ChemicalBook > CAS DataBase List > 2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine

Product Name
2-Chloro-5-nitropyridine
CAS No.
4548-45-2
Chemical Name
2-Chloro-5-nitropyridine
Synonyms
Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
CBNumber
CB8853635
Molecular Formula
C5H3ClN2O2
Formula Weight
158.54
MOL File
4548-45-2.mol
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2-Chloro-5-nitropyridine Property

Melting point:
105-108 °C (lit.)
Boiling point:
256.6±20.0 °C(Predicted)
Density 
1.6616 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
158°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-4.22±0.10(Predicted)
form 
Crystalline Powder
color 
Light yellow to beige
Water Solubility 
Solubility in hot methanol. Insoluble in water.
BRN 
120453
InChI
InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey
BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference
4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Chloro-5-nitropyridine(4548-45-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
US7175000
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C61801
Product name
2-Chloro-5-nitropyridine
Purity
99%
Packaging
5g
Price
$36.9
Updated
2024/03/01
Sigma-Aldrich
Product number
C61801
Product name
2-Chloro-5-nitropyridine
Purity
99%
Packaging
25g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
C0025
Product name
2-Chloro-5-nitropyridine
Purity
>99.0%(GC)
Packaging
5g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
C0025
Product name
2-Chloro-5-nitropyridine
Purity
>99.0%(GC)
Packaging
25g
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
A10709
Product name
2-Chloro-5-nitropyridine, 99%
Packaging
25g
Price
$97.65
Updated
2024/03/01
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2-Chloro-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxychloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine

Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL 5-AMINO-2-METHOXY-ISONICOTINIC ACID 6-(1-PYRROLIDINYL)-3-PYRIDINAMINE 1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE 5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine
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2-Chloro-5-nitropyridine Suppliers

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View Lastest Price from 2-Chloro-5-nitropyridine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
2-Chloro-5-nitropyridine 4548-45-2
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Chloro-5-nitropyridine 4548-45-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min HPLC
Supply Ability
1000KGS
Release date
2021-07-15
Anhui Dexinjia Biopharm Co., Ltd
Product
2-Chloro-5-nitropyridine 4548-45-2
Price
US $15.00-50.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
5 ton per month
Release date
2023-03-26

4548-45-2, 2-Chloro-5-nitropyridineRelated Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol 1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine 3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE 2-Chloro-5-iodopyridine 5-Bromo-2-chlorobenzoic acid 2,4-DICHLORO-5-NITROPYRIDINE Difluorochloromethane

  • 2-Chloro-5-nitropyridine
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  • 2-Chloro-5-nitropyridine, 97+%
  • Chloro-5-nitropyrid
  • 2-chloro-5-nitro-pyridin
  • Chloronitropyridine,99%
  • 3-PYRIDINOL, 6-CHLORO-
  • 2-choro-5-nitropyridine
  • 2-CHLORO-5-NITROPYRIDINE (NON-REGULATED)
  • 2-CHLORO-5-NITROPYRIDINE (REGULATED)
  • 2-CHLORO-5-NITROPYRIDINE 99+%
  • Chloronitropyridine
  • 2-Chloro-5-nitropyridine &gt
  • 5-Bromo-4-methyl-2(2H)-pyridinone
  • 2-Chloro-5-nitropyridine ISO 9001：2015 REACH
  • 4548-45-2 ISO 9001：2015 REACH
  • 2-Chloro--nitropyridine
  • 2-chloro-5-nitripyridine
  • 2-Chlor-5-nitropyridin
  • Piroctone Impurity 3
  • 4548-45-2
  • 4548-48-2
  • C5H3CIN2O2
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • alkyl chloride |nitro-compound
  • Chlorinated heterocyclic series
  • Chloropyridines
  • Halopyridines
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridine series
  • Halides
  • Pyridines derivates
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Heterocycles
  • blocks
  • Pyridines
  • Pyridine
  • compounds of pyridine
  • 1
  • bc0001