ChemicalBook > CAS DataBase List > 5-Bromo-2-chloro-3-nitropyridine

5-Bromo-2-chloro-3-nitropyridine

Product Name
5-Bromo-2-chloro-3-nitropyridine
CAS No.
67443-38-3
Chemical Name
5-Bromo-2-chloro-3-nitropyridine
Synonyms
5-Bromo-2-ch;RARECHEM AL BO 2390;IFLAB-BB F1957-0001;5-BROMO-2-PICOLINIC ACID;Medetomidine Impurity 65;5-BROMO-2-CARBOXYPYRIDINE;5-Bromo-2-chloro-3-nitrop...;2-CHLORO-5-BROMO-3-NITROPYRIDINE;2-Chloro-3-nitro-5-bromopyridine;5-BROMO-2-CHLORO-3-NITROPYRIDINE
CBNumber
CB8854096
Molecular Formula
C5H2BrClN2O2
Formula Weight
237.44
MOL File
67443-38-3.mol
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5-Bromo-2-chloro-3-nitropyridine Property

Melting point:
65-70 °C
Boiling point:
285.4±35.0 °C(Predicted)
Density 
1.936±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
-4.99±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow
InChI
InChI=1S/C5H2BrClN2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H
InChIKey
WWQQPSDIIVXFOX-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(Br)C=C1[N+]([O-])=O
CAS DataBase Reference
67443-38-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
36/37/38-21/22-41-37/38-25-22
Safety Statements 
37/39-26-45-36
RIDADR 
2811
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT, IRRITANT-HARMFUL
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
734756
Product name
5-Bromo-2-chloro-3-nitropyridine
Purity
97%
Packaging
5g
Price
$58.4
Updated
2023/06/20
TCI Chemical
Product number
B3963
Product name
5-Bromo-2-chloro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B3963
Product name
5-Bromo-2-chloro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$140
Updated
2025/07/31
TRC
Product number
B682370
Product name
5-Bromo-2-chloro-3-nitropyridine
Packaging
5g
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
021438
Product name
5-Bromo-2-chloro-3-nitropyridine
Purity
98%
Packaging
5g
Price
$14
Updated
2021/12/16
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5-Bromo-2-chloro-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

5-Bromo-2-chloro-3-nitropyridine is used as pharmaceutical intermediate.

Synthesis

6945-68-2

67443-38-3

The general procedure for the synthesis of 2-chloro-3-nitro-5-bromopyridine from 2-amino-3-nitro-5-bromopyridine was as follows: 2-amino-5-bromo-3-nitropyridine (21.8 g, 0.1 mol) was ground in a mortar and pestle to a fine powder, which was subsequently suspended in 6 M hydrochloric acid (250 ml). The mixture was cooled to 0 °C and solid NaNO2 (8.3 g, 0.12 mol) was slowly added while keeping the internal temperature below 5 °C (about 45 min). After addition, stirring was continued at 0 °C for 1 hour. To the resulting suspension was added a solution of freshly prepared copper(I) chloride (12.9 g, 0.13 mol) dissolved in degassed 38% hydrochloric acid, and the reaction mass was gradually warmed up to room temperature over 90 min, and then subsequently heated up to 70°C to complete the decomposition of the diazonium salt. The reaction mixture was cooled, diluted with water (750 ml), passed through air for 30 min, and the pH was subsequently adjusted by the addition of 0.88 ammonia to about 9. The blue mixture was mixed with ether (600 ml) and shaken, and the insoluble solids were removed by filtration. The organic layer was washed sequentially with 5% ammonia, water, and brine and dried with anhydrous sodium sulfate. After filtration, the solution was pre-adsorbed onto silica and purified by fast chromatography using a gradient elution of isohexane with 5% to 20% ethyl acetate to afford 5-bromo-2-chloro-3-nitropyridine as a light yellow solid (13.1 g, 55% yield) and to recover the starting material (6.4 g). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.36 (1H, d, J=1Hz, H-6), 8.69 (1H, d, J=1Hz, H-4).

References

[1] Patent: WO2007/129044, 2007, A1. Location in patent: Page/Page column 77
[2] Patent: EP1214319, 2003, B1. Location in patent: Page/Page column 13
[3] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 2, p. 261 - 268
[4] Journal of the Chemical Society, 1952, p. 2042,2044
[5] Journal of the Chemical Society, 1952, p. 2042,2044

5-Bromo-2-chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride Sodium nitrite Phosphorus pentachloride 2-Amino-5-bromopyridine Nitric acid Sulfuric acid

Preparation Products

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View Lastest Price from 5-Bromo-2-chloro-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Henan Fengda Chemical Co., Ltd
Product
5-Bromo-2-chloro-3-nitropyridine 67443-38-3
Price
US $6.00-0.20/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03

67443-38-3, 5-Bromo-2-chloro-3-nitropyridineRelated Search:

1-Hexadecylpyridinium bromide Clopidol 2-Chloro-3-nitropyridine 3-Amino-5-bromo-2-chloropyridine 2,3,5,6-Tetrachloropyridine 4-Chloro-3-nitropyridine 4-Nitrophenyl chloroformate 2-Chloro-3-fluoropyridine 3-AMINO-2-CHLORO-5-PICOLINE 2-Chloro-5-fluoronicotinonitrile 2-Chloro-3-pyridinamine 4-Bromo-2-chloro-3-iodopyridine 3-Amino-2-chloro-4-methylpyridine 5-Amino-2-chloro-3-picoline 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 6-Bromo-2-chloro-3-iodopyridine 2-Chloro-3-methyl-5-nitropyridine 2-Chloro-3-methyl-5-bromopyridine

  • RARECHEM AL BO 2390
  • 2-Chloro-3-nitro-5-bromopyridine
  • 2-CHLORO-5-BROMO-3-NITROPYRIDINE
  • 5-BROMO-2-CHLORO-3-NITROPYRIDINE 98%
  • 5-Bromo-2-chloro-3-nitropyridine,98%
  • 5-Bromo-2-chloro-3-nitrop...
  • 5-BroMo-2-chloro-3-nitropyridine, 98% 1GR
  • 5-BroMo-2-chloro-3-nitropyridine, 98% 5GR
  • 2 - chloro - 3 - nitro - 5 - broMide pyridine
  • Pyridine, 5-bromo-2-chloro-3-nitro-
  • 2-chloro -3-nitro -5-pyridyl broMide
  • 2-PYRIDINECARBOXYLIC ACID, 5-BROMO-
  • 5-Bromo-2-ch
  • 5-BROMO-2-CARBOXYPYRIDINE
  • 5-BROMO-2-CHLORO-3-NITROPYRIDINE
  • 5-BROMO-2-PICOLINIC ACID
  • IFLAB-BB F1957-0001
  • 5-Bromo-2-chloro-3-nitropyridine &gt
  • 5-Bromo-2-chloro-3-nitropyridine ISO 9001：2015 REACH
  • 2-Cholor-5-bromo-3-nitro pyridine
  • Medetomidine Impurity 65
  • 67443-38-3
  • 30776-11-1
  • C5H2BrCl2N2O2
  • C5H2BrClN2O2
  • Heterocyclic Compounds
  • Boronic Acid
  • Pyridine Series
  • blocks
  • Bromides
  • Pyridine
  • pyridines
  • compounds of pyridine
  • Aromatics
  • Heterocycles
  • Miscellaneous Reagents
  • bc0001