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Antiviral drugs

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At present, virus infection is the most prevalent disease in the world, about 60% of the infectious disease is caused by a virus, and new viruses have been found constantly, which is highly contagious and has high fatality rate, causing serious harm to human health. Antiviral therapy is the fundamental treatment of viral infectious diseases. For acute infection, antiviral therapy helps to reduce symptoms and shorten the course of treatment; and for chronic persistent infection is the treatment of the fundamental, such as AIDS, hepatitis B, hepatitis C and so on. Different viral infections cause different disorders and require different antiviral medications.
Although over the years the development of gene engineering and chemical synthesis of antiviral drugs for clinical use of drugs to control the virus infection and provide more choices and opportunities, and it has been confirmed to have clinical value of antiviral drugs is still one of the few, drug indications are very limited.
In particular, it is difficult to achieve a cure for some of the chronic viral infections. Because the virus is obligate intracellular parasites, its proliferation depends on biosynthesis of the host cell, some virus nucleic acid directly integrated into the host cell gene. Therefore, it is necessary to select antiviral drugs according to the characteristics of the virus. Antiviral drugs should selectively destroy or inhibit the virus inside and outside of the cell, while for normal cells, at least for non-infected cells do not produce lethal damage. Therefore, it is more difficult to make antiviral drugs that have an inhibitory effect on the intracellular virus, to achieve clinical antiviral effect, but not on the metabolism of the host cell. In addition, the better effect of antiviral drugs to protect uninfected cells and early infection cell that have not yet produced significant lesions, however, the symptoms of viral infectious diseases are lack of specificity, it is not easy to diagnose early, when the clinical symptoms appear of virus infection, the virus proliferation has reached a certain degree. For example, a large number of viruses have been infected and release in the cell proliferation When the prevalence of influenza and Japanese encephalitis, and the body is in viremia or viremia late stage, has caused tissue damage, then we should check with effective virus drugs, although it is possible to control the further proliferation and spread of the virus, but often "too late", has not played a decisive role in the treatment. Some virus-induced syndromes are common and relatively benign or self-limiting, so that only drugs with a high therapeutic index (ratio of efficacy to toxicity) can be accepted. So it is still very difficult task to develop safe and effective, selective, easy to use antiviral drugs.

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Structure:
Chemical Name:
Lopinavir
CAS:
192725-17-0
MF:
C37H48N4O5
Structure:
Chemical Name:
Maraviroc
CAS:
376348-65-1
MF:
C29H41F2N5O
Structure:
Chemical Name:
2-[(Acetyloxy)methoxy]ethyl acetate
CAS:
59278-00-1
MF:
C7H12O5
Structure:
Chemical Name:
1,3-Diacetoxy-2-(acetoxymethoxy)propane
CAS:
86357-13-3
MF:
C10H16O7
Structure:
Chemical Name:
2,5,6-Triaminopyrimidin-4-ol sulphate
CAS:
1603-02-7
MF:
C4H7N5O4S
Structure:
Chemical Name:
Nevirapine
CAS:
129618-40-2
MF:
C15H14N4O
Structure:
Chemical Name:
Entecavir hydrate
CAS:
209216-23-9
MF:
C12H17N5O4
Structure:
Chemical Name:
Tenofovir disoproxil fumarate
CAS:
202138-50-9
MF:
C23H34N5O14P
Structure:
Chemical Name:
NELFINAVIR
CAS:
159989-64-7
MF:
C32H45N3O4S
Structure:
Chemical Name:
Tenofovir
CAS:
147127-20-6
MF:
C9H14N5O4P
Structure:
Chemical Name:
DELAVIRDINE
CAS:
136817-59-9
MF:
C22H28N6O3S
Structure:
Chemical Name:
Abacavir sulfate
CAS:
188062-50-2
MF:
C28H38N12O6S
Structure:
Chemical Name:
Acyclovir
CAS:
59277-89-3
MF:
C8H11N5O3
Structure:
Chemical Name:
Efavirenz
CAS:
154598-52-4
MF:
C14H9ClF3NO2
Structure:
Chemical Name:
Idoxuridine
CAS:
54-42-2
MF:
C9H11IN2O5
Structure:
Chemical Name:
Adefovir dipivoxil
CAS:
142340-99-6
MF:
C20H32N5O8P
Structure:
Chemical Name:
Trifluridine
CAS:
70-00-8
MF:
C10H11F3N2O5
Structure:
Chemical Name:
Emtricitabine
CAS:
143491-57-0
MF:
C8H10FN3O3S
Structure:
Chemical Name:
Cidofovir
CAS:
149394-66-1
MF:
C8H14N3O6P
Structure:
Chemical Name:
Ritonavir
CAS:
155213-67-5
MF:
C37H48N6O5S2
Structure:
Chemical Name:
Famciclovir
CAS:
104227-87-4
MF:
C14H19N5O4
Structure:
Chemical Name:
Baloxavir
CAS:
1985605-59-1
MF:
C24H19F2N3O4S
Structure:
Chemical Name:
Entecavir
CAS:
142217-69-4
MF:
C12H15N5O3
Structure:
Chemical Name:
Dideoxyinosine
CAS:
69655-05-6
MF:
C10H12N4O3
Structure:
Chemical Name:
Ribavirin
CAS:
36791-04-5
MF:
C8H12N4O5
Structure:
Chemical Name:
Tenofovir disoproxil
CAS:
201341-05-1
MF:
C19H30N5O10P
Structure:
Chemical Name:
Rimantadine hydrochloride
CAS:
1501-84-4
MF:
C12H22ClN
Structure:
Chemical Name:
Lamivudine
CAS:
134678-17-4
MF:
C8H11N3O3S
Structure:
Chemical Name:
Tenofovir Alafenamide Fumarate
CAS:
1392275-56-7
MF:
C25H33N6O9P
Structure:
Chemical Name:
Zidovudine
CAS:
30516-87-1
MF:
C10H13N5O5
Structure:
Chemical Name:
OSELTAMIVIR
CAS:
196618-13-0
MF:
C16H28N2O4
Structure:
Chemical Name:
Raltegravir potassium
CAS:
871038-72-1
MF:
C20H20FN6O5.K
Structure:
Chemical Name:
Saquinavir
CAS:
127779-20-8
MF:
C38H50N6O5
Structure:
Chemical Name:
Adefovir
CAS:
106941-25-7
MF:
C8H12N5O4P
Structure:
Chemical Name:
PotassiuM sodiuM Dehydroandrographolide Succinate
CAS:
863319-40-8
MF:
C28H38KNaO10
Structure:
Chemical Name:
2'-Deoxy-L-thymidine
CAS:
3424-98-4
MF:
C10H14N2O5
Structure:
Chemical Name:
Atovaquone
CAS:
95233-18-4
MF:
C22H19ClO3
Structure:
Chemical Name:
Stavudine
CAS:
3056-17-5
MF:
C10H12N2O4
Structure:
Chemical Name:
2'-Deoxycytidine
CAS:
207121-53-7
MF:
C9H15N3O5
Structure:
Chemical Name:
Vidarabine
CAS:
5536-17-4
MF:
C10H13N5O4
Structure:
Chemical Name:
pirodavir
CAS:
124436-59-5
MF:
C21H27N3O3
Structure:
Chemical Name:
Arbidol hydrochloride
CAS:
131707-23-8
MF:
C22H26BrClN2O3S
Structure:
Chemical Name:
Cidofovir
CAS:
113852-37-2
MF:
C8H14N3O6P
Structure:
Chemical Name:
Abacavir
CAS:
136470-78-5
MF:
C14H18N6O
Structure:
Chemical Name:
(R)-(+)-9-(2-Hydroxypropyl)adenine
CAS:
14047-28-0
MF:
C8H11N5O
Structure:
Chemical Name:
Raltegravir
CAS:
518048-05-0
MF:
C20H21FN6O5
Structure:
Chemical Name:
NETOBIMIN
CAS:
88255-01-0
MF:
C14H20N4O7S2
Structure:
Chemical Name:
Ganciclovir
CAS:
82410-32-0
MF:
C9H13N5O4
Structure:
Chemical Name:
Tecovirimat
CAS:
816458-31-8
MF:
C19H15F3N2O3
Structure:
Chemical Name:
Valacyclovir hydrochloride
CAS:
124832-27-5
MF:
C13H21ClN6O4
Structure:
Chemical Name:
Ganciclovir sodium
CAS:
107910-75-8
MF:
C9H12N5NaO4
Structure:
Chemical Name:
PLECONARIL
CAS:
153168-05-9
MF:
C18H18F3N3O3
Structure:
Chemical Name:
Asunaprevir
CAS:
630420-16-5
MF:
C35H46ClN5O9S
Structure:
Chemical Name:
Exalamide
CAS:
53370-90-4
MF:
C13H19NO2
Structure:
Chemical Name:
Clevudine
CAS:
163252-36-6
MF:
C10H13FN2O5
Chemical Name:
INTERFERON ALPHA RECOMBINANT RAT
CAS:
307005-25-0
Chemical Name:
Dicacetyl-Aciclovir
MF:
C12H15N5O5
Structure:
Chemical Name:
Moroxydine hydrochloride
CAS:
3160-91-6
MF:
C6H14ClN5O
Structure:
Chemical Name:
Valaciclovir
CAS:
124832-26-4
MF:
C13H20N6O4
Chemical Name:
RIMANTADINE HCL USP(CRM STANDARD)
Structure:
Chemical Name:
2,4,6-Triiodoresorcinol
CAS:
19403-92-0
MF:
C6H3I3O2
Structure:
Chemical Name:
Moroxydine
CAS:
3731-59-7
MF:
C6H13N5O
Structure:
Chemical Name:
Tilorone
CAS:
27591-97-5
MF:
C25H34N2O3
Structure:
Chemical Name:
ABACAVIR SULFATE
CAS:
136777-48-5
MF:
C28H38N12O6S
Structure:
Chemical Name:
Aciclovir sodium
CAS:
69657-51-8
MF:
C8H12N5NaO3
Structure:
Chemical Name:
Foscarnet sodium
CAS:
63585-09-1
MF:
CNa3O5P
Structure:
Chemical Name:
Indinavir
CAS:
150378-17-9
MF:
C36H47N5O4
Structure:
Chemical Name:
Brivudine
CAS:
69304-47-8
MF:
C11H13BrN2O5
Structure:
Chemical Name:
Tilorone dihydrochloride
CAS:
27591-69-1
MF:
C25H36Cl2N2O3
Structure:
Chemical Name:
Arbidol
CAS:
131707-25-0
MF:
C22H25BrN2O3S
Structure:
Chemical Name:
FTIBAMZONE
CAS:
210165-00-7
MF:
C14H15N7O2S2
Structure:
Chemical Name:
Penciclovir
CAS:
39809-25-1
MF:
C10H15N5O3
Structure:
Chemical Name:
Peramivir
CAS:
229614-55-5
MF:
C15H28N4O4
Structure:
Chemical Name:
3-NITROSOBENZAMIDE
CAS:
144189-66-2
MF:
C7H6N2O2
Structure:
Chemical Name:
Indinavir sulfate
CAS:
157810-81-6
MF:
C36H49N5O8S