
- Product name
- 2-Aminopyridine
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $82.2
- Updated
- 2024/03/01
- Product number
- 8.01113
- Product name
- 2-Aminopyridine
- Purity
- for synthesis
- Packaging
- 500g
- Price
- $312
- Updated
- 2024/03/01
- Product number
- 09340
- Product name
- 2-Aminopyridine
- Purity
- purum, ≥98.0% (NT)
- Packaging
- 50g
- Price
- $33.7
- Updated
- 2024/03/01
- Product number
- 09340
- Product name
- 2-Aminopyridine
- Purity
- purum, ≥98.0% (NT)
- Packaging
- 250g
- Price
- $74.1
- Updated
- 2024/03/01
- Product number
- A0411
- Product name
- 2-Aminopyridine
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $18
- Updated
- 2024/03/01
2-Aminopyridine Chemical Properties,Usage,Production
Identification
2-Aminopyridine can be determined by the colourimetric method. UV spectroscopy can also be employed.
Analyte: 2-aminopyridine. Matrix: Air. Procedure: Adsorption on Tenax GC, thermal desorption, GC. Range 0.91-3.60 mg/cu m. Precision: 0.061. Sample size: 12 liters.
Pyridine and its derivatives in water and sediment were determined by gas chromatography. Recovery was 95, 90, and 84% from purified water, river water, and sediment, respectively. The detection limit was 0.001 mg/l water and 0.01 mg/l sediment.
An assay for the quantitative estimation of 4-aminopyridine in biological fluids is described using 2-aminopyridine as internal standard and ion-pair reversed-phase (C18) high-perfomance liquid chromatography with detection at 263 nm.
Chemical Properties
2-Aminopyridine is a yellow or white crystalline (sand-like) solid with a characteristic odor. It is soluble in water, alcohol, benzene, ether and hot petroleum ether. It tastes bitter and has anesthetic effect. It is a significant synthetic synthon, with unique dual nucleophilic structure. It can react with ketones, aldehydes, acids, multifunctional esters, halogenated aromatics and other compounds to synthesize five- and six-member azaheterocycles. after prolonged storage, may darken in color.
Uses
2-Aminopyridine is used primarily in the pharmaceutical industry as an intermediate in chemical synthesis. It is used to manufacturing analgesic and anti-inflammatory drugs piroxicam and lornoxicam. 2-Aminopyridine is a basic building block of several heterocyclic compounds and Schiff bases. It has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes. It is a derivatizing agent which can be used as a fluorescent label for oligosaccharide detection, chromatographic separation, fluorometric or mass spectrometric analysis. 2AP and its derivatives are good candidates for antimicrobial, anticorrosion and molecular sensing applications.
Preparation
2-Aminopyridine is manufactured using the reaction of pyridine with sodium amide (Chichibabin amination). It is obtained in high yield after the hydrolysis of the intermediate salt (Merck, 2001; Shimizu et al., 1993).
Application
2-Aminopyridine has also been used to derivatize sialyloligosaccharides for detection in FAB-MS. It can also be used:
As a reactant in the synthesis of 3-aroylimidazopyridines from chalcones by aerobic oxidative amidation using copper acetate catalyst.
In the synthesis of crystalline Cu(II) complex, di-μ-(2-aminopyridine(N,N′))-bis[(2,6 pyridinedicarboxylate)aquacopper(II)] tetrahydrate using 2,6-pyridinedicarboxylic acid and Cu(CH3COO)2.H2O.
As an imprinting molecule for the preparation of poly(methacrylic acid–ethylene glycol dimethacrylate) polymer. It is packed in micro-column for selective solid phase extraction of 2-aminopyridine.
As a reactant in the synthesis of 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones in the presence of Lewis acid catalysts.
As a reactant in the synthesis of 2-(2-aminopyridinium)acetyl starch with antioxidant property.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Tetrahedron Letters, 11, p. 3901, 1970
General Description
2-aminopyridine appears as white powder or crystals or light brown solid. It is soluble in water and alcohol. It is toxic by ingestion and by inhalation of the dust. It is used to make pharmaceuticals and dyes. (NTP, 1992)
Air & Water Reactions
Decomposes in air. Soluble in water.
Reactivity Profile
2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .
Hazard
Toxic.
Health Hazard
2-Aminopyridine causes central nervous system effects.
Fire Hazard
2-Aminopyridine is combustible.
Safety Profile
Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Toxic effects resemble strychnine poisoning. Human systemic effects by inhalation: somnolence, convulsions, and antipsychotic effects. Human central nervous system effects by inhalation. When heated to decomposition it emits highly toxic fumes of NOx,.
Potential Exposure
2-Aminopyridine is used in the manufacture of pharmaceuticals; especially antihistamines.
Carcinogenicity
The LD50 in mice by intraperitoneal injection
was 35 mg/kg; lethal doses in animals also
produced excitement, tremors, convulsions
and tetany.1 Fatal doses were readily absorbed
through the skin. A 0.2 M aqueous solution
dropped in a rabbit’s eye was only mildly
irritating.
2-Aminopyridine was not mutagenic in
a variety of Salmonella tester strains with or
without metabolic activation.
Environmental Fate
Soil. When radio-labeled 4-aminopyridine was incubated in moist soils (50%) under aerobic
conditions at 30 °C, the amount of 14CO2 released from an acidic loam (pH 4.1) and an alkaline,
loamy sand (pH 7.8) was 0.4 and 50%, respectively (Starr and Cunningham, 1975).
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and
Lewis, 1987).
Shipping
UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
It crystallises from *benzene/pet ether (b 40-60o) or CHCl3 /pet ether. [Beilstein 22/8 V 280.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides
Waste Disposal
Incineration with nitrogen oxides removal from effluent gas.
2-Aminopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Aminopyridine manufacturers
- Product
- 2-Aminopyridine 504-29-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31
- Product
- 2-aminopyridine 504-29-0
- Price
- US $59.00/kg
- Min. Order
- 1kg
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-11-13
- Product
- 2-Aminopyridine 504-29-0
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21