2-Chloro-5-nitropyridine

Product Name: 2-Chloro-5-nitropyridine
CAS No.: 4548-45-2
Chemical Name: 2-Chloro-5-nitropyridine
Synonyms: Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
CBNumber: CB8853635
Molecular Formula: C5H3ClN2O2
Formula Weight: 158.54
MOL File: 4548-45-2.mol

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2-Chloro-5-nitropyridine Property

Melting point:: 105-108 °C (lit.)
Boiling point:: 256.6±20.0 °C(Predicted)
Density: 1.6616 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: 158°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -4.22±0.10(Predicted)
form: Crystalline Powder
color: Light yellow to beige
Water Solubility: Solubility in hot methanol. Insoluble in water.
BRN: 120453
InChI: InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey: BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference: 4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference: 2-Chloro-5-nitropyridine(4548-45-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: US7175000
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C61801
Product name: 2-Chloro-5-nitropyridine
Purity: 99%
Packaging: 5g
Price: $36.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: C61801
Product name: 2-Chloro-5-nitropyridine
Purity: 99%
Packaging: 25g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: C0025
Product name: 2-Chloro-5-nitropyridine
Purity: >99.0%(GC)
Packaging: 5g
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: C0025
Product name: 2-Chloro-5-nitropyridine
Purity: >99.0%(GC)
Packaging: 25g
Price: $49
Updated: 2024/03/01

Alfa Aesar

Product number: A10709
Product name: 2-Chloro-5-nitropyridine, 99%
Packaging: 25g
Price: $97.65
Updated: 2024/03/01

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2-Chloro-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxychloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine

Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL 5-AMINO-2-METHOXY-ISONICOTINIC ACID 6-(1-PYRROLIDINYL)-3-PYRIDINAMINE 1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE 5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine

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2-Chloro-5-nitropyridine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 4 China 490 Europe 4 France 1 Germany 7 Hungary 1 India 64 Ireland 1 Japan 4 Jordan 1 Poland 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 18 United States 61 Global 667

MDP ChemControl Ltd.

Tel: --
Fax: --
Email: chemcontrol@nextra.sk
Country: Slovakia
ProdList: 6700
Advantage: 60

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View Lastest Price from 2-Chloro-5-nitropyridine manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: 2-Chloro-5-nitropyridine 4548-45-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-14

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloro-5-nitropyridine 4548-45-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min HPLC
Supply Ability: 1000KGS
Release date: 2021-07-15

Anhui Dexinjia Biopharm Co., Ltd

Product: 2-Chloro-5-nitropyridine 4548-45-2
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2023-03-26

4548-45-2, 2-Chloro-5-nitropyridineRelated Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol 1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine 3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE 2-Chloro-5-iodopyridine 5-Bromo-2-chlorobenzoic acid 2,4-DICHLORO-5-NITROPYRIDINE Difluorochloromethane

2-Chloro-5-nitropyridine

3-Nitro-6-chloropyridine

2-Chloro-5-nitropyridine, 99% 25GR

5-Nitro-2-chloropyridine

6-Chloro-3-nitropyridine

2-Chloro-5-nitropyridine, 97+%

Chloro-5-nitropyrid

2-chloro-5-nitro-pyridin

Chloronitropyridine,99%

3-PYRIDINOL, 6-CHLORO-

2-choro-5-nitropyridine

2-CHLORO-5-NITROPYRIDINE (NON-REGULATED)

2-CHLORO-5-NITROPYRIDINE (REGULATED)

2-CHLORO-5-NITROPYRIDINE 99+%

Chloronitropyridine

2-Chloro-5-nitropyridine &gt

5-Bromo-4-methyl-2(2H)-pyridinone

2-Chloro-5-nitropyridine ISO 9001：2015 REACH

4548-45-2 ISO 9001：2015 REACH

2-Chloro--nitropyridine

2-chloro-5-nitripyridine

2-Chlor-5-nitropyridin

Piroctone Impurity 3

4548-45-2

4548-48-2

C5H3CIN2O2

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

alkyl chloride |nitro-compound

Chlorinated heterocyclic series

Chloropyridines

Halopyridines

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridine series

Halides

Pyridines derivates

Pyridines, Pyrimidines, Purines and Pteredines

Heterocycles

blocks

Pyridines

Pyridine

compounds of pyridine

1

bc0001