2-Chloro-5-nitropyridine
- Product Name
- 2-Chloro-5-nitropyridine
- CAS No.
- 4548-45-2
- Chemical Name
- 2-Chloro-5-nitropyridine
- Synonyms
- Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
- CBNumber
- CB8853635
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 4548-45-2.mol
2-Chloro-5-nitropyridine Property
- Melting point:
- 105-108 °C (lit.)
- Boiling point:
- 256.6±20.0 °C(Predicted)
- Density
- 1.6616 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- 158°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -4.22±0.10(Predicted)
- form
- Crystalline Powder
- color
- Light yellow to beige
- Water Solubility
- Solubility in hot methanol. Insoluble in water.
- BRN
- 120453
- InChI
- InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
- InChIKey
- BAZVFQBTJPBRTJ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C([N+]([O-])=O)C=C1
- CAS DataBase Reference
- 4548-45-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chloro-5-nitropyridine(4548-45-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- US7175000
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C61801
- Product name
- 2-Chloro-5-nitropyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $36.9
- Updated
- 2024/03/01
- Product number
- C61801
- Product name
- 2-Chloro-5-nitropyridine
- Purity
- 99%
- Packaging
- 25g
- Price
- $78
- Updated
- 2024/03/01
- Product number
- C0025
- Product name
- 2-Chloro-5-nitropyridine
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- C0025
- Product name
- 2-Chloro-5-nitropyridine
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- A10709
- Product name
- 2-Chloro-5-nitropyridine, 99%
- Packaging
- 25g
- Price
- $97.65
- Updated
- 2024/03/01
2-Chloro-5-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal
Uses
2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.
Uses
2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.
Synthesis
Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.
Purification Methods
It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]
2-Chloro-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-nitropyridine Suppliers
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View Lastest Price from 2-Chloro-5-nitropyridine manufacturers
- Product
- 2-Chloro-5-nitropyridine 4548-45-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2021-10-09
- Product
- 2-Chloro-5-nitropyridine 4548-45-2
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-07-31
- Product
- 2-Chloro-5-nitropyridine 4548-45-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-20